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A magnetically driven liquid quantitative control device

A control device, magnetic drive technology, applied in laboratory utensils, laboratory containers, chemical instruments and methods, etc., can solve the problem of not being able to accurately and quantitatively extract or transport picoliters of liters of liquid, and achieve high accuracy The effect of high degree and accuracy

Active Publication Date: 2018-10-26
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, the above-mentioned operations are all based on the experience of the operator, and there is no device that can accurately and quantitatively extract or transport the liquid from picoliters to femtoliters

Method used

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  • A magnetically driven liquid quantitative control device
  • A magnetically driven liquid quantitative control device
  • A magnetically driven liquid quantitative control device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A magnetically driven liquid quantitative control device, such as figure 1 As shown, it consists of a capillary 1, a magnetic ball 2, a magnetic ball cabin 3, a magnet 4, a two-dimensional mobile platform and a controller; the capillary 1 is a fused silica capillary with an inert inner wall, and the inner diameter is 5 microns. The inlet end is the front port, and the other end is the tail port. The front port of the capillary is directly inserted into the sample solution to be extracted. The sample liquid is an acetonitrile solution containing trace hormones, and the tail port is inserted into the pure acetonitrile solution. The magnetic sphere chamber 3 is arranged close to the tail port of the capillary, and the maximum inner diameter is 320 microns. The magnetic ball 2 is placed in the capillary 1 as a piston, and is located between the front end of the capillary 1 and the magnetic ball compartment 3 . The magnet 4 is located outside the capillary 1 and keeps the m...

Embodiment 2

[0046] The device as described in Example 1 differs from Example 1 in that the capillary 1 is a quartz capillary whose inner wall is modified with polyethylene glycol, and the magnetic ball 2 is a synthetic ferric oxide whose outer surface wraps polyethylene glycol ball. The sample solution is a physiological solution containing protein. Before use, place the front port of capillary 1 in a physiological buffer solution, move the magnetic ball to the magnetic ball compartment, and press the physiological buffer into the capillary to fill it up. Then insert the end port of the capillary 1 into the physiological buffer solution, start the controller to move the magnetic ball between the front port of the capillary 1 and the magnetic ball compartment 3 . When in use, the front end of the capillary 1 is directly placed in the sample liquid.

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PUM

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Abstract

The invention provides a magnetically driven liquid quantitative control device, the device is composed of a capillary, a magnetic ball, a magnetic ball cabin, a magnet, a two-dimensional mobile platform and a controller; the magnetic ball is placed in the capillary, and the magnet Placed outside the capillary, the N and S poles of the magnet are placed opposite to each other outside the capillary, and the magnetic ball is located in the magnetic field of the magnet; the two-dimensional mobile platform is a fixed frame that can move along the axial direction of the capillary, and the magnet is fixed on the two-dimensional On the moving platform, the controller controls the two-dimensional moving platform and the magnet on the two-dimensional moving platform to move axially along the capillary, and then drives the magnetic ball to move axially in the capillary, and controls the displacement and speed of the magnetic ball in the capillary. The device can quantitatively control femtoliter to picoliter liquid, with high accuracy, and is suitable for precise analysis and operation; the surface of the magnetic ball is inert, and can be used to extract and transport biological fluids, which is very good in the field of cell biology research and micro-nano machining application prospects.

Description

technical field [0001] The invention relates to the field of liquid collection and transmission, in particular to a quantitative collection and quantitative delivery device for extremely micro-volume liquid. Background technique [0002] With the advancement of biotechnology and the development of micro-nano machining technology, scientists need to upgrade the skin (10 -12 L) Zhifei upgrade (10 -15 L) volume of liquid for quantitative manipulation. For example, biologists need to go deep into cells, collect substances in micron or even submicron regions, transfer them to analysis equipment, and analyze their molecular composition and content, so they need to quantitatively collect femtoliter liquids; in the process of micro-nano machining, Sometimes it is necessary to inject pico-upgrading or even femto-upgrading reagents into designated microregions. However, at present, the above-mentioned control is all based on the experience of the operator, and there is no device th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01L3/00
Inventor 关亚风段春凤田晓静
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI