Ruthenium complex loaded mesoporous silicon nanoparticles as well as preparation method and application thereof
A technology of ruthenium complexes and nanoparticles, which is applied in the field of medicine, can solve the problems of high toxicity and side effects and poor tumor targeting, and achieve the effects of improving targeting, reducing toxicity and side effects, and realizing controlled release and targeted transportation
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Embodiment 1
[0044] This embodiment provides a method for synthesizing RuNPs loaded with ruthenium complex mesoporous silicon nanoparticles, such as figure 1 shown, including the following steps:
[0045] S1. Preparation of nano-mesoporous silicon spheres MSNs: Take 2.0 g of cetyltrimethylammonium bromide and 50 μL of triethylamine in 20 mL of water at 95 ° C for 1 h under reflux reaction, then add 1.5 mL of tetraethyl orthosilicate dropwise, continue Reflux reaction for 1 hour, filter with suction, wash with water, reflux the obtained solid product in formic acid alcohol solution for 6 hours, centrifuge, and dry in vacuum to obtain nanometer mesoporous silicon sphere MSNs.
[0046] S2. Take 100 mg of nano-mesoporous silicon spheres MSNs described in step S1 and add them to 10 mL of acetonitrile solution containing 10 mg / mL of the ruthenium complex RuNHC, stir at room temperature for 24 hours in the dark, then centrifuge and vacuum-dry to obtain the ruthenium complex loaded Nano-mesoporou...
Embodiment 2
[0050] This embodiment provides a method for synthesizing RuNPs loaded with ruthenium complex mesoporous silicon nanoparticles, such as figure 1 described, including the following steps:
[0051] S1. Preparation of nano-mesoporous silicon spheres MSNs: Take 1.0 g of cetyltrimethylammonium bromide and 20 μL of triethylamine in 10 mL of water at 90 ° C for 1.5 h under reflux, then add 1.0 mL of tetraethyl orthosilicate dropwise, Continue the reflux reaction for 0.5h, filter with suction, wash once with water, reflux the collected solid product in formic acid alcohol solution for 3h, centrifuge, and dry in vacuum to obtain nanometer mesoporous silicon sphere MSNs.
[0052] S2. Take 150 mg of nano-mesoporous silicon spheres MSNs described in step S1 and add them to 15 mL of acetonitrile solution containing 15 mg / mL of the ruthenium complex RuNHC, stir at room temperature for 36 h in the dark, then centrifuge and vacuum-dry to obtain the ruthenium complex loaded Nano-mesoporous si...
Embodiment 3
[0056] This embodiment provides a method for synthesizing RuNPs loaded with ruthenium complex mesoporous silicon nanoparticles, such as figure 1 described, including the following steps:
[0057] S1. Preparation of nano-mesoporous silicon spheres MSNs: take 3.0 g of cetyltrimethylammonium bromide and 100 μL of triethylamine in 30 mL of water at 100 ° C for 1 h under reflux reaction, and then add 2.0 mL of ethyl orthosilicate dropwise, Reflux for 1.5 hours, filter with suction, wash twice with water, reflux the obtained solid product in formic acid alcohol solution for 9 hours, centrifuge, and dry in vacuum to obtain nanometer mesoporous silicon spheres MSNs.
[0058] S2. Add 50 mg of nano-mesoporous silicon spheres MSNs described in step S1 into 5 mL of acetonitrile solution containing 5 mg / mL of the ruthenium complex RuNHC, stir for 12 hours at room temperature in the dark, then centrifuge and vacuum-dry to obtain the ruthenium complex loaded Nano-mesoporous silicon spheres ...
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