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Glandular cystitis and bladder cancer diagnosing and distinguishing marker, and glandular cystitis and bladder cancer diagnosing reagent or kit

A technology for cystitis and bladder cancer, applied in the field of biomarkers, can solve the problems of cumbersome preoperative preparation and postoperative treatment, increasing physical and psychological pain of examiners, and inappropriate bladder examination.

Active Publication Date: 2017-03-29
嘉兴迈维代谢生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, cystoscopy has many contraindications, such as the urethra and bladder should not be checked in the acute inflammation stage, the bladder capacity is too small to be checked, and women who are menstruating or pregnant for more than 3 months should not be checked
Moreover, preoperative preparation and postoperative treatment are cumbersome
These increase the examiner's physical and psychological distress

Method used

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  • Glandular cystitis and bladder cancer diagnosing and distinguishing marker, and glandular cystitis and bladder cancer diagnosing reagent or kit
  • Glandular cystitis and bladder cancer diagnosing and distinguishing marker, and glandular cystitis and bladder cancer diagnosing reagent or kit

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1: Diagnosis and distinction between cystitis glandularis and bladder cancer based on circulating microRNA in peripheral blood

[0032] Part 1: Screening Phase

[0033] 1. Experimental materials and experimental methods

[0034] 1. Plasma samples: 23 cases of cystitis glandular research subjects, aged 45 to 55 years, with an average age of 51.3 years, 12 males and 11 females, 6 cases of chronic inflammatory type (3M / 3F), filtration 5 cases of blister edema type (3M / 2F), 5 cases of papilloma type (2M / 3F), and 7 cases of intestinal adenomatous type (4M / 3F); 21 cases of bladder cancer group, aged 43-54 years, The average age was 50.1 years, 12 males and 9 females, specifically bladder urothelial carcinoma (12M / 9F). All cases were newly diagnosed and had no history of drug treatment. There was no significant difference in the age of the subjects in each group, and all patients had normal heart, lung, liver, kidney and hematopoietic functions. The peripheral ven...

Embodiment 2

[0054] Example 2: Diagnosis and distinction between cystitis glandularis and bladder cancer based on plasma small molecule metabolites

[0055] Part 1: Screening Phase

[0056] 1. Experimental materials and experimental methods

[0057] 1. Plasma samples: 23 cases of cystitis glandular research subjects, aged 45 to 55 years, with an average age of 51.3 years, 12 males and 11 females, 6 cases of chronic inflammatory type (3M / 3F), filtration 5 cases of blister edema type (3M / 2F), 5 cases of papilloma type (2M / 3F), and 7 cases of intestinal adenomatous type (4M / 3F); 21 cases of bladder cancer group, aged 43-54 years, The average age was 50.1 years, 12 males and 9 females, specifically bladder urothelial carcinoma (12M / 9F). All cases were newly diagnosed and had no history of drug treatment. There was no significant difference in the age of the subjects in each group, and all patients had normal heart, lung, liver, kidney and hematopoietic functions. The peripheral venous bl...

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Abstract

The invention discloses a glandular cystitis and bladder cancer diagnosing and distinguishing marker, and a glandular cystitis and bladder cancer diagnosing reagent or kit. The biological marker comprises Tiglylcarnitine, arachidonic acid, lysophosphatidylcholine (18:2) and lysophosphatidylcholine (20:3). The AUC is 0.872 when combination of the Tiglylcarnitine, arachidonic acid, lysophosphatidylcholine (18:2) and lysophosphatidylcholine (20:3) is applied to diagnose and distinguish glandular cystitis and bladder cancer, so the combination has certain accuracy. The biological marker can be used for noninvasive diagnosis and distinguishing of the glandular cystitis and bladder cancer, overcomes shortages of cystoscope inspection, is hopeful to substitute biopsy, and can be used to form a diagnosing reagent or kit.

Description

technical field [0001] The invention relates to a biomarker, in particular to a marker for the diagnosis of cystitis glandularis and bladder cancer, a diagnostic reagent or a kit for non-invasive diagnosis of cystitis glandularis and bladder cancer. Background technique [0002] Cystitis glandularis is a hyperplastic lesion of the mucosa. In addition to epithelial cell nests, glands and small cysts, there are different degrees of plasma cell infiltration in the lamina propria [Reference: Tang Hao et al., Second Military Doctor Department of Urology, University Changhai Hospital, Cystitis glandularis and its diagnosis and treatment, Journal of Clinical Urology, 2008]. PantuckAJ found the correlation between monoclonal antibody expression in cystitis glandularis and bladder cancer by immunohistochemical methods, and confirmed that cystitis glandularis is a precancerous lesion of bladder cancer, and it is easy to be misdiagnosed as bladder cancer [Reference: Adenocarcinoma of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/48G01N30/02C12Q1/68
CPCC12Q1/6883C12Q2600/112C12Q2600/158C12Q2600/178G01N30/02G01N33/48G01N2800/34
Inventor 不公告发明人
Owner 嘉兴迈维代谢生物科技有限公司
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