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Solid disperse granules for treating peptic ulcers

A peptic ulcer and solid dispersion technology, which is applied to the digestive system, medical preparations containing active ingredients, plant/algae/fungus/moss components, etc., can solve the problems of high cost, high medicinal taste, and large amount of medicinal materials. Fewer side effects, improved anti-ulcer activity, ideal pain relief effect

Inactive Publication Date: 2017-02-22
门源县雪草木生物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned prescriptions have more medicinal flavors, a larger amount of medicinal materials, and higher costs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The preparation of embodiment 1 pharmaceutical composition of the present invention

[0026] Zushima 2g, Atractylodes macrocephala 10g, Ganoderma lucidum 3g, Codonopsis 8g, Pseudostellaria 8g, capillary 8g, dandelion 10g, bellflower 5g, patchouli 5g, nutmeg 4g; after drying, crush to 250 mesh and mix well to get Raw drug powder.

[0027] Take raw drug powder: polyethylene glycol-6000=1:3w / w, mix well, heat until polyethylene glycol-6000 is in a molten state, stir, immediately place in 0°C environment and quench until solidified, crush to obtain Solid dispersion.

[0028] Take the solid dispersion: dextrin = 1:2w / w, use water as the binder, and wet granulate to obtain solid dispersion granules.

Embodiment 2

[0029] The preparation of embodiment 2 pharmaceutical compositions of the present invention

[0030] Zushima 2g, Atractylodes macrocephala 10g, Ganoderma lucidum 3g, Codonopsis 8g, Pseudostellaria 8g, capillary 8g, dandelion 10g, bellflower 5g, patchouli 5g, nutmeg 4g; after drying, crush to 250 mesh and mix well to get Raw drug powder.

[0031] Take raw drug powder: polyethylene glycol-6000=1:3w / w, mix well, heat until polyethylene glycol-6000 is in a molten state, stir, immediately place in 0°C environment and quench until solidified, crush to obtain Solid dispersion.

[0032] Take solid dispersion: starch=1:3w / w, use starch slurry as binder, wet granulate to obtain solid dispersion granules.

[0033] Typical case 1

[0034] Li, male, 26 years old, had epigastric discomfort after eating, accompanied by belching, pantothenic acid, and occasional vomiting, and the symptoms had lasted for 2 months. After diagnosis, it was confirmed as chronic superficial gastritis.

[0035...

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Abstract

The invention relates to solid disperse granules for treating peptic ulcers. The solid disperse granules are prepared from 1 part by weight of solid dispersoids and 1-3 parts by weight of filler, wherein the solid dispersoids are prepared from raw material medicine powder of polyethylene glycol-6000 equal to (1-2):(3-5) w / w; the raw material medicine powder is prepared by smashing raw material medicine of, by weight, 1-3 parts of girald daphne bark, 7-13 parts of rhizoma atractylodis macrocephalae, 2-3 parts of ganoderma, 5-10 parts of radix codonopsis, 5-10 parts of radix pseudostellariae, 5-10 parts of herbal artemisiae scopariae, 5-10 parts of herbal taraxaci, 3-7 parts of radix platycodonis, 3-7 parts of herbal pogostemonis and 2-4 parts of myristica fragrans to be of 200-500 mesh. The raw material medicine powder is prepared into solid dispersoids, the bioavailability of the drug is improved, and the anti-ulcer activity is obviously improved. However, the solid dispersoids have an excessively large specific surface area, absorb damp easily and are not suitable for storage and production, poor in fluidity and not convenient to produce and package. Thus, the solid dispersoids are prepared into the granules which facilitate storage, transportation and packaging of products and are convenient to use by patients.

Description

technical field [0001] The invention relates to a solid dispersion granule for treating peptic ulcer. Background technique [0002] Gastric and duodenal ulcers refer to localized round or oval full-thickness defects of gastric and duodenal mucosa, the muscularis mucosae is penetrated, and fibrous scars inevitably remain after healing, with a layer of epithelium on the surface Overlying, the muscularis mucosa cannot regenerate. The etiology can be summed up as the self-digestion of gastric mucosa by gastric acid and pepsin or the destruction of gastric mucosal barrier due to various reasons. In recent years, it has been considered that the formation of ulcers has an important relationship with Helicobacter pylori infection in the stomach. [0003] Chronic superficial gastritis is a disease of chronic superficial inflammation of the gastric mucosa. It is a common disease of the digestive system and belongs to chronic gastritis. It can be caused by alcoholism, strong coffee,...

Claims

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Application Information

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IPC IPC(8): A61K36/83A61K9/16A61K9/14A61P1/04
CPCA61K36/83A61K9/146A61K9/1652A61K36/074A61K36/185A61K36/282A61K36/284A61K36/288A61K36/344A61K36/346A61K36/36A61K36/53A61K2300/00
Inventor 徐继锋许婧
Owner 门源县雪草木生物药业有限公司
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