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Allogenic decalcified bone and silica-gel particle combined material for nose plastic filling and preparation method of such material

An allogeneic, silicone particle technology, used in prostheses, nose implants, medical science, etc., can solve the problems of complex production process, prone to displacement and wear, etc., to prevent pain and prevent movement.

Inactive Publication Date: 2017-03-08
大连裕辰科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention provides a material and a preparation method for nasal plastic filling allogeneic decalcified bone joint silica gel particles, so as to solve the problems in the prior art that the production process is relatively complicated and prone to displacement and wear.

Method used

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  • Allogenic decalcified bone and silica-gel particle combined material for nose plastic filling and preparation method of such material
  • Allogenic decalcified bone and silica-gel particle combined material for nose plastic filling and preparation method of such material
  • Allogenic decalcified bone and silica-gel particle combined material for nose plastic filling and preparation method of such material

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preparation example Construction

[0042] refer to image 3 As shown, the present invention also proposes a preparation method for filling allogeneic decalcified bone joint silica gel particles for rhinoplasty, comprising the following steps:

[0043] A) matrix production, using silica gel particles to make the nasal bone matrix;

[0044] B) taking bone and obtaining allogeneic cartilage in a sterile environment;

[0045] C) treatment, degreasing, decalcifying, deproteinizing and sterilizing the obtained allogeneic cartilage in sequence;

[0046] D) culturing, assembling the treated allograft cartilage in step C onto the nasal bone matrix, and culturing for 24 hours,

[0047] E) Carve, carve the nasal bone matrix into the required shape after the cultivation in step D).

[0048] Concrete processing in the step C of the present invention comprises:

[0049](1) immersing the allograft cartilage in a mixed liquid of chloroform and methanol for 6-24 hours; wherein: the volume ratio of chloroform and methanol in...

Embodiment 1

[0055] 1. The nasal bone matrix is ​​made of silica gel particles, and there are many hollow holes on the nasal bone matrix;

[0056] 2. Obtain allogeneic rib cartilage in a sterile environment; preferably remove the ribs (number of segments, length), clean and soak in distilled water;

[0057] 3. Immerse the allogeneic cartilage in a mixed liquid of chloroform and methanol for 24 hours to degrease; wherein: the volume ratio of chloroform and methanol in the mixed liquid of chloroform and methanol is 1:1, and wash it with distilled water after taking it out;

[0058] 4. Immerse the degreased allograft cartilage in a hydrochloric acid solution with a concentration of 0.5mol / L, and keep stirring for 12 hours for decalcification, and wash it with distilled water after taking it out;

[0059] 5. Immerse the decalcified allogeneic cartilage in a mixed solution of TritonX-100 and ammonia water for 72 hours to deproteinize; wherein, the volume percentage of TritonX-100 in the mixed s...

Embodiment 2

[0064] 1. The nasal bone matrix is ​​made of silica gel particles, and there are many hollow holes on the nasal bone matrix;

[0065] 2. Obtain allogeneic ear cartilage in a sterile environment; clean and soak in distilled water;

[0066] 3. Immerse the allogeneic cartilage in a mixed liquid of chloroform and methanol for 24 hours to degrease; wherein: the volume ratio of chloroform and methanol in the mixed liquid of chloroform and methanol is 1:1, and wash it with distilled water after taking it out;

[0067] 4. Immerse the degreased allograft cartilage in a hydrochloric acid solution with a concentration of 0.6mol / L, and keep stirring for 12 hours for decalcification, and wash it with distilled water after taking it out;

[0068] 5. Immerse the decalcified allogeneic cartilage in a mixed solution of TritonX-100 and ammonia water for 72 hours to deproteinize; wherein, the volume percentage of TritonX-100 in the mixed solution of TritonX-100 and ammonia water is 1 %, the mas...

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Abstract

The invention relates to an allogenic decalcified bone and silica-gel particle combined material for nose plastic filling and a preparation method of such material. The allogenic decalcified bone and silica-gel particle combined material comprises a nasal bone matrix prepared from silica-gel particles, and the nasal bone matrix comprises a nasal tip, a nasal columella and a nose bridge, wherein the nose bridge is connected with the nasal columella through the nose tip. A narrowed transition segment is arranged between the nose bridge and the nose tip and is narrower than the nose bridge, the nasal bone matrix is provided with a hollow-out body filled with an allogenic decalcified bone so as to lighten the structure, and the surface of the nasal bone matrix is distributed with a plurality of pores densely. The allogenic decalcified bone and silica-gel particle combined material has the advantages that through the design of nose bridge segments, a prosthesis can be in close contact with a nose bone, and displacement or wear is avoided; body fluid can flow into the pores in the nose bridge to promote growth of human tissues and stable integration of a nose and the nose prosthesis, and accordingly the nose prosthesis can be protected from moving, shedding and ulcerating, and postoperative pain of a patient is prevented. The preparation method is applicable to treatment of autogenous cartilages and alloplastic bones.

Description

technical field [0001] The invention relates to the technical field of plastic surgery, in particular to a material for filling allogeneic decalcified bone joint silica gel particles in rhinoplasty and a preparation method thereof. Background technique [0002] Rhinoplasty (facelift) surgery is to change the height and shape of the nose by implanting appropriate materials so that it is in harmony with other parts of the face. It is the most common surgery in the field of plastic surgery. [0003] In medicine, there are many kinds of rhinoplasty materials, such as medical silicone rubber, autologous cartilage, allogeneic cartilage, animal tendon or ligament, expanded body (polytetrafluoroethylene), hyaluronic acid, etc. There are also many preparation methods for nasal bridge prosthesis. Among them, autologous cartilage is self-sourced, so there will be no rejection and no allergies, but it is difficult to shape during the production process. Animal tendons and ligaments are...

Claims

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Application Information

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IPC IPC(8): A61L27/36A61L27/02A61F2/18
CPCA61L27/025A61L27/3612A61L27/3687A61L27/3691A61F2/186A61L2430/02
Inventor 于浩
Owner 大连裕辰科技发展有限公司
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