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A preparation method of biofunctional coating on the surface of pure magnesium with low corrosion rate

It is a technology of biological functionalization and corrosion rate, which can be used in coatings, metal material coating processes, tissue regeneration and other directions. The effect of convenience and low preparation cost

Active Publication Date: 2019-05-17
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these existing coating technologies have problems such as complicated operation, strict requirements, unstable structure after modification, and easy loss of bioactive molecules.

Method used

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  • A preparation method of biofunctional coating on the surface of pure magnesium with low corrosion rate
  • A preparation method of biofunctional coating on the surface of pure magnesium with low corrosion rate
  • A preparation method of biofunctional coating on the surface of pure magnesium with low corrosion rate

Examples

Experimental program
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Effect test

Embodiment 1

[0022] A method for preparing a biofunctional coating on the surface of pure magnesium with low corrosion rate, the steps are:

[0023] A, the NaOH solution of 1mol / L is joined in the aminotrimethylene phosphonic acid solution that concentration is 2.5mmol / L, obtains the modified solution that pH value is 7;

[0024] B, soaking pure magnesium in a NaOH solution with a temperature of 60°C and a concentration of 3mol / L for 24 hours to obtain alkali-activated pure magnesium;

[0025] C. Soak the pure magnesium after alkali activation in the modified solution of step A, heat up to 60°C, and keep it warm for 12 hours; obtain pure magnesium with an aminotrimethylene phosphonic acid coating on the surface;

[0026] D, put the pure magnesium with aminotrimethylene phosphonic acid coating on the surface prepared in step C into a magnesium sulfate solution with a concentration of 0.5mol / L and soak for 2 hours to obtain a layer of corrosion rate on the surface of pure magnesium Biofunct...

Embodiment 2

[0030] A method for preparing a biofunctional coating on the surface of pure magnesium with low corrosion rate, the steps are:

[0031] A, the NaOH solution of 1mol / L is joined in the aminotrimethylene phosphonic acid solution that concentration is 5mmol / L, obtains the modified solution that pH is 9;

[0032] B, soaking pure magnesium in a NaOH solution with a temperature of 65°C and a concentration of 3mol / L for 18 hours to obtain alkali-activated pure magnesium;

[0033] C. Soak the pure magnesium after alkali activation in the modified solution, heat up to 80° C., and keep it warm for 17 hours; obtain pure magnesium with an aminotrimethylene phosphonic acid coating on the surface;

[0034] D, put the pure magnesium with aminotrimethylene phosphonic acid coating on the surface prepared in step C into a magnesium sulfate solution with a concentration of 0.5mol / L and soak for 1.5 hours, and obtain a layer of corrosion rate on the surface of pure magnesium Biofunctionalized co...

Embodiment 3

[0038] A method for preparing a biofunctional coating on the surface of pure magnesium with low corrosion rate, the steps are:

[0039] A, the NaOH solution of 1mol / L is joined in the aminotrimethylene phosphonic acid solution that concentration is 10mmol / L, obtains the modified solution that pH is 5;

[0040] B, soaking pure magnesium in a NaOH solution with a temperature of 55°C and a concentration of 3mol / L for 12 hours to obtain alkali-activated pure magnesium;

[0041] C. Soak the pure magnesium after alkali activation in the modified solution, heat up to 50° C., and keep it warm for 24 hours; obtain pure magnesium with an aminotrimethylene phosphonic acid coating on the surface;

[0042] D, put the pure magnesium with aminotrimethylene phosphonic acid coating on the surface prepared in step C into a magnesium sulfate solution with a concentration of 0.5mol / L and soak for 1 hour to obtain a layer of corrosion rate on the surface of pure magnesium Biofunctionalized coatin...

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Abstract

The invention discloses a preparation method of a biofunctional coating on the surface of pure magnesium with a low corrosion rate. The steps are: A. Adding 1mol / L NaOH solution to aminotrimethylene phosphonic acid with a concentration of 2.5-10mmol / L solution, obtain a modified solution with a pH value of 5-9; B, soak pure magnesium in the NaOH solution of 1-6mol / L for 12-24 hours to obtain alkali-activated pure magnesium; C, alkali-activated Soak pure magnesium in the modified solution, heat up to 50-80°C, and keep warm for 12-24 hours; obtain pure magnesium with amino trimethylene phosphonic acid coating on the surface; D, the surface obtained in step C has amino Pure magnesium coated with trimethylene phosphonic acid is soaked in a magnesium sulfate solution with a concentration of 0.5mol / L for 1-2 hours, and a layer of biofunctional coating on the surface of pure magnesium with low corrosion rate is obtained on the surface of pure magnesium. Floor. The biofunctional coating prepared by the method has good biocompatibility and low corrosion rate.

Description

technical field [0001] The invention relates to a preparation method of a biofunctional coating on the surface of pure magnesium. Background technique [0002] Magnesium is highly corrodible and degradable in vivo, and the magnesium ions generated by degradation can be absorbed by human tissues or excreted through metabolism. At the same time, magnesium ions can participate in physiological activities as cofactors related to energy metabolism, and the elastic modulus of magnesium is close to that of human bones, which has good mechanical compatibility. Therefore, magnesium has been widely used as a biological implant material in the field of bone tissue repair, and has a good application prospect in the application of vascular stent materials. However, due to the high chemical activity of magnesium, when it is implanted into the human body as an implant material, it is easily corroded by the surrounding physiological environment, causing it to lose its mechanical properties...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C23C22/08C23C22/60C23C22/68A61L27/04A61L27/28A61L27/50
CPCA61L27/047A61L27/28A61L27/50A61L2430/02C23C22/08C23C22/60C23C22/68
Inventor 万国江屈艾蒲世民张文泰李薇唐欣刘启军黄楠
Owner SOUTHWEST JIAOTONG UNIV
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