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A kind of vitamin b12 special chromatography resin, layer spreading agent and purification method thereof
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A purification method and B12 technology, applied in the field of medicine, can solve the problems of reduced product yield, inability to effectively remove impurities, inability to produce high-purity vitamin B12, etc., and achieve the effect of improving the separation degree
Active Publication Date: 2019-08-09
HEBEI HUARONG PHARMA
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Problems solved by technology
When the content of impurities in the vitamin B12 feed liquid is high, even if the above process is used, the impurities cannot be effectively removed, so that the product yield is further reduced, and it is impossible to produce high-purity vitamin B12 with impurities less than 1%.
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Embodiment 1
[0030] (1) Chromatographic resin formula for vitamin B12:
[0048] A preparation method comprising the steps of:
[0049] The preparation steps are the same as in Example 1.
[0050] Its pore diameter was measured to be 100A°, and the particle size was 0.7mm.
[0051] (2) A special spreading agent for vitamin B12, which is 10% by volume acetoneaqueous solution, and its pH is adjusted to 9.
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Abstract
The invention relates to a special chromatographic resin, spreading agent and purifying method for vitamin B12. Cooperation of the special separation effect of the special chromatographic resin for the vitamin B12 on the vitamin B12 with the special spreading agent makes the separation degree of the main component and impurities of the vitamin B12 be greatly improved, and a highly-pure vitamin B12 product is separated through liquid chromatogram detection. The workshop yield before purification using the resin is about 80%, and the workshop yield after purification using the resin is about 85%, so the yield is improved by 5%. 40% of Highly-pure vitamin B12 with the impurity content being smaller than 1% can be prepared in every batch. A liquid chromatogram detection result shows that the chromatographic purity of a material with fewest impurities can reach 99.6%.
Description
technical field [0001] The invention relates to a special chromatography resin, a spreading agent and a refining method, in particular to a vitamin B12 special chromatography resin, a spreading agent and a refining method of vitamin B12, belonging to the technical field of medicine. Background technique [0002] Vitamin B12, also known as cobalamin, is the only vitamin containing metal elements. Vitamin B12 in nature is synthesized by microorganisms, and higher animals and plants cannot produce vitamin B12. The main physiological function of vitamin B12 is to participate in the manufacture of bone marrow red blood cells to prevent pernicious anemia; to prevent the destruction of brain nerves. Vitamin B12 is a polycyclic compound containing trivalent cobalt. Four reduced pyrrole rings are linked together to form a corrin macrocycle (similar to porphyrin), which is the core of the vitamin B12 molecule. Vitamin B12 is obtained through strain cultivation and fermentation. In ...
Claims
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