Continuous and intelligent preparation method of liquid cooling drop pills

Abstract

The invention provides a continuous and intelligent preparation method of liquid cooling drop pills. The preparation method comprises the following steps that (1) feeding is conducted, specifically, various materials are separately weighed and conveyed; (2) melting is conducted, specifically, the materials conveyed in the step (1) are subjected to graded heating and mixing to obtain a mixture, wherein the effective component RSD in the mixture is no larger than 5%; (3) homogenization is conducted, specifically, the mixture obtained in the step (2) is pressurized and heated to obtain a homogenized material with the effective component RSD being no larger than 5%; (4) dropping is conducted, specifically, the homogenized material obtained in the step (3) is subjected to vibration dropping to obtain the drop pills, and the drop pills are conveyed after being put into cooling liquid to be cooled; and (5) deoiling is conducted, specifically, the cooling liquid on the surfaces of the drop pills conveyed in the step (4) is removed in an inclined centrifugation mode. By adoption of the continuous and intelligent preparation method, the time for the whole preparation process is shortened, higher stability and uniformity of the drop pills are ensured, and the drop pills are reasonably deoiled in the high-speed centrifugation mode, so that pollution to the drop pills is avoided, and the cyclic utilization rate of the cooling liquid is increased.

Description

Technical field [0001] The invention relates to the technical field of pharmacy, in particular to drop pill medicine manufacturing equipment, in particular to a continuous intelligent preparation method of liquid cooling drop pill. Background technique [0002] Dropping pills are a traditional dosage form in traditional Chinese medicine preparations. They are generally recognized for their short production cycle, rapid onset of action, high drug stability, and ease of carrying and storage. [0003] The existing drip pill production method is basically natural dripping combined with liquid cooling, or a pressurized dripping method improved from the natural dripping method combined with liquid cooling. The disadvantages of the prior art method are: 1. The production process takes a long time. Due to the volatilization of some volatile components in the raw materials, it is difficult to ensure the uniformity and stability of the quality of dripping pills. 2. There is no feeding syste...

AI Technical Summary

Problems solved by technology

[0003] Existing drop pill production method is natural dropping system and in conjunction with liquid cooling basically, or the pressurized dripping method improved by natural drop system method and in conjunction with liquid cooling, the defect of the method of prior art is: 1, the whole The production process takes a long time. Since the raw materials contain some volatile components, the components volatilize, and it is difficult to guarantee the quality of the dropping pills. The product quality is uniform and stable.

2. There is no feeding system, which leads to poor uniformity of the active ingredients in the dripping pills; 3. In addition, the liquid cooling method requires liquid-solid separation of the dripping pills and the cooling liquid. It is difficult to completely separate the two, so , the coolant will inevitably remain on the dripping pills, resulting in contamination of the dripping pills

4. When it is necessary to adjust the output, the traditional dripping equipment can only be adjusted by changing the dripper and pressure, and the dripping frequency is low. In addition, it needs a large heat exchange surface area of ​​the paraffin cooling liquid, and the cycle efficiency is low. High consumption, resulting in large equipment volume, prone to cleaning dead ends, and high risk of cross-contamination

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