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Supermolecular bactericide as well as preparation method and sterilization method thereof

A supramolecular and fungicide technology, applied in the field of supramolecular chemistry, can solve the problems affecting the activity and effect of fungicides, and achieve the effect of delaying drug-resistant pathogens and avoiding long-term coexistence

Active Publication Date: 2017-06-30
INST OF CHEM CHINESE ACAD OF SCI
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Problems solved by technology

However, the emergence of drug resistance greatly affects the activity and effect of fungicides.

Method used

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  • Supermolecular bactericide as well as preparation method and sterilization method thereof
  • Supermolecular bactericide as well as preparation method and sterilization method thereof
  • Supermolecular bactericide as well as preparation method and sterilization method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-4 and comparative example 1-4

[0057] (1) Preparation of fungicides

[0058] Weigh the cationic surfactant represented by the formula (I) and the cucurbit [n] urea represented by the formula (II), and completely dissolve them in 5 mL of ultrapure water at 40° C. to prepare a fungicide with a concentration of 2 mM.

[0059] Table 1 shows the material types, concentrations, material combination ratios, combination constants and obtained bactericide structures used in the fungicide systems of Preparation Examples 1-4 and Comparative Examples 1-4. Wherein, the bactericide that embodiment 1-4 obtains is supramolecular bactericide provided by the present invention, does not add cucurbit [n] urea in comparative example 1-4, and the bactericide that obtains is the cationic surface shown in formula (I) active agent.

[0060] Table 1

[0061]

[0062] (2) The inhibitory effect of fungicides on pathogenic bacteria

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Abstract

The invention relates to the field of supramolecular chemistry, and discloses a supermolecular bactericide as well as a preparation method and sterilization method thereof. The supermolecular bactericide contains a cation type surfactant as shown in a formula (I) and a bottle gourd [n] urease as shown in a formula (II), wherein R1 is C8-C18 alkyl, and is preferably C12 alkyl or C16 alkyl; R2 is C1-C3 alkyl or C6-C8 aryl groups, and preferably methyl or benzyl; n is 7 or 8, and is preferably 7; X- is Cl- or Br-. The preparation method of the supermolecular bactericide comprises the following step of dissolving the cation type surfactant as shown in the formula (I) and the bottle gourd [n] urease as shown in the formula (II) in water. The sterilization method comprises the following step of applying the supermolecular bactericide and amantadine hydrochloride onto objects to be sterilized. The sterilization activity of the supermolecular bactericide provided by the invention is intelligently controllable, and the drug tolerance problem of pathogenic bacteria can be effectively solved.

Description

technical field [0001] The invention relates to the field of supramolecular chemistry, in particular to a supramolecular bactericide, a preparation method and a bactericidal method thereof. Background technique [0002] Since Domagk G discovered that quaternary ammonium salts containing long-chain alkyl groups have strong bactericidal properties more than half a century ago, the synthesis of cationic active bactericides has been one of the more active areas of bactericide research, and has the advantages of fast bactericidal speed, It has the advantages of strong ability to kill and inhibit a variety of microorganisms, low toxicity, good biodegradability, and good solubility in water. However, the emergence of drug resistance greatly affects the activity and effect of fungicides. [0003] Drug resistance, also known as drug resistance, refers to the tolerance of microorganisms, parasites, and tumor cells to the effects of chemotherapy drugs. Once drug resistance occurs, the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N47/38A01N33/12A01P1/00A01P3/00
Inventor 王树白昊天吕凤婷刘礼兵
Owner INST OF CHEM CHINESE ACAD OF SCI
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