Traditional Chinese medicine combination for angina pectoris treatment and preparation method thereof
A composition and technology for angina pectoris, applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve problems such as treating the symptoms but not the root cause, and achieve the effect of high cure rate, exact drug effect, and quick effect
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Embodiment 1
[0033] (1) A Chinese medicine for the treatment of angina pectoris, which is formed by the proportioning of the following raw materials by weight:
[0034] 30 parts of longan longan, 25 parts of big-leaved nansu, 20 parts of red-backed osmanthus, 15 parts of cardamom shell, 15 parts of Lei Gonglian, 10 parts of hazelnut flower, 10 parts of horseradish grass, 10 parts of houttuynia cordata, and 10 parts of macroalgae 5 parts, 5 parts of Ginkgo biloba, 5 parts of Salvia miltiorrhiza.
[0035] (2) Preparation method:
[0036] In the first step, Daye Nansu and Hongbeigui are mixed in proportion, extracted twice with n-propanol with an alcohol concentration of 70% equivalent to twice the mass of the mixture, and the filtrates are combined, concentrated under reduced pressure, dried and pulverized into powder , followed by purification with ethanol for 1-2 times, combining the extracts, recovering the ethanol under reduced pressure and concentrating to a paste with a relative densi...
Embodiment 2
[0041] (1) a kind of Chinese medicine for the treatment of angina pectoris, is formed by the proportioning of following crude drugs by weight: with embodiment 1.
[0042] (2) Preparation method:
[0043]In the first step, Daye Nansu and Hongbeigui are mixed in proportion, extracted twice with n-propanol with an alcohol concentration of 70% equivalent to twice the mass of the mixture, and the filtrates are combined, concentrated under reduced pressure, dried and pulverized into powder , then purified once with ethanol, combined extracts, recovered ethanol under reduced pressure and concentrated to a paste with a relative density of 1.21-1.24 at 60°C, dried and pulverized into powder;
[0044] The second step is to extract cardamom shells, triptoliana, Rhizoma chinensis, and horseradish with n-propanol with an alcohol concentration of 80% twice, combine the extracts, concentrate under reduced pressure, dry, and pulverize into powder. The final powder was dissolved by adding 2 t...
Embodiment 3
[0048] 1. Long-term toxicity test process:
[0049] Apply Wistar rats (Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. provides) experimental medicine is set to high, medium and low three dosages, be respectively the capsule 8g / kg, 4g / kg, 2g of embodiment 1 formula / kg. Calculated according to the human dose of 0.1g / kg / day tablet, it is 80 times, 40 times and 20 times of the effective dose for human respectively; another control group is set up, which is given continuously for 90 days and 180 days by intragastric administration and part of the animals are withdrawn for 10 days. Days later, the effects on various physiological and biochemical indicators of rats were observed. The experimental results show that: continuous oral administration of different doses to rats for 180 days has no effect on the food intake and weight growth of the rats. No significant toxic effects were found on liver and kidney function. There was no obvious effect on blood routine, bl...
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