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Membrane for protecting intraocular tissues and the protection methods used thereof

A film and transparent film technology, applied in tissue regeneration, application, ophthalmic surgery, etc., can solve the problems of insufficient protection and compartmentalization, difficult to determine the location, unable to form a barrier plane, etc. The effect of fitting, improving elasticity and curvature

Active Publication Date: 2017-06-27
IND TECH RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, taking cataract surgery as an example, the OVD on the market still has the following operational risks during the operation: (1) insufficient protection and compartmentation; (2) it is difficult to determine its location during and after the operation, and whether it is still remain in the eye; (3) easy to be lost from the wound or taken away by drainage devices during the operation; and (4) unable to form a complete barrier plane

Method used

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  • Membrane for protecting intraocular tissues and the protection methods used thereof
  • Membrane for protecting intraocular tissues and the protection methods used thereof
  • Membrane for protecting intraocular tissues and the protection methods used thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] First, 0.5 g of collagen (fibrous, about 15 mm in length) was added to the reaction bottle, and 100 mL of an aqueous solution with a pH of less than 5 was added to the reaction bottle to disperse the collagen. Next, after stirring until the collagen is completely dispersed in water, the resulting solution is poured into a mold, and placed at room temperature for air-drying. Then, the resulting film can be directly cross-linked and cut into a circle with a diameter of 6-16mm to obtain the film (I); on the other hand, the film can absorb water and cover it on a mold to make it dry and have a arc-shaped curved surface, that is, an arc-shaped curved surface with a radius of curvature of 6-8 mm, and then cross-link the film with the arc-shaped curved surface and cut it into a circle with a diameter of 6-16 mm to obtain a film (I'); The cross-linking reaction was carried out by placing the film in a chamber with saturated vapor of formaldehyde gas for one hour.

Embodiment 2

[0050] First, 0.5 g of collagen (fibrous, about 15 mm in length) was added to the reaction bottle, and 100 mL of an aqueous solution with a pH of less than 5 was added to the reaction bottle to disperse the collagen. Next, after stirring until the collagen is completely dispersed in water, the resulting solution is poured into a mold, and placed at room temperature for air-drying. Then, one can directly cross-link the obtained film and cut it into a circle with a diameter of 6-16mm to obtain the film (II); another can cover the film on a mold after absorbing water, so that it has a arc-shaped surface, that is, an arc-shaped surface with a radius of curvature of 6-8mm, and then cross-link the film with the arc-shaped surface and cut it into a circle with a diameter of 6-16mm to obtain a film (II'); The contact method is to place the film in a cavity and irradiate ultraviolet light for one hour to carry out the crosslinking reaction, wherein the ultraviolet light has a wavelengt...

Embodiment 3

[0052] First, 0.5 g of polyvinyl alcohol (polyvinyl alcohol, PVA; molecular weight about 30,000-50,000) was added to the reaction flask, and 100 mL of pure water was added. After heating and stirring until the polyvinyl alcohol is completely dispersed, an aqueous solution of polyvinyl alcohol is obtained. Next, the aqueous solution of polyvinyl alcohol was titrated with aqueous hydrochloric acid (concentration: 6N), so that the pH of the aqueous solution of polyvinyl alcohol was less than about 3. Next, 0.5 g of collagen (in the form of fibrous fibers with a length of about 15 mm) was added into the reaction bottle, and stirred until the collagen was completely dispersed. Then, the obtained solution was poured into a mold, and placed at room temperature for air-drying. Then, one can directly cross-link the obtained film and cut it into a circle with a diameter of 6-16mm to obtain the film (III); another can cover the film on a mold after absorbing water, so that it has a arc...

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Abstract

According to embodiments, a membrane with a flat or curved surface is provided for protection of intraocular tissues. The membrane can be used to cover the cornea for protecting corneal endothelial cells, to cover the anterior and posterior surface of the iris, or to cover the surface of the posterior capsule for separating the intraocular tissues. The membrane has a layered structure, which is composed of a collagen and a hydrophilic biopolymer or an organic polymer material. In particular, the membrane has high transparency and high water retention in a wet state.

Description

technical field [0001] The invention relates to a film for protecting the flat or arc-shaped surfaces of intraocular tissues, especially a film with high water retention and high transparency in a state of absorbing moisture, which is used for protecting corneal endothelial cells and isolating intraocular tissues. Background technique [0002] In various intraocular surgeries, protecting corneal endothelial cells from being damaged by the surgical procedure is a key factor affecting the success of the surgery. In particular, some intraocular operations need to block the improper displacement of the air in the anterior and posterior chambers of the iris during the operation, so as to avoid improper communication of the air in the anterior and posterior chambers during the operation, which will affect the success rate of the operation. And, it is still necessary to prevent the improper displacement of the vitreous body during the operation, so as to avoid the residual anterior...

Claims

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Application Information

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IPC IPC(8): A61F9/00A61L31/04A61L31/14
CPCA61F9/0017A61L31/041A61L31/14C08L5/08C08L71/02C08L29/04C08L39/06A61F9/00745A61L27/16A61L27/18A61L27/24A61L2430/16A61B90/04A61B2090/0472A61B2090/08021A61P27/02A61P41/00A61L31/044A61L31/048A61L31/06A61L31/129A61B2090/0427A61B2090/0445
Inventor 刘育秉王琇莹徐新怡陈伟励黄金宗沈欣欣
Owner IND TECH RES INST
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