A kind of modified montmorillonite stable curcumin-loaded Pickering emulsion and preparation method thereof
A curcumin-loaded Pickering emulsion and curcumin-loaded technology are applied in the direction of non-central analgesics, non-active ingredient medical preparations, anti-toxins, etc., to achieve the effects of avoiding toxic side effects and excellent drug slow-release performance
Inactive Publication Date: 2019-07-16
CHONGQING MEDICAL UNIVERSITY
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[0008] After inquiring about patents and literature, there is no relevant report on the use of modified montmorillonite as a stabilizer for curcumin-loaded Pickering emulsion
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[0026] 1. Preparation of modified montmorillonite
[0027] (1) Preparation of blank modified montmorillonite
[0028] Take 1 g of montmorillonite K-10, add 10 mL of concentrated sulfuric acid according to the ratio of solid to liquid ratio 1:10, acidify in a water bath for 0.5 h at a temperature of 70 ° C, then wash the acid with double distilled water until the pH value is neutral, and bake Acidified montmorillonite is obtained after drying. Weigh 50 mg of the eluted acidified montmorillonite, add 4 mL of absolute ethanol, 0.2 mL of 3-aminopropyltriethoxysilane, and stir in the dark for 24 hours, then wash away the uncoupled acidified montmorillonite 3- Aminopropyltriethoxysilane. After drying at 115°C, the modified montmorillonite was obtained with an average particle size of 354nm.
[0029] (2) Preparation of modified montmorillonite loaded with curcumin
[0030] Weigh 6 mg of curcumin crude drug, dissolve it in 12 mL of absolute ethanol, and ultrasonically dissolve the...
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Abstract
The invention discloses a modified-montmorillonite-stabilized curcumin-carrying pickering emulsion and a preparing method thereof. The modified-montmorillonite-stabilized curcumin-carrying pickering emulsion is prepared from, by weight, 0.05% to 0.5% of curcumin bulk drugs, 0.1% to 5% of a stabilizer, 5% to 10% of oil phase matter and the balance water, wherein the total mass of the ingredients is 100%, and the stabilizer is curcumin-carrying modified montmorillonite. According to the modified-montmorillonite-stabilized curcumin-carrying pickering emulsion prepared with the preparing method, the emulsion is stabilized through the modified montmorillonite instead of a surfactant, and the toxic and side effects of the surfactant on the human body are avoided. As the drugs are loaded into the stabilizer montmorillonite, the drug loading capacity of the emulsion is increased.
Description
[0001] 【Technical field】 [0002] The invention belongs to the field of pharmaceutical preparations, in particular to a curcumin-loaded Pickering emulsion stabilized by modified montmorillonite and a preparation method thereof [0003] 【Background technique】 [0004] Curcumin is a diketone compound extracted from the rhizomes of turmeric, araceae, calamus, and turmeric. It has the effects of lowering blood fat, anti-tumor, anti-inflammatory, choleretic, and antioxidant. At present, the research on curcumin in the field of pharmacy is relatively extensive. It is known that the preparations prepared from curcumin include liposomes, self-microemulsions, clathrates, solid dispersions and the like. However, the low solubility of curcumin itself still greatly limits the use of curcumin, and improving the oral bioavailability of curcumin is still a key issue. [0005] Pickering emulsion is an emulsion prepared by using solid particles instead of surfactants as emulsifiers. It was fi...
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IPC IPC(8): A61K9/107A61K31/12A61K47/24A61P3/06A61P35/00A61P29/00A61P39/06
CPCA61K9/107A61K31/12A61K47/24
Inventor 张良珂冉娅
Owner CHONGQING MEDICAL UNIVERSITY