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Application of hydrogen sulfide in preparing medicines for treating inflammatory anemia

A hydrogen sulfide, inflammatory technology, used in drug combinations, antipyretics, anti-inflammatory agents, etc., can solve problems that have not yet been seen

Inactive Publication Date: 2016-12-07
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, there is no research report on whether hydrogen sulfide is related to iron metabolism and the effect of hydrogen sulfide on inflammatory anemia

Method used

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  • Application of hydrogen sulfide in preparing medicines for treating inflammatory anemia
  • Application of hydrogen sulfide in preparing medicines for treating inflammatory anemia
  • Application of hydrogen sulfide in preparing medicines for treating inflammatory anemia

Examples

Experimental program
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Effect test

Embodiment 1

[0025] Materials and methods:

[0026] 1. Animals C57B6 male mice, 8 weeks old, were randomly divided into four groups according to body weight after adaptive feeding for one week, respectively blank control group (CON), sodium hydrosulfide group (NaSH), lipopolysaccharide group (LPS), Lipopolysaccharide and sodium hydrosulfide group (LPS+NaSH), 5 rats in each group. Mice were administered at 100μl / 10g, intraperitoneally injected, the blank control group was given PBS, the sodium hydrogen sulfide group was given 5 mg / kg Body Weight sodium hydrogen sulfide, and the lipopolysaccharide group was given 1 mg / kg Body Weight lipopolysaccharide, lipopolysaccharide and sodium hydrogen sulfide The group was given 5mg / kg Body Weight sodium hydrosulfide and 1mg / kg Body Weight lipopolysaccharide at the same time. After 6 hours and 24 hours of administration, the eyeballs were removed to take blood, and the spleen was routinely dissected;

[0027] 2. Preparation of serum:

[0028]The blo...

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Abstract

The invention belongs to the fields of medicines and pharmacology, and relates to a novel pharmaceutical application of hydrogen sulfide in pharmacology, in particular to an application of the hydrogen sulfide in preparing medicines for treating inflammatory anemia. By conducting experiments on the influence of the hydrogen sulfide on the serum iron of normal mice and mice with the inflammatory anemia, experimental results indicate that the hydrogen sulfide, under a physiological condition, can significantly improve the serum iron and iron-carrying saturation of the mice by increasing TFR (transferrin receptor) protein expression; for a model of the mice with the inflammatory anemia, the hydrogen sulfide, by inhibiting the decrease of TFR and EPN proteins caused by lipopolysaccharide, can significantly inhibit the decline of the serum iron and iron-carrying saturation caused by the lipopolysaccharide; and for peritoneal induced primary macrophage, the hydrogen sulfide, under the physiological condition, can significantly increase the TFR protein expression, and for a lipopolysaccharide-processed cell mode, the hydrogen sulfide can inhibit lipopolysaccharide-induced TFR decrease. The experimental results prove that the hydrogen sulfide can be used for preparing the medicines for treating the inflammatory anemia.

Description

technical field [0001] The invention belongs to the field of medicine and pharmacy, and relates to the new medicine use of hydrogen sulfide in medicine, in particular to the use of hydrogen sulfide in preparing medicine for treating inflammatory anemia. Background technique [0002] The prior art discloses that iron is an indispensable and essential trace element for all living organisms, and is also the most abundant transition metal element in the human body; studies have shown that iron homeostasis must rely on the absorption, uptake, utilization, and storage of iron ions. Coordination, any problem in any link will lead to changes in iron content; too high or too low iron content will affect the biological activity of the body; for example, iron deficiency will cause body metabolic disorders with anemia as the main clinical symptom; Iron-deficiency anemia is the most common nutrient deficiency disease worldwide, especially in developing countries; statistics show that the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/04A61P7/06A61P29/00
Inventor 钱忠明周玉付柯亚陈萍
Owner FUDAN UNIV
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