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Eurycoma longifolia Jack extract and eurycomanone and preparation method and use thereof

A technology of extract and ketone, which is applied in the field of medicine, can solve the problems of incompletely clear mechanism of influence and limited application

Inactive Publication Date: 2017-03-08
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although Tongkat Ali has great medicinal value, there are still no relevant reports about its anti-gout and anti-tumor at home and abroad, which greatly limits its application.
[0003] Eurycomanone, the main component of Tongkat Ali, can increase the fertility rate of mice by increasing testosterone and sperm formation in mice, but the mechanism of effect is not completely clear

Method used

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  • Eurycoma longifolia Jack extract and eurycomanone and preparation method and use thereof
  • Eurycoma longifolia Jack extract and eurycomanone and preparation method and use thereof
  • Eurycoma longifolia Jack extract and eurycomanone and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Tongkat Ali root 4kg, heated and extracted three times at 80°C with 12 times, 10 times and 8 times of 35% alcohol after crushing, (3 hours for the first time, 2 hours for the second time, 2 hours for the third time), filtered and combined The filtrate was recovered from the solvent to obtain the extract, and the yield was 12%.

Embodiment 2

[0027] Tongkat Ali root bark 4kg, crushed and extracted three times with 12 times, 10 times and 8 times of 50% alcohol at room temperature, (4 hours for the first time, 4 hours for the second time, 3 hours for the third time) filter, The filtrates were combined, and the solvent was recovered to obtain an extract with a yield of 11%.

Embodiment 3

[0029] Tongkat Ali stem 4kg, heated and extracted three times at 80°C with 12 times, 10 times and 8 times of 60% alcohol after crushing, (4 hours for the first time, 3 hours for the second time, 3 hours for the third time) filtered, combined The filtrate was recovered from the solvent to obtain the extract, and the yield was 15%.

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Abstract

The invention belongs to the technical field of medicines, relates to eurycoma longifolia Jack extract and eurycomanone and a preparation method thereof, and also relates to use of the eurycomanone and the eurycoma longifolia Jack extract and a composition containing the eurycomanone and the eurycoma longifolia Jack extract in preparing of anti-tumor, anti-gout and anti-hyperuricemia drugs, health food, functional food and food. The eurycoma longifolia Jack extract is obtained by taking a dry eurycoma longifolia Jack medicinal material, extracting with water or alcohol, concentrating liquid extract, recovering a solvent and drying. The eurycomanone is obtained by using a solvent for gradient elution of the eurycoma longifolia Jack extract by silica gel column chromatography. Refined high purity target compound eurycomanone can be obtained by recrystallization treatment when necessary (when the eurycomanone contains a small amount of impurities or pigments and the like).

Description

technical field [0001] The present invention belongs to the technical field of medicine, relates to Tongkat Ali extract and its preparation method, ketone and its preparation method, and also relates to the use of ketone, Tongkat Ali extract and the composition containing them in the preparation of anti-tumor, anti-tumor Drugs for gout and hyperuricemia, health food, functional food, and food applications. Background technique [0002] Tongkat Ali (Eurycoma longifolia Jack.), also known as Tongkat Ali, is a plant of the genus Eurycoma in the bitter wood family, a wild shrub that grows in the moist sandy soil of the primitive tropical rainforest near the equator, and is mainly distributed in Malaysia, Indonesia, Thailand, Vietnam, and Laos , Cambodia and other Southeast Asian countries. Its extracts (especially the roots) have significant curative effects in the treatment of male sexual dysfunction and other diseases; in addition, it also has antipyretic, physical strength, ...

Claims

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Application Information

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IPC IPC(8): A61K36/185C07D493/10A61K31/366A23L33/105A61P35/00A61P19/06
Inventor 孟大利王子豪刘炫利张建华
Owner SHENYANG PHARMA UNIVERSITY
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