Soft capsule and preparation method thereof

A technology of soft capsules and capsule skins, which is applied in capsule delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc. It can solve the problems of easy shell cracking, capsule hardening, soft capsule hardening, etc., and reach the disintegration time limit Good effect of stability, maintaining elasticity and hardness, uniformity and stability

Active Publication Date: 2017-03-22
BY HEALTH CO LTD
View PDF7 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problem of soft capsule hardening and easy shell cracking, researchers have tried a variety of solutions, even if adding new plasticizers to

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Soft capsule and preparation method thereof
  • Soft capsule and preparation method thereof
  • Soft capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0036] Example 1 Preparation and detection of soft capsules

[0037] 1. The formula of the soybean phospholipid soft capsule in this embodiment is as follows:

[0038] Table 1 Example 1 Soft capsule content and rubber formula

[0039] Contents (glycerol accounts for 10%, 2:3:5 added) Rubber Soybean phospholipids: soybean oil: glycerol = 89:1:10 Glycerin: purified water: gelatin=1:2:2

[0040] 2. The preparation process of the soft capsule is as follows (the content of glycerin is added 2:3:5):

[0041] (1) Preparation of the capsule skin from the plastic tank;

[0042] (2) Preparation of soft capsule contents:

[0043] 1) When the pressure in the batching tank is -0.05MPa, the temperature is 40°C, and the stirring speed is set to 65 rpm, add the formulated amount of soybean oil into the batching tank, and add 20% of the formulated amount of glycerin while stirring. The stirring time is 5 minutes.

[0044] 2) When the mixing time is reached, open the lid of the batching tank and add 3...

Example Embodiment

[0056] Example 2 Preparation and detection of soft capsules

[0057] 1. The formula of the soybean phospholipid soft capsule in this embodiment is as follows:

[0058] Table 3 Example 2 Soft capsule content and rubber formula

[0059] Contents (Glycerin 4%, 2:3:5 added) Rubber Soybean Lecithin: Soybean Oil: Glycerin = 95:1:4 Glycerin: purified water: gelatin=1:2:2

[0060] 2. The preparation process of the soft capsule is as follows (the content of glycerin is added 2:3:5):

[0061] (1) Preparation of the capsule skin from the plastic tank;

[0062] (2) Preparation of soft capsule contents:

[0063] 1) When the pressure in the batching tank is -0.05MPa, the temperature is 40°C, and the stirring speed is set to 65 rpm, add the formulated amount of soybean oil into the batching tank, and add 20% of the formulated amount of glycerin while stirring. The stirring time is 5 minutes.

[0064] 2) When the mixing time is reached, open the lid of the batching tank and add 30% glycerin while s...

Example Embodiment

[0077] Example 3 Preparation and detection of soft capsules

[0078] 1. The formula of the soybean phospholipid soft capsule in this embodiment is as follows:

[0079] Table 5 Example 3 Soft capsule contents and rubber formula

[0080] Contents (glycerol accounts for 15%, 2:3:5 added) Rubber Soybean lecithin: soybean oil: glycerol = 84:1:15 Glycerin: purified water: gelatin=1:2:2

[0081] 2. The preparation process of the soft capsule is as follows (the content of glycerin is added 2:3:5):

[0082] (1) Preparation of the capsule skin from the plastic tank;

[0083] (2) Preparation of soft capsule contents:

[0084] 1) When the pressure in the batching tank is -0.05MPa, the temperature is 40°C, and the stirring speed is set to 65 rpm, add the formulated amount of soybean oil into the batching tank, and add 20% of the formulated amount of glycerin while stirring. The stirring time is 5 minutes.

[0085] 2) When the mixing time is reached, open the lid of the batching tank and add 30% ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to the technical field of preparations, in particular to a soft capsule and a preparation method thereof. The soft capsule comprises contents and a capsule shell, wherein the contents comprise an effective active ingredient, glycerin and a solvent. Glycerin in a specific ratio is added to the contents of the soft capsule, the elasticity and the hardness of the soft capsule shell can be effectively maintained, and the controllability purpose is achieved.

Description

technical field [0001] The invention relates to the technical field of preparations, in particular to a soft capsule and a preparation method thereof. Background technique [0002] Capsules in medicine and health food refer to capsules made of special film-forming materials (such as gelatin, cellulose, polysaccharides, etc.), and the contents (such as powder, liquid, etc.) or packed in doses into it, easy to swallow. In the field of preparation technology, powders or granules that are generally irritating to the esophagus and gastric mucosa, or drugs that have a bad taste, are easy to volatilize, are easily decomposed by saliva in the mouth, and are easy to be inhaled into the trachea need to be packed into capsules. The medicinal properties of the medicine are not destroyed, and the digestive organs and respiratory tract are also protected. Removing the capsule shell may result in drug loss, drug waste, and reduced drug efficacy. In addition, some drugs need to be dissol...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/48A61K47/10A61K31/685A61K35/50A61K36/48A61K36/488A61K35/644A61K35/65A23P10/30A23L29/00
CPCA23V2002/00A61K9/4808A61K9/4858A61K31/685A61K35/50A61K35/644A61K35/65A61K36/48A61K36/488A61K2300/00A23V2250/6406
Inventor 黄仪友李太适李泽其刘莉
Owner BY HEALTH CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap