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Method for separating and extracting 6-gingerol from fresh ginger

An extraction method, ginger technology, applied in the field of separation and extraction of 6-gingerol in ginger, can solve the problems of easy decomposition, difficult separation, unstable chemical properties of 6-gingerol, etc., and achieve the effect of low cost and simple operation

Inactive Publication Date: 2017-03-15
CHONGQING MEDICAL & PHARMA COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the unstable chemical properties of 6-gingerol, it is easy to decompose when exposed to heat, resulting in difficulty in separation

Method used

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  • Method for separating and extracting 6-gingerol from fresh ginger

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The separation and extraction method of 6-gingerol in ginger specifically comprises the following steps:

[0028] A. Put the ginger at a temperature of 52°C, a pressure of 23MPa, CO 2 The flow rate is 21L / h to carry out supercritical extraction and dissolve the extract with ethanol, and remove the insoluble matter after filtration;

[0029] B. Add equal volumes of purified water to the filtrate obtained in step A, filter and discard the filtrate to obtain a precipitate;

[0030] C. The precipitate obtained in step B is placed in an oven and dried at a temperature of 43° C., dissolved in acetone of 1.03 times the weight of the dry precipitate and filtered to obtain a filtrate;

[0031] D. Add 100 mesh column chromatographic silica gel with 1.45 times the dry precipitation mass to the filtrate obtained in step C, stir evenly, evaporate the solvent, dry, and pulverize through a 200 mesh sieve;

[0032] E. Add thin-layer chromatography silica gel with 10 times the mass of...

Embodiment 2

[0036] The separation and extraction method of 6-gingerol in ginger specifically comprises the following steps:

[0037] A. Put the ginger at a temperature of 49°C, a pressure of 26MPa, CO 2 The flow rate is under the condition of 19L / h to carry out supercritical extraction and dissolve the extract with ethanol, and remove the insoluble matter after filtration;

[0038] B. Add equal volumes of purified water to the filtrate obtained in step A, filter and discard the filtrate to obtain a precipitate;

[0039] C. The precipitate obtained in step B is placed in an oven and dried at a temperature of 38° C., dissolved in acetone of 1.25 times the weight of the dry precipitate and filtered to obtain a filtrate;

[0040] D. Add 300 mesh column chromatographic silica gel with 1.53 times the dry precipitation mass to the filtrate obtained in step C, stir evenly, evaporate the solvent, dry, and pulverize through a 200 mesh sieve;

[0041] E. Add thin-layer chromatography silica gel wi...

Embodiment 3

[0045] The separation and extraction method of 6-gingerol in ginger specifically comprises the following steps:

[0046] A. Put the ginger at a temperature of 50°C, a pressure of 25MPa, CO 2 The flow rate is under the condition of 20L / h to carry out supercritical extraction and dissolve the extract with ethanol, and remove the insoluble matter after filtration;

[0047] B. Add equal volumes of purified water to the filtrate obtained in step A, filter and discard the filtrate to obtain a precipitate;

[0048] C. The precipitate obtained in step B is placed in an oven and dried at a temperature of 40° C., dissolved in acetone of 1.18 times the weight of the dry precipitate and filtered to obtain a filtrate;

[0049] D. Add 200-mesh column chromatography silica gel with 1.5 times the dry precipitation mass to the filtrate obtained in step C, stir evenly, evaporate the solvent, dry, and pulverize through a 200-mesh sieve;

[0050] E. Add thin-layer chromatographic silica gel wit...

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Abstract

The invention belongs to the technical field of chemical engineering, and particularly relates to a separating and extracting method for 6-gingerol in fresh ginger. The silica gel column chromatography ascending development method is used so that 6-gingerol can be individually separated from a silica gel chromatography column in quantity. The problem that due to the fact that 6-gingerol is easy to decompose when heated, 6-gingerol is difficult to separate is solved. The purity of 6-gingerol obtained through the method is 85% or more. Meanwhile, the method is convenient, fast, low in cost, easy to implement and suitable for large-scale application and popularization.

Description

technical field [0001] The invention belongs to the technical field of chemical industry, and in particular relates to a method for separating and extracting 6-gingerol from ginger. Background technique [0002] Ginger is the fresh rhizome of ginger, a perennial herb of the Zingiberaceae family, with a spicy taste and warm nature. Modern pharmacological studies have shown that ginger has antibacterial, anti-cancer, anti-oxidation, anti-aging effects, and its unique "gingerol" can effectively treat abdominal distension, abdominal pain, diarrhea, and vomiting caused by eating cold and cold food. disease. [0003] 6-gingerol is the main chemical component contained in ginger, its structure is shown in the following formula, it has anti-oxidation, [0004] [0005] Anti-tumor, anti-inflammatory, cardiotonic, antihypertensive, hypolipidemic, hypoglycemic, anticoagulant and other biological activities. However, due to the unstable chemical properties of 6-gingerol, it is eas...

Claims

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Application Information

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IPC IPC(8): C07C49/255C07C45/78C07C45/79
CPCC07C45/78C07C45/79C07C49/255
Inventor 闫志慧朱仝飞
Owner CHONGQING MEDICAL & PHARMA COLLEGE
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