Hyperthermic interperitoneal chemotherapy device and method for establishing hyperthermic interperitoneal chemotherapy animal model
A hyperthermic perfusion, intraperitoneal technology, applied in the medical field, can solve the problems of inability to work and conduct research as expected, large volume differences, etc., and achieve the effects of convenient application, good tolerance and high feasibility
Inactive Publication Date: 2017-03-29
FUDAN UNIV SHANGHAI CANCER CENT
View PDF13 Cites 3 Cited by
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
However, when the peritoneal hyperthermic perfusion equipment is applied to animals, due to the large difference in size between humans and animals, direct application will inevitably result in failure to work normally and conduct research as expected, but there is no such device with high feasibility, good tolerance, and can significantly improve the therapeutic effect. , and a convenient and convenient intraperitoneal hyperthermic perfusion therapy system suitable for animal models
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View moreImage
Smart Image Click on the blue labels to locate them in the text.
Smart ImageViewing Examples
Examples
Experimental program
Comparison scheme
Effect test
Embodiment Construction
[0029] The specific embodiments provided by the present invention will be described in detail below with reference to the accompanying drawings.
[0030] The inventor of the present application has rich research experience in the field of clinical treatment and basic research of peritoneal hyperthermia, especially in the basic research of peritoneal hyperthermia that is rarely reported in the prior art, the inventor tried to establish an animal model of peritoneal hyperthermia therapy, And pay attention to observation, thinking and summary, and realize the following problems: (1) The animal model (such as tumor-bearing nude mice) is weak and not suitable for laparotomy. Accuracy; (2) The clinical peritoneal hyperthermia perfusion equipment adopts a closed loop, and the perfusate pumped by a filter membrane is filtered in the closed loop, but in fact the cancer cells and liquid in the metastases can be filtered out, but Some of the substances released by cancer cells and the tu...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More PUM
Login to View More Abstract
The invention relates to a hyperthermic interperitoneal chemotherapy device and a method for establishing a hyperthermic interperitoneal chemotherapy animal model. The hyperthermic interperitoneal chemotherapy device comprises a pumping in system, a pumping out system, and a thermocouple, wherein the pumping in system comprises a medicine storage bag, a first silicone tube, a first peristaltic pump, an infusion tube, a first puncture needle and a heat exchanging device. The pumping out system comprises a medicine recovery bag, a second silicon tube, a second peristaltic pump, a discharge pipe and a second puncture needle. The thermocouple is used for monitoring the temperature of infusion solution enterocoelia inlet and outlet. The hyperthermic interperitoneal chemotherapy device is suitable for establishing a hyperthermic interperitoneal chemotherapy animal model, which can reduce infection rate substantially, has good tolerance and high feasibility and can substantially increase treatment effect; the device has simple structure and is convenient to use and is suitable for scientific research.
Description
technical field [0001] The invention relates to the field of medicine, in particular to an abdominal cavity hyperthermia perfusion device applied to an animal model and a method for establishing an animal model for abdominal cavity hyperthermia perfusion therapy. Background technique [0002] Hyperthermic intraperitoneal perfusion therapy (HIPEC) is to fill the abdominal cavity with perfusate containing chemotherapeutic drugs, at a precise constant temperature and constant speed, and circulatory perfusion for a certain period of time. The synergistic effect of tumor and mechanical flushing effect can achieve the therapeutic effect of removing free cancer cells, subclinical lesions and small cancer nodules in the abdominal cavity, thereby preventing and treating colon cancer peritoneal metastasis. High-precision temperature control and high-precision control of perfusion speed are the technical keys of HIPEC. When the temperature is maintained at 42-43 °C, it has a synergisti...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More Application Information
Patent Timeline
Login to View More Patent Type & Authority Applications(China)
IPC IPC(8): A61M3/02A61F7/12
CPCA61F7/12A61M3/025A61M3/0258A61M2205/05A61M2205/127
Inventor 蔡国响刘建文李玥琪邱晟徐烨蔡三军
Owner FUDAN UNIV SHANGHAI CANCER CENT