Tasteless tilmicosin particle and preparation method thereof

A technology of tilmicosin and granules, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve problems affecting palatability, vomiting, animal stimulation, etc., and achieve increased packaging Yield, the effect of prolonging the action time

Inactive Publication Date: 2016-12-07
TIANJIN ZHONGSHENG TIAOZHAN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, it is mainly used to treat infectious diseases caused by sensitive bacteria in cattle, goats, sheep, dairy cows, pigs, chickens and other animals. However, because tilmicosin is very bitter and smelly, it will Affect palatability, on the other hand, it stimulates the stomach of animals, causing vomiting in severe cases, and even some animals refuse to eat when they smell the smell of tilmicosin, which seriously affects the popularization and application of tilmicosin
However, most domestic tilmicosin enteric-coated granules are directly mixed with excipients, which cannot cover up the bitter taste of tilmicosin and affect its therapeutic effect.
CN102319181 discloses a coating process of granular animal medicines, through weighing materials, making soft materials, extruding and spheronizing granulation, fluidized bed drying, coating, polishing, fluidized bed drying, screening, product testing, etc. Steps to prepare granule-type animal drugs, the process is complicated and the cost is high, and the prepared granules are single-layer coating, and its auxiliary material microcrystalline cellulose acts as a filler or binder, and the coating is easy to bite when the animal eats and eats. The bitterness of the main ingredient tilmicosin affects the palatability

Method used

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  • Tasteless tilmicosin particle and preparation method thereof
  • Tasteless tilmicosin particle and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A tilmicosin granule, every 100 granules contains 20 parts of tilmicosin, 30 parts of glyceryl stearate, 37 parts of magnesium stearate, 5 parts of sodium carboxymethyl starch, 6 parts of acrylic resin, twelve 2 parts sodium alkyl sulfate.

[0024] The preparation method of this tilmicosin particle, comprises the steps:

[0025] First weigh 20 parts of tilmicosin, add it into 30 parts of glyceryl stearate in a molten state at 80°C, and stir evenly. Add 37 parts of magnesium stearate and 5 parts of sodium carboxymethyl starch to the above mixture for granulation and spheronization. During the spheronization process, spray the second layer of enteric coating agent on the surface of the granules——6 parts of acrylic resin and A mixed solution of 2 parts of sodium lauryl sulfate is used to obtain approximately spherical particles with a particle diameter of 20-40 meshes, and then dried to obtain the final tilmicosin granule product.

Embodiment 2

[0027] A tilmicosin granule, every 100 granules contains 5 parts of tilmicosin, 5 parts of cetyl alcohol, 5 parts of stearyl alcohol, 65 parts of magnesium stearate, 10 parts of sodium carboxymethyl starch, 7 parts of acrylic resin Parts, 3 parts of sodium lauryl sulfate.

[0028] The preparation method of this tilmicosin particle, comprises the steps:

[0029] First weigh 5 parts of tilmicosin, add it into 5 parts of cetyl alcohol and 5 parts of stearyl alcohol in molten state at 65°C, and stir evenly. Add 65 parts of magnesium stearate and 10 parts of sodium carboxymethyl starch to the above mixture for granulation and spheronization. During the spheronization process, spray the second layer of enteric coating agent on the surface of the granules——7 parts of acrylic resin and 3 parts of sodium lauryl sulfate mixed solution to obtain approximately spherical particles with a particle diameter of 20 to 40 mesh, and then dry to obtain the final tilmicosin granule product.

Embodiment 3

[0031] A kind of tilmicosin granule, every 100 granules contains 10 parts of tilmicosin, 25 parts of glyceryl stearate, 49 parts of magnesium stearate, 8 parts of sodium carboxymethyl starch, 6 parts of acrylic resin, twelve 2 parts sodium alkyl sulfate.

[0032] The preparation method of this tilmicosin particle, comprises the steps:

[0033] First weigh 10 parts of tilmicosin, add it into 25 parts of glyceryl stearate in a molten state at 80°C, and stir evenly. Add 49 parts of magnesium stearate and 8 parts of sodium carboxymethyl starch to the above mixture for granulation and spheronization. During the spheronization process, spray the second layer of enteric coating agent on the surface of the granules——6 parts of acrylic resin and A mixed solution of 2 parts of sodium lauryl sulfate is used to obtain approximately spherical particles with a particle diameter of 20-40 meshes, and then dried to obtain the final tilmicosin granule product.

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Abstract

The invention relates to an odorless tilmicosin granule and a preparation method thereof. The tilmicosin granule is prepared from tilmicosin, an inner layer coating material, a granulation auxiliary material and an outer layer coating material, wherein every 100 Each granule contains 5-25 parts of tilmicosin, 8-40 parts of inner layer coating material, 20-80 parts of granulation auxiliary material, and 2-10 parts of outer layer coating material; The inner layer coating material is one or more combinations of glyceryl stearate, cetyl alcohol, and stearyl alcohol, and the granulation auxiliary material is a combination of magnesium stearate and sodium carboxymethyl starch. One or two combinations, the outer coating material is a combination of acrylic resin and sodium lauryl sulfate. The present invention performs secondary packaging on the tilmicosin to isolate the tilmicosin from the external environment, which not only covers up the bitter taste of the tilmicosin, but also does not affect the palatability of the feed.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine and relates to a tilmicosin preparation, in particular to an odorless tilmicosin granule and a preparation method thereof. Background technique [0002] Tilmicosin is a derivative of tylosin after acid hydrolysis. It is a semi-synthetic macrolide antibiotic for animals. Its molecular formula is C46H80N2O13 and its molecular weight is 869.15. Antibacterial activity, effective against Gram-positive bacteria and some Gram-negative bacteria and mycoplasma. Especially for Actinobacillus pleuropneumoniae, Pasteurella, Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Corynebacterium pyogenes and mycoplasma of livestock and poultry, the activity is stronger than tylosin. Clinically, it is mainly used to treat infectious diseases caused by sensitive bacteria in cattle, goats, sheep, dairy cows, pigs, chickens and other animals. However, because tilmicosin is very bitter...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K31/706A61K47/20A61P31/04
Inventor 王猛张娜王建程雪娇余贵菊张立会朱士江姜淋洁崔志刚焦晓军王勇甄盼盼李丽琴于小婷杨雪王宇鹏杜宁宁范庆增李玲
Owner TIANJIN ZHONGSHENG TIAOZHAN BIOTECH
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