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Reagent and system for evaluating postoperative prognosis and chemotherapy sensitivity of stomach cancer

A technology for sensitivity assessment and prognosis, applied in measurement devices, instruments, scientific instruments, etc., can solve problems such as differences in clinical outcomes and low efficacy, and achieve the effect of mature system, simple operation process, and objective and accurate results.

Active Publication Date: 2017-03-15
NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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Problems solved by technology

However, a large number of studies have found that even patients with the same clinical stage and the same treatment plan have great differences in their clinical outcomes
Since traditional clinicopathological diagnosis and single molecular markers are less effective in judging postoperative prognosis and chemotherapy sensitivity of patients, kits combined with multi-molecular markers will be a new research and development direction

Method used

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  • Reagent and system for evaluating postoperative prognosis and chemotherapy sensitivity of stomach cancer
  • Reagent and system for evaluating postoperative prognosis and chemotherapy sensitivity of stomach cancer
  • Reagent and system for evaluating postoperative prognosis and chemotherapy sensitivity of stomach cancer

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Embodiment 1

[0029] First, the present invention dyed 9 kinds of markers for screening, and used immunohistochemical method to detect the expression of 9 kinds of molecular markers in 251 gastric cancer paraffin sections (including normal parts, invasion margins and tumor centers) that underwent resection, And use professional image software to analyze the positive counts of different molecular markers in the normal part, invasion edge and tumor center respectively, use X-title software to obtain the cut-off value of each molecular marker, and obtain the expression of each molecular marker, Thus, 27 molecular indicators were obtained. 251 patients with gastric cancer were randomly divided into a training group and a test group, 125 cases and 126 cases respectively. The training group was used to establish the model, and the test group was used to verify whether the established model was appropriate. In the training group, five molecular indicators were obtained by using the LASSO COX regre...

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Abstract

The invention provides a reagent for evaluating postoperative prognosis and chemotherapy sensitivity of stomach cancer. The reagent comprises a first antibody for detecting CD3, a first antibody for detecting CD8, a first antibody for detecting CD45RO, a first antibody for detecting CD66b and a second antibody marked by horse radish peroxidase. The purpose of predicting prognosis and chemotherapy sensitivity of a patient after tumor is cut through operation can be achieved by comprehensively analyzing the expression levels of antigen of the four first antibodies in invasion edges and tumor centers of stomach cancer specimens. The invention provides a method for evaluating postoperative prognosis and chemotherapy sensitivity of stomach cancer, the method provided by the invention is very developed, simple, convenient and visible in operation process and easy to repeat, and can be completed by common technicians. Due to semi-automatic image quantitative analysis of artificial assistance, the result is objective and accurate and is prior to that of artificial semi-quantitative analysis. By adopting the method, the postoperative prognosis and chemotherapy sensitivity evaluation of stomach cancer can be very well evaluated.

Description

technical field [0001] The invention relates to a reagent and system for evaluating postoperative prognosis and chemotherapy sensitivity of gastric cancer. Background technique [0002] Gastric cancer (GC) is one of the most common malignant tumors in the world, ranking fourth in incidence and second in mortality. In China alone, there were 679,000 new gastric cancer patients and 498,000 gastric cancer deaths in 2015, which seriously exacerbated the global disease burden, especially in China. Gastric cancer is prone to metastasis and insensitive to chemotherapy, which are important reasons for its poor prognosis. Effective prediction of postoperative prognosis and chemotherapy sensitivity of patients with gastric cancer will enable selection of appropriate treatment groups and methods, and provide strong support for effective diagnosis and treatment. The clinical staging of gastric cancer based on the TNM (tumor, node, metastasis) system and histological classification is ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574
CPCG01N33/57446
Inventor 李国新张琪江玉明李团结陈规划祁小龙胡彦锋
Owner NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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