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Lotus leaf composition and application thereof

A technology of composition and lotus leaf, which is applied in application, drug combination, food science, etc., can solve problems such as increased liver fat content, weight gain, Mt insufficiency, etc., and achieve good social benefits, good safety, and high utilization Effect

Inactive Publication Date: 2016-12-14
杭州沃亚生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, due to more and more reports of serious adverse reactions of weight-loss drugs, in 2011, the United States, the European Union, and the China Food and Drug Administration successively announced the prohibition of the continued application of these weight-loss drugs in clinical practice. At present, there are no safe and effective weight-loss drugs in the world Available for prescription; although many lipid-lowering drugs such as statins and fibrates have obvious hypolipidemic effect, they increase liver fat content, promote lipid peroxidation, and aggravate hepatic fat deposition; insulin sensitizers (such as thiazolidine Diketones (TzDs) have the effect of AMPK agonist and the effect of reducing FFA and inflammatory cytokines, but can induce adverse reactions such as weight gain and Mt dysfunction; antioxidants such as Vit E, phosphatidylcholine, silymarin, etc. The expression of genes related to liver structure and function plays a certain role in anti-necrosis, apoptosis, anti-inflammation, anti-fibrosis and promotion of liver regeneration, but due to the lack of rationally designed randomized double-blind and placebo-controlled Experimental, it is difficult to assess their respective clinical application status

Method used

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  • Lotus leaf composition and application thereof
  • Lotus leaf composition and application thereof
  • Lotus leaf composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1: Research on the effect of lotus leaf composition on non-alcoholic fatty liver caused by high-fat feed

[0025] 1. Experimental materials

[0026] 1.1. Animals: Male SD rats, weighing 200±20g, provided by the Experimental Animal Center of Zhejiang Academy of Medical Sciences, certificate of conformity: 0012051, license number SCXK (Zhejiang) 2014-0001. They were raised at a room temperature of 23±2°C and a relative humidity of 50% to 70%, with free access to food and water.

[0027] 1.2, the test object: take the right amount of lotus leaf and mulberry leaf powder which have been freeze-dried and crushed through a 800-1000 mesh sieve, and add pure water respectively to form a suspension to obtain the lotus leaf test object and the mulberry leaf test object; Take lotus leaf, sweet potato leaf, lotus leaf and mulberry leaf respectively in the ratio of 8:2, mix, add pure water to configure a suspension, and obtain lotus leaf test substance and lotus mulberry tes...

Embodiment 2

[0048] Example 2: Research on the effect of lotus leaf composition on hyperlipidemia caused by high-fat feed

[0049] 1. Experimental materials

[0050] 1.1. Animals Male SD rats, weighing 200±20g, were purchased from the Experimental Animal Center of Zhejiang Academy of Medical Sciences (animal quality certificate number: 0008677, license number: SCXK (Zhejiang) 2008-0033). They were raised at a room temperature of 23±2°C and a relative humidity of 50%-70%, with free access to food and water.

[0051] 1.2, the test object: take the right amount of lotus leaf and mulberry leaf powder which have been freeze-dried and crushed through a 800-1000 mesh sieve, and add pure water respectively to form a suspension to obtain the lotus leaf test object and the mulberry leaf test object; Take lotus leaf, sweet potato leaf, lotus leaf and mulberry leaf respectively in the ratio of 8:2, mix, add pure water to configure a suspension, and obtain lotus leaf test substance and lotus mulberry ...

Embodiment 3

[0068] Example 3: Effects of Different Compositions on Hepatic Steatosis and Insulin Resistance in Experimental Nonalcoholic Fatty Liver

[0069] In the present invention, lotus leaves, mulberry leaves, tea leaves, sweet potato leaves and other medicinal and edible Chinese herbal medicines / common foods are combined, and the effects of each composition on the liver function and liver index of non-alcoholic fatty liver model rats induced by high sugar and high fat are observed. , hepatic steatosis and insulin-related indicators. The results in Table 3-1 show that the lotus leaf composition group (lotus leaf: mulberry leaf: sweet potato leaf 8:1:1) has a good preventive effect on non-alcoholic fatty liver in the laboratory. The resistance effect is superior to other compositions. Table 3-1: Effects of different compositions on liver function indicators, hepatic steatosis and insulin resistance related indicators in experimental nonalcoholic fatty liver rats

[0070]

[007...

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PUM

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Abstract

The invention discloses a lotus leaf composition and application thereof. The lotus leaf composition is prepared by mixing lotus leaf powder, mulberry leaf powder and sweet potato leaf powder according to the mass ratio of (8-1):(1-8):(1-8), has the effects of regulating blood lipid and blood glucose and preventing and treating the fatty liver and can be used for preparing food, healthcare food and medicine for regulating blood lipid and preventing, relieving and treating the non-alcoholic fatty liver disease. The lotus leaf composition is from medicinal and edible traditional Chinese medicinal materials and food, is suitable for being eaten for a long time, and will bring good social benefits.

Description

technical field [0001] The invention relates to the technical field of raw food, in particular to a lotus leaf composition containing lotus leaf powder, mulberry leaf powder and sweet potato leaf powder and its preparation for preventing, improving and treating hyperlipidemia and non-alcoholic The application of the fatty liver in food, health food or medicine. Background technique [0002] Under normal circumstances, the adipose tissue contained in the human liver accounts for about 2%-4% of the wet weight of the liver. For various reasons, the fat accumulation in the liver exceeds 5%, or it is found that more than 1 / 3 of the unit liver cells have fat droplets in the liver biopsy. Known as fatty liver. Non-alcoholic fatty liver disease (NAFLD) refers to a clinicopathological syndrome characterized by diffuse bullous steatosis in liver cells caused by alcohol and other definite liver damage factors. It accounts for 80% of fatty liver. The disease includes a series of dise...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/00A23P10/40A61K36/62A61P3/06A61P1/16
CPCA61K36/62A23V2002/00A61K36/39A61K36/605A61K2300/00A23V2200/30A23V2200/3262A23V2200/334
Inventor 查森俊
Owner 杭州沃亚生物科技有限公司
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