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A cell temperature measurement system

A temperature measurement and cell technology, applied in thermometers, heat measurement, measurement devices, etc., can solve problems such as non-invasive measurement, and achieve the effect of improving work efficiency

Active Publication Date: 2019-03-26
黑龙江省工研院资产经营管理有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, fluorescent nano temperature sensors based on quantum dots require cells to swallow quantum dots inside to measure temperature, which cannot be truly non-invasive.

Method used

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  • A cell temperature measurement system
  • A cell temperature measurement system

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Experimental program
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Embodiment Construction

[0026] combine figure 1 Describe this embodiment, a cell temperature measurement system described in this embodiment, including a quantum dot film temperature sensor, an excitation system, a camera system, and a processing system;

[0027] A quantum dot thin film temperature sensor for sensing the temperature of multiple cells using a quantum dot thin film;

[0028] The excitation system is used to generate a modulated laser signal to induce the quantum dot film in the quantum dot film temperature sensor to emit light;

[0029] A camera system for acquiring a sequence of images of quantum dot thin films emitting light;

[0030] The processing system is used to control the work of the excitation system and the camera system, and is also used to process the acquired image sequence, obtain the amplitude and phase of the image sequence, and determine the temperature of each cell according to the corresponding relationship between the amplitude and phase and temperature.

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Abstract

The invention provides a non-invasive cell temperature measurement system for simultaneously measuring a plurality of cells by using phase-locked carrier imaging technology and quantum dot films, belonging to the field of temperature measurement of micro-nano-sized targets. Including: a quantum dot thin film temperature sensor, used to sense the temperature of multiple cells by using a quantum dot thin film; an excitation system, used to generate a modulated laser signal to induce the quantum dot thin film in the quantum dot thin film temperature sensor to emit light; a camera system for Acquire the image sequence of quantum dot thin film luminescence; the processing system is used to control the work of the excitation system and the camera system, and is also used to process the acquired image sequence to obtain the amplitude and phase of the image sequence, according to the relationship between the amplitude and phase and temperature Correspondence, determine the temperature of each cell.

Description

technical field [0001] The invention relates to a temperature measurement system, in particular to a cell temperature measurement system, which belongs to the field of temperature measurement of micro-nano-sized objects. Background technique [0002] In the biochemical reaction of cells, temperature is one of the important physical parameters, which affects a series of cellular activities from protein synthesis, cell division, gene expression and energy metabolism. Temperature measurement at the cellular level is of great significance, but also a difficult problem in the field of biomedicine. Nowadays, with the development of electronic technology, optical technology and nanotechnology, it has become possible to measure the temperature of micro-nano-sized objects such as cells. Nano temperature sensors can be divided into three categories: electronic nano temperature sensors based on thermocouples, mechanical nano temperature sensors and optical nano temperature sensors. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01K1/02C12M1/34
CPCG01K1/026
Inventor 张昱
Owner 黑龙江省工研院资产经营管理有限公司