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Ezetimibe dispersing tablet, and preparation method thereof

A technology of ezetimibe and dispersible tablets, applied in the field of medicine, can solve the problems of dissolution rate affecting bioavailability and curative effect, and achieve the effects of improving disintegration and dissolution, good taste and improving dispersibility

Inactive Publication Date: 2017-05-24
谭惠娟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Since the molecular polarity of ezetimibe is relatively small, it is almost insoluble in water, and the dissolution rate will affect its bioavailability, thereby affecting its efficacy

Method used

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  • Ezetimibe dispersing tablet, and preparation method thereof
  • Ezetimibe dispersing tablet, and preparation method thereof
  • Ezetimibe dispersing tablet, and preparation method thereof

Examples

Experimental program
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Embodiment Construction

[0020] Preparation Example

[0021] The preparation method of ezetimibe dispersible tablet of the present invention comprises the following steps:

[0022] (1). Dissolve ezetimibe in 10 times the weight of ethanol according to Table 1. After absorbing the ezetimibe-containing ethanol solution with a filler, evaporate the ethanol;

[0023] (2). Mix the filler adsorbed with ezetimibe evenly with disintegrating agent, binder, lubricant and essence, and directly compress the tablet to obtain 100 tablets for each embodiment.

[0024]

[0025]

[0026]

[0027] The filler can be one of the pharmaceutically acceptable fillers suitable for powder compression or used in combination. The binder may be one of the pharmaceutically acceptable binders suitable for powder compression.

[0028] Dispersion uniformity example

[0029] Carry out according to [dispersion uniformity] in Chinese Pharmacopoeia 2010 edition appendix IA tablet.

[0030] Take the tablets prepared in Exam...

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PUM

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Abstract

The invention discloses an ezetimibe dispersing tablet, and a preparation method thereof, and belongs to the field of medicine. The ezetimibe dispersing tablet is composed of, by weight, 0.5 to 1.5% of ezetimibe, 10 to 20% of a disintegrating agent, 70 to 80% of a filler, 5 to 10% of an adhesive, 0.5 to 2% of a lubricant, and 0.01 to 0.05% of an essence. The preparation method comprises following steps: 1, ezetimibe is dissolved in ethanol at a formula ratio, the obtained ethanol solution containing formula ratio is subjected to absorption by the filler so as to remove ethanol via volatilization; 2, the filler containing ezetimibe is uniformly mixed with the disintegrating agent, the adhesive, the lubricant, and the essence, and an obtained mixed material is subjected to tabletting directly so as to obtain finished products. Rapid disintegration of the obtained ezetimibe dispersing tablet can be realized, dissolution rate is relatively high, taste after dissolution is excellent, and the ezetimibe dispersing tablet can be accepted by consumers easily.

Description

technical field [0001] The present invention relates to the field of medicine. Background technique [0002] With the improvement of living standards, people's eating habits are gradually changing: the intake of meat is increasing, while the intake of vegetables is relatively decreasing. At the same time, more and more food additives are used in people's daily food, and some unscrupulous traders ignore the limit of food additives in pursuit of better taste. Such eating habits and food are slowly eroding people's health. There are more and more people suffering from diseases of affluence represented by high blood pressure and high blood fat. [0003] Ezetimibe is a drug for treating hypercholesterolemia, which was first launched in Germany in November 2002 under the trade name EZETROL. The chemical name is (3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxybenzene Base)-2-azetidinone, the structural formula is as follows. Its mechanism of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/397A61K47/20A61K47/26A61P3/06
CPCA61K9/20A61K31/397
Inventor 谭惠娟
Owner 谭惠娟
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