A kind of edoxaban tosylate tablet and preparation method thereof
A technology of edoxaban tosylate and tablet, applied in the field of medicine, can solve the problems of unfavorable clinical treatment, reduced bioavailability, poor dissolution and the like
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Embodiment 1
[0039] Embodiment 1, preparation edoxaban tosylate sheet
[0040] The present embodiment provides the prescription and preparation method for preparing 1000 Edoxaban Tosylate Tablets (the specification is 15 mg / tablet, calculated as Edoxaban), as follows:
[0041] Prescription composition:
[0042]
[0043]
[0044] Crushing the raw material edoxaban toluenesulfonate (D90≤25 μm) through a 100-mesh sieve, mannitol and pregelatinized starch as auxiliary materials, respectively, through a 80-mesh sieve, and magnesium stearate through a 100-mesh sieve;
[0045] The preparation method is as follows:
[0046] 1) Weigh the prescription amount of edoxaban tosylate, hydrophilic polymer carrier (HPMCAS, PVP-K30), surfactant (poloxamer 188) and dissolve in 2.5L solvent (dimethyl sulfoxide In the mixed solvent that is 1:4 with water volume ratio), adopt ultrasonic-assisted dissolving to obtain homogeneous solution; Then remove described solvent with spray drying, obtain edoxaban tos...
Embodiment 2
[0049] Embodiment 2, preparation Edoxaban tosylate sheet
[0050] The present embodiment provides the prescription and preparation method for preparing 1000 Edoxaban Tosylate Tablets (the specification is 30 mg / tablet, calculated as Edoxaban), as follows:
[0051] Prescription composition:
[0052]
[0053]
[0054] The preparation method is basically the same as in Example 1.
Embodiment 3
[0055] Embodiment 3, preparation Edoxaban tosylate sheet
[0056] The present embodiment provides the prescription and preparation method for preparing 1000 Edoxaban Tosylate Tablets (the specification is 15 mg / tablet, calculated as Edoxaban), as follows:
[0057] Prescription composition:
[0058]
[0059] The preparation method is basically the same as in Example 1.
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