Minoxidil molecularly imprinted polymer, preparation method of minoxidil molecularly imprinted polymer, minoxidil solid-phase extraction column and method for separating and purifying minoxidil
A technology of molecular imprinting and polymers, which is applied in separation methods, solid adsorbent liquid separation, and other chemical processes, can solve the problems of sample interference and complex operation of processing methods, and achieve the effects of reducing interference, improving purity, and facilitating implementation
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Embodiment 1
[0033] Example 1, the minoxidil molecularly imprinted polymer is obtained according to the following preparation method:
[0034] The first step is to reflux clean the spherical silica gel with inorganic acid for 18 hours to 24 hours to obtain activated silica gel, then wash the activated silica gel with water until it is neutral, and then dry it to constant weight. Among them, the inorganic acid and spherical silica gel The mass ratio is 5:1 to 10:1, and the spherical silica gel is 300 mesh to 400 mesh spherical silica gel;
[0035] The second step is to disperse 1 part of activated silica gel in 10 to 25 parts of organic reagent I in parts by weight to obtain a silica gel dispersion solution, and then add 3-aminopropyltriethoxysilane to spherical silica gel Carry out silanization, the reaction condition of silanization is 110°C to 150°C under nitrogen atmosphere for 18 hours to 24 hours, the mass ratio of spherical silica gel to 3-aminopropyltriethoxysilane is 1:1 to 1:1.5, ...
Embodiment 2
[0041] Example 2, the minoxidil molecularly imprinted polymer is obtained according to the following preparation method: first, the spherical silica gel is first reflux cleaned with inorganic acid for 18 hours or 24 hours to obtain the activated silica gel, and then the activated silica gel is purified with water. The silica gel is washed to neutral and then dried to constant weight, wherein the mass ratio of inorganic acid to spherical silica gel is 5:1 or 10:1, and the spherical silica gel is 300 mesh or 400 mesh spherical silica gel;
[0042] The second step is to disperse 1 part of activated silica gel in 10 parts or 25 parts of organic reagent I in parts by weight to obtain a silica gel dispersion solution, and then add 3-aminopropyltriethoxysilane to spherical silica gel For silanization, the reaction conditions for silanization are 110°C or 150°C under nitrogen atmosphere for 18 hours or 24 hours, the mass ratio of spherical silica gel to 3-aminopropyltriethoxysilane is ...
Embodiment 3
[0048] Example 3, as an optimization of the above examples, the polymerization in the fifth step adopts thermal initiation polymerization, the temperature of thermal initiation polymerization is 60°C to 90°C, and the polymerization reaction time is 6 hours to 48 hours; or, in the fifth step The polymerization adopts photoinitiated polymerization, and the conditions of photoinitiated polymerization are: the power of the high-pressure mercury lamp is 125W or 150W, and the polymerization time is 0.5 hours to 48 hours.
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