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Artificial blood vessel in-vivo environment simulation apparatus

A technology of artificial blood vessels and simulation devices, applied in the field of biomedical research, can solve the problems of high cost, poor reproducibility, time-consuming and labor-intensive in vivo experiments, etc., and achieve the effect of improving energy efficiency

Pending Publication Date: 2017-04-26
NANTONG TEXTILE & SILK IND TECH RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Similarly, in terms of degradation performance, the researchers only performed static degradation on the artificial blood vessel for a period of time at simulated body temperature. The artificial blood vessel was not affected by any pulsating pressure, and whether the pulsating pressure would have a substantial impact on its degradation performance unaware
The traditional method of testing the compliance and degradation performance in vivo is to implant the artificial blood vessel into the animal body, and take out the sample after a period of time, and compare the measured late compliance and degradation performance with the initial performance value to achieve long-term observation. The purpose of compliance and degradation performance, but due to the physiological (including gender, size, age, etc.) differences of living animals, structural differences and the influence of environmental factors on the state of organisms, in vivo experiments are time-consuming, laborious, costly and poorly reproducible

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A long-term simulation environment test was carried out on the silk fibroin / poly-L-lactate caprolactone artificial blood vessel with an inner diameter of 3 mm and a length of 6 cm.

[0038] The specific test steps are as follows:

[0039] [1] Add two-thirds of water (12) to the body temperature simulation device (1), submerge the internal temperature control heating rod, turn on the power, turn on the constant temperature water bath oscillator (11), set the temperature to 37°C, Preheat for half an hour.

[0040] [2] Turn on the DC power supply (73) and the pressure display (72), put the pressure test device (7) in working condition, and connect the first and last ends of the flow guide silicone tube (2) connected to the peristaltic pump and the sample installation device Insert it into the water (12) in the body temperature simulation device (1), turn on the electronic peristaltic pump (4) to ensure that the system can circulate without water leakage, and the pressure ...

Embodiment 2

[0047] The long-term simulation environment simulation test was carried out on the silk fibroin / poly-L-lactide caprolactone artificial blood vessel with an inner diameter of 10mm and a length of 10cm.

[0048] The specific test steps are as follows:

[0049] [1] Add two-thirds of water (12) to the body temperature simulation device (1), submerge the internal temperature control heating rod, turn on the power, turn on the constant temperature water bath oscillator (11), set the temperature to 37°C, Preheat for half an hour.

[0050] [2] Turn on the DC power supply (73) and the pressure display (72), put the pressure test device (7) in working condition, and connect the first and last ends of the flow guide silicone tube (2) connected to the peristaltic pump and the sample installation device Insert it into the water (12) in the body temperature simulation device (1), turn on the electronic peristaltic pump (4) to ensure that the system can circulate without water leakage, and ...

Embodiment 3

[0057] A long-term simulation test was carried out on the silk fibroin / poly-L-lactate caprolactone artificial blood vessel with an inner diameter of 40mm and a length of 20cm.

[0058] The specific test steps are as follows:

[0059] [1] Add two-thirds of water (12) to the body temperature simulation device (1), submerge the internal temperature control heating rod, turn on the power, turn on the constant temperature water bath oscillator (11), set the temperature to 37°C, Preheat for half an hour.

[0060] [2] Turn on the DC power supply (73) and the pressure display (72), put the pressure test device (7) in working condition, and connect the first and last ends of the flow guide silicone tube (2) connected to the peristaltic pump and the sample installation device Insert it into the water (12) in the body temperature simulation device (1), turn on the electronic peristaltic pump (4) to ensure that the system can circulate without water leakage, and the pressure test device ...

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Abstract

The invention discloses an artificial blood vessel in-vivo environment simulation apparatus. The apparatus comprises a body temperature simulation device, a flow guiding silicone tube, a current limiting and pressure regulating valve, an electronic peristaltic pump, a sample mounting device, a sample connecting device and a pressure test device. The apparatus can really simulate the human body environment temperature, the blood vessel in-vitro liquid environment, the pulse pressure brought by continuous blood flow in the blood vessel and other real conditions, and the apparatus and a disclosed use method of the apparatus are used to provide conditions for assessment of the long-term mechanical performances and the degrading performance of the artificial blood vessel under in-vitro bionic conditions.

Description

technical field [0001] The invention belongs to the field of biomedical research, and in particular relates to an artificial blood vessel internal environment simulation device, which is used for testing and researching long-term dynamic compliance and degradation performance of artificial blood vessels with various calibers in vitro. Background technique [0002] Before the artificial blood vessel can be put into clinical use, it needs to go through strict tests and evaluations of various performances. Only when the artificial blood vessel meets all the standards can it be transplanted into the patient's body to replace the natural blood vessel or act as a vascular stent to promote natural angiogenesis. effect. The evaluation of artificial blood vessels is divided into two parts: in vitro and in vivo. Some of the in vitro evaluation indicators need to be tested in a simulated in vivo environment, such as compliance and degradation performance. [0003] The compliance of bl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/00
CPCG01N33/00G01N33/0078
Inventor 赵荟菁李向顺
Owner NANTONG TEXTILE & SILK IND TECH RES INST
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