Solid preparation of clopidogrel or pharmaceutically acceptable salt thereof

A technology of solid preparations and clopidogrel, applied in medical preparations with non-active ingredients, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve problems such as unclear products, shorten exposure time and ensure quality , to avoid the effect of water degradation

Active Publication Date: 2010-12-29
CHINA RESOURCES SAIKE PHARMA
View PDF2 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clopidogrel has no biological activity in vitro, and needs to be transformed by hepatic cytochrome P450 e

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0026] Example 1:

[0027] Clopidogrel Bisulfate Tablets (25mg Specification)

[0028] Component

[0029] Silica

[0030] Preparation method:

[0031] 1. Mix clopidogrel bisulfate with silica evenly;

[0032] 2. Add lactose, part of pregelatinized starch, and hydroxypropyl methylcellulose to 1 and mix well;

[0033] 3. Add talcum powder to 2 and mix well; then press tablets.

Example Embodiment

[0034] Example 2:

[0035] Clopidogrel Bisulfate Tablets (75mg Specification)

[0036] Component

[0037] Preparation method:

[0038] 1. Mix clopidogrel bisulfate with silica evenly;

[0039] 2. Add lactose, part of pregelatinized starch, and hydroxypropyl methylcellulose to 1 and mix well;

[0040] 3. Add talcum powder to 2 and mix well; then press tablets.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a solid preparation of clopidogrel or a pharmaceutically acceptable salt thereof, and the adopted technical scheme is as follows: taking the clopidogrel or the pharmaceutically acceptable salt as a principal agent, taking lactose, partially pregelatinized starch, hydroxypropyl methyl cellulose, silicon dioxide and talcum powder as excipients, and directly pressing powder into tablets.

Description

technical field [0001] The invention relates to a solid preparation of an anticoagulant drug clopidogrel or a pharmaceutically active salt thereof and a preparation method thereof. technical background [0002] Clopidogrel is a novel thienopyridine antiplatelet drug with a chemical structure similar to ticlopidine except that there is one more carboxymethyl group on the side chain. Clopidogrel is metabolized in vivo, and its active metabolites can selectively and irreversibly bind to a purine adenosine diphosphate (ADP) receptor on the surface of the platelet membrane, blocking the inhibitory effect of ADP on adenylate cyclase , thereby promoting the phosphorylation of cAMP-dependent, PGE1-stimulated vasodilator-stimulated phosphoprotein (VASP), inhibiting the activation of fibrinogen receptor (GPIIb / IIIa) and inhibiting platelet aggregation. In addition, clopidogrel can reduce the expression of platelet selectin (P-selectin, CD62, a marker of platelet degranulation), and i...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/00A61K31/4365A61K47/38A61P7/02
Inventor 沈泽蒋玲敏
Owner CHINA RESOURCES SAIKE PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products