Topical cosmetic compositions
A composition, technology for topical use in the field of topical compositions
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Embodiment 1
[0108] Formulations containing the ingredients disclosed herein are formulated as topical skin and / or hair compositions. As a non-limiting example, the formulations in Table 1 were prepared as eye creams.
[0109] All compositions disclosed and claimed herein can be made and implemented in light of the present disclosure without undue experimentation. While the compositions and methods of the present invention have been described in terms of preferred embodiments, changes may be made in the compositions and in the steps or sequence of steps of the methods described herein without departing from the inventive concept, The spirit and scope will be apparent to those skilled in the art. More specifically, it is apparent that certain reagents, both chemically and physiologically related, could be substituted for the reagents described herein while achieving the same or similar results. All such similar substitutes and modifications apparent to those skilled in the art are deemed ...
Embodiment 2
[0115] (In Vitro Efficacy of Active Ingredients)
[0116] The potency of ingredients is determined by the following method. The following are non-limiting assays that can be used in the context of the present invention. It should be appreciated that other testing procedures may be used including, for example, objective and subjective procedures.
[0117] Centella asiatica extract was determined to promote hyaluronic acid synthesis, increase laminin production, inhibit melanin production, and decrease tyrosinase activity. It was also determined that Centella asiatica meristem cell cultures increased hyaluronic acid production and decreased tyrosinase activity. It was determined that lotus magnolia bark extract inhibits tumor necrosis factor alpha (TNFα), has antioxidant capacity, increases laminin production, and inhibits melanin production. It was determined that Magnolia officinalis bark extract provides antioxidant capacity, inhibits melanin production, inhibits expressio...
Embodiment 3
[0152] (Clinical Efficacy of Composition)
[0153] Appearance and Condition of Skin Around the Eyes - The compositions described in Table 1 have been shown in volunteer subjects to: increase skin firmness and elasticity; improve skin texture and clarity; reduce fine lines and / or wrinkles, Eye bags, dark circles, fine lines and sagging; improves the overall appearance of the eye area. The purpose of this study was to evaluate the efficacy of the compositions in Table 1 on aged / photoaged skin in the eye area. The study evaluated skin by visual grading and bioinstrumental measurements. It was determined that the compositions in Table 1 statistically increased skin firmness after 4 weeks of treatment and this increase was also detected at 12 weeks. The net elasticity of the skin also increased statistically at week 8. After 12 weeks, the following significant improvements were observed compared to baseline: improved skin texture and clarity; reduced fine lines and / or wrinkles, ...
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