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Extraction method of siraitia grosvenorii fruits and siraitia grosvenorii fruit composition

An extraction method, the technology of Luo Han Guo, applied in the direction of drug combination, separation method, chemical instrument and method, etc., can solve the problems of low content of active ingredients, large dosage for patients, inconvenient taking, etc., and achieve stable active ingredients, strong applicability, Solve the effect of low drying efficiency

Inactive Publication Date: 2016-12-07
NANJING ZHENGKUAN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The extraction method of Luo Han Guo in the prior art has rough and backward technology, many impurities, and low content of active ingredients, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects the clinical application of this product

Method used

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  • Extraction method of siraitia grosvenorii fruits and siraitia grosvenorii fruit composition
  • Extraction method of siraitia grosvenorii fruits and siraitia grosvenorii fruit composition
  • Extraction method of siraitia grosvenorii fruits and siraitia grosvenorii fruit composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Take 1000g of Luo Han Guo, wash it quickly, cut it into sections, dry it in the sun, take it out, add 10 times the weight of water, soak it for 0.5h, decoct it for 1 hour, filter it, add the dregs of the medicine, add water 8 times the weight of the medicinal material, and decoct it for 1 hour, Filter out the medicinal liquid, combine two decoction liquids, concentrate to 60°C with a relative density of 1.05, add ethanol so that the volume percentage of alcohol content reaches 75%, stir, stand still, filter, and when the filtrate is concentrated to 65°C, the relative density is 1.25, and recover ethanol to obtain a concentrated solution, which is refined with silica gel to obtain an effluent, which is further concentrated, dried and granulated to obtain Luo Han Guo granules.

[0022] The extraction method of Luo Han Guo, the silica gel refining method is as follows: pre-load the selected silica gel into a resin column, and at the same time dilute the concentrated solutio...

Embodiment 2

[0034] Take 1000g of Luo Han Guo, wash it quickly, cut it into sections, dry it in the sun, take it out, add 10 times the weight of water, soak it for 0.5h, decoct it for 1 hour, filter it, add the dregs of the medicine, add water 8 times the weight of the medicinal material, and decoct it for 1 hour, Filter out the medicinal liquid, combine two decoction liquids, concentrate to 60°C with a relative density of 1.05, add ethanol so that the volume percentage of alcohol content reaches 75%, stir, stand still, filter, and when the filtrate is concentrated to 65°C, the relative density is 1.25, and recover ethanol to obtain a concentrated solution, which is refined with silica gel to obtain an effluent, which is further concentrated, dried and granulated to obtain Luo Han Guo granules.

[0035] The extraction method of Luo Han Guo, the silica gel refining method is as follows: pre-load the selected silica gel into a resin column, and at the same time dilute the concentrated solutio...

Embodiment 3

[0040] Take 1000g of Luo Han Guo, wash it quickly, cut it into sections, dry it in the sun, take it out, add 10 times the weight of water, soak it for 0.5h, decoct it for 1 hour, filter it, add the dregs of the medicine, add water 8 times the weight of the medicinal material, and decoct it for 1 hour, Filter out the medicinal liquid, combine two decoction liquids, concentrate to 60°C with a relative density of 1.05, add ethanol so that the volume percentage of alcohol content reaches 75%, stir, stand still, filter, and when the filtrate is concentrated to 65°C, the relative density is 1.25, and recover ethanol to obtain a concentrated solution, which is refined with silica gel to obtain an effluent, which is further concentrated, dried and granulated to obtain Luo Han Guo granules.

[0041] The extraction method of Luo Han Guo, the silica gel refining method is as follows: pre-load the selected silica gel into a resin column, and at the same time dilute the concentrated solutio...

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Abstract

The invention provides a processing extraction method of siraitia grosvenorii fruits. The extraction method comprises the steps that the siraitia grosvenorii fruits are quickly washed, cut into segments, dried, taken out, soaked for 0.5 h by adding water of which the weight is 10 times the siraitia grosvenorii fruits, decocted for 1 h and then filtered; the medicine dregs are decocted for 1 h by adding water of which the weight is 8 times the medicinal materials, and medicinal liquid is filtered; first-time decoction liquid and second-time decoction liquid are mixed, and the mixed liquid is concentrated until the relative density is 1.05 at 60 DEG C; ethyl alcohol is added into the concentrated liquid to enable the volume percent of the alcohol content to reach 75%, stirring, standing and filtering are conducted, the filtrate is concentrated until the relative density is 1.25 at 65 DEG C, ethyl alcohol is recycled, and concentrated liquid is obtained; refining is conducted through silica gel, the selected silica gel is contained in resin columns in advance, impurities in the concentrated liquid are removed through reverse phase silica gel columns after the concentrated liquid is diluted by purified water, and all effluent is collected; the effluent continues to be concentrated, the concentrated liquid is dried and granulated to obtain siraitia grosvenorii fruit granules, and high-content mogroside V is prepared and is compatible with arctiin and catechin to prepare the siraitia grosvenorii fruit composition.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine extraction, in particular to an extraction method of Luo Han Guo and a composition of Luo Han Guo. Background technique [0002] The extracting method of Luo Han Guo in the prior art has a rough and backward process, many impurities, and low content of active ingredients, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects the clinical application of this product. Contents of the invention [0003] Purpose of the invention: In order to solve the above problems, the purpose of the present invention is to provide a method for extracting Luo Han Guo and a composition of Luo Han Guo. [0004] Technical scheme: the purpose of the present invention is achieved by the following scheme: [0005] A method for extracting Luo Han Guo, the preparation method is: take Luo Han Guo, wash quickly, cut into sections, dry in the sun, take it out,...

Claims

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Application Information

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IPC IPC(8): A61K36/42A61P31/04A61P35/00B01D1/14A61K31/7048A61K31/353
CPCA61K9/1605A61K31/353A61K31/7048A61K36/42A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2236/55B01D1/0017B01D1/14A61K2300/00
Inventor 卞毓平
Owner NANJING ZHENGKUAN MEDICAL TECH
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