Pharmaceutical preparation containing cyclin inhibitor, and preparation method thereof
A drug and composition technology, applied in the field of pharmaceutical preparations and preparations of cyclin inhibitors, can solve the problems of high incidence and slow progress of the disease, and achieve the effects of excellent dissolution behavior and good bioavailability in vivo
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Embodiment 1
[0045] 1.1 Unit prescription composition
[0046]
[0047]
[0048] Note: " / " means not added.
[0049] 1.2 Preparation
[0050] Put the above-mentioned 1,000 tablets of the formula I compound and other excipients except magnesium stearate into the hopper mixer and mix evenly, add a wetting agent to moisten the granules, dry on a fluidized bed at 45°C for 10 minutes, and sieve the granules with a size of 1.0 mm. Add magnesium stearate and mix for 10 minutes, control the content in the middle, and fill the capsules. Or compressed into tablets.
[0051] 1.3 Dissolution data
[0052]
Embodiment 2
[0054] 2.1 Composition of unit prescription
[0055]
Prescription 9
Prescription 10
Prescription 11
Prescription 12
Formula I compound
75
75
100
125
microcrystalline cellulose
38.7
10.8
93.9
117.3
lactose
54.3
18.8
49.7
65.7
Hypromellose
/
/
/
17.5
Povidone
10.5
3.5
14
/
Carboxymethyl Starch Sodium
/
10.5
14
17.5
Croscarmellose Sodium
21
/
/
/
Sodium dodecyl sulfate
2.1
/
2.8
/
Talc powder
2.1
0.7
2.8
3.5
[0056] Magnesium stearate
2.1
0.7
2.8
3.5
weight
210
120
280
350
[0057] Note: " / " means not added.
[0058] 2.2 Preparation
[0059] Put the above 1000 tablets of formula Ⅰ compound and other excipients except magnesium stearate into the hopper mixer for mixing, use a roller p...
Embodiment 3
[0063] 3.1 Unit prescription composition
[0064]
Prescription 13
Prescription 14
Prescription 15
Formula I compound
75
75
75
microcrystalline cellulose
71.8
/
50
lactose
35.9
25.8
15.7
Hypromellose
10.5
6.0
9.0
Carboxymethyl Starch Sodium
10.5
6.0
5.0
Crospovidone
/
3.0
4.0
Sodium dodecyl sulfate
2.1
/
2.1
Talc powder
2.1
2.1
2.1
Magnesium stearate
2.1
2.1
2.1
weight
210
120
165
[0065] Note: " / " means not added.
[0066] 3.2 Preparation
[0067] Put the above 1000 tablets of the formula I compound and excipients into the hopper mixer and mix evenly, control the content in the middle, and fill the capsules. Or compressed into tablets.
[0068] 3.3 Dissolution data
[0069]
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