Composition for vectorizing an anti-cancer agent

A technology of composition and medicament, applied in the field of compositions carrying anti-cancer medicaments, can solve problems such as ineffectiveness

Active Publication Date: 2016-12-21
GUERBET SA
View PDF12 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, they are not sufficiently potent after injection, since a substantial part of the amount

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Composition for vectorizing an anti-cancer agent
  • Composition for vectorizing an anti-cancer agent
  • Composition for vectorizing an anti-cancer agent

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0181] 1. Preparation of the composition in the form of an emulsion according to the invention

[0182] 1.1. Lipiodol Emulsions with anthracyclines

[0183] 50mg doxorubicin (Amycin injection ) in 2.5ml of the third generation 250 (250mg iodine / ml). After 30 seconds of manual stirring for good dissolution, the resulting solution was removed with a 20 ml Luer lock syringe. The syringe is then placed on the three-way stopcock.

[0184] PGPR (1% w / v total solution, 100 mg - Interchim) was dissolved in 7.5 ml lipiodol by manual stirring middle.

[0185] The resulting oil was removed with a 20 ml luer lock syringe also placed on a three-way stopcock at 90°C. Start with water and oil, and perform 34 back and forth with medium strength, that is, 17 backward and forward movements.

[0186] For these emulsions, the volume of the aqueous phase and the selected lipid phase were 2.5 ml (ie 25% v / v) and 7.5 ml (ie 75% v / v) respectively. The aqueous phase / lipid ratio is 1 / 3. ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Sizeaaaaaaaaaa
Viscosityaaaaaaaaaa
Login to view more

Abstract

The invention relates to a stable water-in-oil emulsion composition containing: 20% to 40% (v/v) aqueous phase in the form of droplets and containing an anti-cancer agent; and 60% to 80% (v/v) lipid phase containing an iodized oil and at least one surfactant, having Formula (I), in a proportion, of surfactant mass relative to the total volume of the composition, of 0.3% to 5%, formula (I) for said surfactant being the following in which: s has a value of 0 or 1; m is a whole number from 2 to 30; R1 is a Formula (II) grouping wherein n is a whole number from 4 to 10, o is a whole number from 1 to 4, p is a whole number from 3 to 7; q is a whole number from 2 to 10, and r has a value of 0 or 1; R2 is a hydrogen atom or is identical to R1; and each R3 is, separately, a hydrogen atom or is identical to R1. The invention also relates to an emulsion obtained from said composition, to the preparing method thereof, and to the use thereof for treating cancer and the metastases thereof.

Description

technical field [0001] The present invention relates to a composition for the delivery of an anticancer agent comprising lipiodolized oil and a surfactant useful for preparing a composition in the form of a water-in-oil emulsion comprising an anticancer agent, Lipiodol and the surfactant. Background technique [0002] For more than a century, iodized oils (such as the product lipiodol ) has been used as a contrast product in radiological examinations such as lymphography or for the diagnosis of liver lesions. Lipiodol Mainly composed of ethyl esters of iodinated fatty acids of poppy oil. [0003] These iodized oils have been used in interventional radiology for over thirty years. Lipiodol is characterized by its tendency to be selectively taken up by liver tumors. Therefore, it has been suggested as a carrier of anticancer agents for the treatment of hepatocellular carcinoma in a technique called transarterial chemoembolization (TACE) (Nakamura et al., Radiology, 19...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/704A61K9/00A61K47/14A61K9/107A61K47/44A61P35/00A61K49/00A61K51/12
CPCA61K9/0019A61K47/14A61K47/44A61K31/704A61K49/0461A61K9/107A61P35/00A61P35/04A61K49/0447A61K31/407A61K33/26A61K51/1217
Inventor 卡罗琳·罗比克让-费朗索瓦·迈耶
Owner GUERBET SA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap