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Trajenta tablet composition and preparation method thereof

A technology of linagliptin tablet and composition, applied in the field of linagliptin tablet composition and preparation thereof, can solve problems such as disadvantages, and achieve the effect of solving the problem of debris

Inactive Publication Date: 2017-02-15
DISHA PHARMA GRP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This all brings disadvantages to the preparation of excellent preparations

Method used

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  • Trajenta tablet composition and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0021] Embodiment 1, linagliptin 5g, mannitol 80g, polyethylene glycol 8000 25g, lactose 15g, pregelatinized starch 46g, povidone k30 5g, magnesium stearate 1.8g, wherein, linagliptin's The particle size range is D90=10μm, and 1000 tablets are prepared according to the method described in the technical scheme.

Embodiment 2

[0022] Embodiment 2, Linagliptin 5g, mannitol 150g, polyethylene glycol 8000 10g, lactose 20g, pregelatinized starch 10g, povidone k30 16g, magnesium stearate 1.8g, wherein, the The particle size range is D90=50μm, prepare 1000 tablets according to the method described in the technical proposal, and prepare 1000 tablets according to the method described in the technical proposal.

Embodiment 3

[0023] Embodiment 3, Linagliptin 5g, mannitol 90g, polyethylene glycol 8000 13g, lactose 15g, pregelatinized starch 15g, povidone k30 8g, magnesium stearate 1.8g, wherein, the The particle size range is D90=20μm, and 1000 tablets are prepared according to the method described in the technical scheme.

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Abstract

The invention relates to a Trajenta tablet composition and a preparation method thereof, and belongs to the technical field of medicines. The Trajenta tablet composition is technically characterized in that every 1000 pieces of composition contain 5g of Trajenta, 80 to 150g of mannitol, 10 to 25g of polyethylene glycol 8000, 15 to 20g of lactose, 10 to 46g of pregelatinized starch, 5 to 16g of povidone k30, and 1.8g of magnesium stearate, wherein the particle size of the Trajenta is D90=10 to 50mu m. By adopting the technical scheme, the tablet composition with high dissolution rate is provided.

Description

technical field [0001] The invention relates to a linagliptin tablet composition and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Linagliptin (linagliptin, structural formula shown below) is a potent and selective inhibitor of dipeptidyl peptidase 4 (DPP-4). DPP-4 can degrade incretin hormone-like polypeptide-1 (GLP- 1) and glucose-dependent insulinotropic polypeptide (GIP). Linagliptin increases the concentration of the active incretin hormone, stimulates insulin release in a glucose-dependent manner, and decreases circulating glucagon levels. In addition, GLP-1 can also reduce the glucagon secretion of pancreatic α cells and reduce the output of hepatic glucose. [0003] [0004] Linagliptin structural formula [0005] Linagliptin tablets combined with metformin and sulfonylureas, combined with diet control and exercise, can be used to control blood sugar in adult patients with type 2 diabetes. From the per...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/522A61K47/36A61K47/26A61K47/10A61K47/32A61K47/12A61P3/10
CPCA61K9/2013A61K9/2018A61K9/2027A61K9/2031A61K9/2059A61K31/522
Inventor 姚芳徐敏霞侯铁强白莉杨豪伟
Owner DISHA PHARMA GRP