3D printing PCL/beta-TCP composite material and preparation method, application and printing method thereof

A composite material, 3D printing technology, applied in the fields of additive processing, medical science, tissue regeneration, etc., can solve problems such as reducing negative effects, and achieve the effects of reducing negative effects, avoiding secondary operations, and good biodegradability

Inactive Publication Date: 2017-01-18
SHENZHEN EXCELLENT TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the biodegradability of the above-mentioned bone scaffold materials needs to be further improved, and the negative impact after implantation needs to be further reduced

Method used

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  • 3D printing PCL/beta-TCP composite material and preparation method, application and printing method thereof
  • 3D printing PCL/beta-TCP composite material and preparation method, application and printing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] A 3D printing PCL / β-TCP composite material, the raw material contains the following components by weight percentage:

[0043] Beta-tricalcium phosphate 95%

[0044] Polycaprolactone 5%

[0045] Prepared by:

[0046] (1) Take by weighing β-tricalcium phosphate and polycaprolactone that quality is 9.5g, 0.5g respectively;

[0047] (2) Add β-tricalcium phosphate into 60mL of chloroform, stir and mix in a constant temperature magnetic stirrer at 30°C for 10min, and the stirring speed is 300rpm;

[0048] (3) Add polycaprolactone to the CHCl of the above-mentioned β-tricalcium phosphate 3 In the suspension, continue magnetic stirring at 18°C ​​for 180 minutes to fully dissolve the polycaprolactone;

[0049] (4) Adjust the temperature of the constant temperature magnetic stirrer to 60°C, continue magnetic stirring for 180min, and make CHCl 3The composite material is obtained by rapid evaporation.

Embodiment 2

[0051] A 3D printing PCL / β-TCP composite material, the raw material contains the following components by weight percentage:

[0052] Beta-tricalcium phosphate 40%

[0053] Polycaprolactone 60%

[0054] Prepared by:

[0055] (1) Take by weighing β-tricalcium phosphate and polycaprolactone that quality is 4.0g, 6.0g respectively;

[0056] (2) Add β-tricalcium phosphate into 40mL of chloroform, stir and mix in a constant temperature magnetic stirrer at 18°C ​​for 30min, and the stirring speed is 800rpm;

[0057] (3) Add polycaprolactone to the CHCl of the above-mentioned β-tricalcium phosphate 3 In the suspension, continue magnetic stirring at 30°C for 60 minutes to fully dissolve the polycaprolactone;

[0058] (4) Adjust the temperature of the constant temperature magnetic stirrer to 40°C, continue magnetic stirring for 40min, and make CHCl 3 The composite material is obtained by rapid evaporation.

Embodiment 3

[0060] A 3D printing PCL / β-TCP composite material, the raw material mainly contains the following components by weight percentage:

[0061] Beta-tricalcium phosphate 45%

[0062] Polycaprolactone 55%

[0063] Prepared by:

[0064] (1) Take by weighing β-tricalcium phosphate and polycaprolactone that quality is 4.5g, 5.5g respectively;

[0065] (2) Add β-tricalcium phosphate into 60mL of chloroform, stir and mix in a constant temperature magnetic stirrer at 20°C for 5min, and the stirring speed is 500rpm;

[0066] (3) Add polycaprolactone to the CHCl of the above-mentioned β-tricalcium phosphate 3 In the suspension, continue magnetic stirring at 25°C for 30 minutes to fully dissolve the polycaprolactone;

[0067] (4) Adjust the temperature of the constant temperature magnetic stirrer to 70°C, continue magnetic stirring for 100min, and make CHCl 3 The composite material is obtained by rapid evaporation.

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Abstract

The invention provides a 3D printing PCL / beta-TCP composite material and a preparation method, application and a printing method thereof. The 3D printing PCL / beta-TCP composite material is mainly prepared from, by weight, beta-tricalcium phosphate 40-95% and polycaprolactone 5-60%, wherein the mass percentage sum of the two raw materials is 100% or below. After the composite material is implanted, bone tissue regeneration can be promoted, and the material has a good bone repair effect. In addition, the PCL / beta-TCP composite material further has good biodegradable properties, the negative impact of a long-term implant can be reduced, secondary operation is avoided, and the material can be well applied to 3D printing.

Description

technical field [0001] The invention relates to the field of composite materials, in particular to a 3D printing PCL / β-TCP composite material and its preparation method, application and printing method. Background technique [0002] 3D printing technology is a special printing technology, which is based on the spatial data of the model, using metal or powder and other bondable materials, which are stacked through layer-by-layer printing, and finally "print" a three-dimensional object with the same proportion as the model in the computer. Model. 3D printing technology first appeared in the late 1980s, gradually matured after 2010, and quickly became popular all over the world. After entering the Chinese market, it was quickly welcomed by consumers because of its convenient and trendy features. From ordinary cartoon characters, models or artworks such as sand tables, to printing vehicles such as cars and airplanes, and even using human cells to print normal liver tissue, 3D p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/58A61L27/50A61L27/12A61L27/18B33Y10/00B33Y70/00
CPCA61L27/12A61L27/18A61L27/50A61L27/58A61L2430/02B33Y10/00B33Y70/00C08L67/04
Inventor 张东锋赵小文赖文苏冬冬吴小丽
Owner SHENZHEN EXCELLENT TECH
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