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Motion sickness prevention and treatment pharmaceutical composition, preparation method and uses thereof

A composition and motion sickness technology, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problems of disease occurrence, low glutamic acid concentration, etc.

Active Publication Date: 2016-12-21
BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] (3) When the glutamate transporter is expressed or dysfunctional, it causes a large accumulation of glutamate in the synaptic cleft or extracellular glutamate or the concentration of glutamate is lower than the normal level, which can lead to disease occurrence

Method used

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  • Motion sickness prevention and treatment pharmaceutical composition, preparation method and uses thereof
  • Motion sickness prevention and treatment pharmaceutical composition, preparation method and uses thereof
  • Motion sickness prevention and treatment pharmaceutical composition, preparation method and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0141] Raw material composition:

[0142] Gastrodia elata 9g, patchouli 6g, fried Atractylodes macrocephala 7g, dried ginger 3g,

[0143] Su stem 9g, Guizhi 6g, Poria cocos 6g, Jiang Pinellia 7g,

[0144] Paeoniae Alba 6g, Zhuru 6g, Chenpi 6g, Acanthopanax 5g,

[0145] Clove 4g, Coptidis 4g, Gardenia 6g

[0146] Preparation method: Take the raw material according to the proportion, add water and decoct twice, 1.5 hours each time, combine the decoction, filter, concentrate, dry under reduced pressure, use dextrin as the excipient, and mix according to the ratio of drug to auxiliary 3:1 , mixed evenly, made into granules, dried, and obtained granules.

[0147] Specifications: Each bag weighs 30g, equivalent to 45g of API;

[0148] Usage and dosage: Take after mixing with warm water, 1 bag at a time, 2 times a day.

Embodiment 2

[0150] Raw material composition:

[0151] Gastrodia elata 10g, patchouli 5g, fried Atractylodes macrocephala 6g, dried ginger 4g,

[0152] Su stem 10g, Guizhi 5g, Poria cocos 5g, Jiang Pinellia 8g,

[0153] Paeoniae Alba 7g, Zhuru 5g, Chenpi 5g, Acanthopanax 6g,

[0154] Clove 5g, Coptidis 3g, Gardenia 7g

[0155] Preparation method: Take the raw material drug in proportion, ultrasonically extract twice with 70% ethanol, the first time is 1 hour, and the second time is 0.5 hour, the extracts are combined, filtered, concentrated under reduced pressure, the extract uses dextrin as an excipient, Mix according to the drug-assistant ratio of 3:1, mix evenly, make granules, dry, and obtain granules.

Embodiment 3

[0157] Raw material composition:

[0158] Gastrodia elata 8g, patchouli 7g, fried Atractylodes macrocephala 8g, dried ginger 2g,

[0159] Su stem 8g, Guizhi 7g, Poria cocos 7g, Jiang Pinellia 6g,

[0160] Paeoniae Alba 5g, Zhuru 7g, Chenpi 7g, Acanthopanax 4g,

[0161] Clove 3g, Coptidis 5g, Gardenia 5g

[0162] Preparation method: take the raw material according to the proportion, add water and reflux to extract twice, each time for 1.5 hours, combine the decoction, filter, concentrate, add 60% ethanol solution for alcohol precipitation, stand still, filter, concentrate, dry under reduced pressure, and obtain a paste The essence is an excipient, and it is mixed according to the ratio of drug to auxiliary agent 3:1, mixed evenly, made into granules, dried, and obtained granules.

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PUM

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Abstract

The invention discloses a motion sickness treatment traditional Chinese medicine pharmaceutical composition, which specifically comprises the following bulk drugs by weight: 1-18 parts of gastrodia elata, 1-12 parts of herba pogostemonis, 1-14 parts of fried atractylodes macrocephala koidz, 1-6 parts of dried ginger, 1-18 parts of caulis perillae, 1-12 parts of cassia twig, 1-12 parts of tuckahoe, 1-12 parts of pinellia ternata processed with ginger, 1-12 parts of cynanchum otophyllum, 1-12 parts of caulis bambusae in taenian, 1-12 parts of pericarpium citri reticulatae, 1-10 parts of acanthopanax senticosus, 1-8 parts of clove, 1-8 parts of coptis chinensis, and 1-12 parts of gardenia jasminoides ellis. The invention further provides a preparation method of the pharmaceutical composition. According to the present invention, the motion sickness treatment traditional Chinese medicine pharmaceutical composition is suitable for dizziness, nausea, vomiting and other symptoms and prevents and treats sea sickness, carsickness and other diseases, and the treatment principle is dampness eliminating with aromatics, qi regulating-phlegm removing, and adverse rising calming.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating motion sickness. Background technique [0002] Motion sickness is a general term for motion sickness, seasickness, airsickness, and diseases caused by swinging, bumping, rotating, and accelerated motion caused by various reasons. China is one of the countries with the highest incidence of "motion sickness" in the world, and 80% of people have experienced different degrees of motion sickness. There is currently no cure for this disease, so developing a drug with low toxicity and clear efficacy has become an urgent problem to be solved by those skilled in the art. [0003] From the perspective of the pathogenesis of motion sickness, controlling the occurrence and development of symptoms and improving collective tolerance are the keys to preventing and treating motion sickness. The main mechanism of these symptoms...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61P1/08
CPCA61K36/076A61K36/254A61K36/284A61K36/53A61K36/535A61K36/54A61K36/61A61K36/65A61K36/71A61K36/718A61K36/744A61K36/752A61K36/8888A61K36/8988A61K36/899A61K36/9068A61K2236/331A61K2236/333A61K2300/00
Inventor 李峰马捷王玥琦张炜悦韩晨霞
Owner BEIJING UNIV OF CHINESE MEDICINE
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