5results about How to "Improve dissolution behavior" patented technology

The present invention relates to a eucommia tea and a preparation method thereof, and relates to the technical field of eucommia tea. The preparation method comprises the following steps: pulverizing and screening eucommia leaves to obtain eucommia leaf powder; subjecting the eucommia leaf powder to low-temperature plasma treatment to obtain pretreated eucommia leaf powder; adding the pretreated eucommia leaf powder to water for vacuum distillation extraction to obtain an extract; concentrating and drying the extract to obtain the eucommia tea. The present invention improves the dissolution behavior of eucommia leaves by subjecting the eucommia leaves to low-temperature plasma pretreatment, which is beneficial to the dissolution rate of effective components in the extraction process; and at the same time, combined with the vacuum distillation extraction technology under appropriate parameters, the damage of high temperature to the active components is reduced, which not only significantly increases the content of the target active components in the obtained eucommia tea, but also improves its appearance, color and taste, making up for the shortcomings of the existing eucommia tea.

The invention discloses a tigorazan amorphous solid dispersion, a tigorazan-containing tablet core, a tigorazan tablet and a preparation process of the tigorazan amorphous solid dispersion. The invention specifically discloses a tigorasan solid dispersion. The tigorasan solid dispersion comprises tigorasan and a carrier, the tigorasan is one or more of a tigorasan A crystal form, a tigorasan B crystal form and a tigorasan amorphous form; the carrier comprises copovidone and polyethylene glycol; the mass ratio of the copovidone to the polyethylene glycol is 1: (0.5-2). The invention also provides a preparation method of the tigorazan solid dispersion, a tigorazan-containing tablet core and a preparation method thereof, and a tigorazan tablet and a preparation method thereof. According to the method disclosed by the invention, wet granulation is adopted, so that the preparation process is simpler, the product quality is easier to control, the production efficiency is improved, large-scale production is facilitated, and the prepared tigoraz tablets are good in content uniformity and good in stability.

The invention provides a vitamin U belladonna aluminum capsule, which is characterized in that a belladonna extract is adsorbed in pores of a mixture of a mannitol cross-polymerized barley-mountain co-treated material phemaburst # imgabs 0 # mesoporous silica # imgabs 1 #, and the mixture provides a weak acid environment for the belladonna extract. The weak acid environment can improve the stability of atropine; meanwhile, the rapid desorption of the belladonna extract can be met, so that the capsule is rapidly disintegrated; in addition, migrated moisture in a gelatin capsule shell can be locked preferentially, the stability of the vitamin UII is improved, and an acceleration test proves that the product obtained by the invention can have better dissolution behavior and stability and is obviously superior to that of an existing preparation.

The invention relates to a preparation method of low-solvent small-particle-size tadalafil, and belongs to the technical field of medicine crystallization. The method comprises the following steps: adding a tadalafil crude product into a mixed solvent of acetonitrile and water, heating, dissolving, filtering, dropwise adding filtrate into water, carrying out heat preservation, pulping, carrying out suction filtration, drying, and collecting to obtain a small-particle-size sample. The particle size of the tadalafil obtained by the method is controlled to be less than 10 microns, the dissolution behavior of an indissolvable drug solid preparation is improved, and the dissolution rate and dissolution rate of the drug are improved.

The invention provides an orally disintegrating tablet containing finasteride and tadalafil and a preparation method thereof. The orally disintegrating tablet comprises the following raw materials in percentage by weight: 3%-5% of finasteride, 3%-5% of tadalafil, 78%-85% of mannitol, 2%-5% of croscarmellose sodium, 3%-5% of povidone, 1%-5% of sucralose, 1%-3% of aspartame, 1%-2% of apple powder essence and 1%-3% of colloidal silicon dioxide. 1%-3% of magnesium stearate; according to the orally disintegrating tablet, the defects of capsule preparations in the prior art are overcome, the medication compliance of old men and patients with swallowing difficulty is greatly improved by taking the orally disintegrating tablet, and the orally disintegrating tablet provided by the invention is good in dissolution behavior, quick to disintegrate in the oral cavity, good in taste, obvious in taste modifying effect and free of gravel taste.