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Water-soluble propolis and preparation method of same

A technology of water-soluble propolis and propolis, which is applied in the direction of pharmaceutical formulations, cosmetic preparations, dressing preparations, etc., can solve the problems of easy precipitation of propolis, and achieve the effect of no irritating smell, wide audience and good taste

Inactive Publication Date: 2017-07-14
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The invention patent application with the publication number CN1460512A discloses a water-soluble propolis liquid and its preparation method. The patent uses polyethylene glycol to increase the solubility of propolis, but as the proportion of water increases, propolis is easy to precipitate

Method used

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  • Water-soluble propolis and preparation method of same
  • Water-soluble propolis and preparation method of same
  • Water-soluble propolis and preparation method of same

Examples

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Effect test

Embodiment 1

[0038] Embodiment 1: the preparation of water-soluble propolis of the present invention

[0039] The implementation steps of this embodiment are as follows:

[0040] (1) Add 95% ethanol aqueous solution (g / ml) with a volume ratio of 1:3 to the propolis raw material, ultrasonically extract, filter, remove insoluble matter, repeat extraction of the residue three times, and combine the filtrates to obtain propolis extract R1.

[0041] (2) Add polyoxyethylene ether hydrogenated castor oil to R1 at a mass ratio of 1:3 to propolis, stir to dissolve it completely, and then recover ethanol by rotary evaporation until the liquid has no alcohol smell to obtain R2.

[0042] (3) Put R2 in hot water for warm bath, add propylene glycol according to the mass ratio of propolis to 1:1, stir well to completely dissolve propolis. The filtrate was cooled to room temperature, allowed to stand, and filtered to obtain the propolis aqueous solution M.

[0043] (4) Dry and evaporate the water to obt...

Embodiment 2

[0068] Embodiment 2: the preparation of water-soluble propolis of the present invention

[0069] The implementation steps of this embodiment are as follows:

[0070] (1) Add 60% ethanol aqueous solution (g / ml) with a volume ratio of 1:8 to the propolis raw material, ultrasonically extract, filter, remove insoluble matter, repeat extraction of the residue three times, and combine the filtrates to obtain propolis extract R1.

[0071] (2) Add polyoxyethylene ether hydrogenated castor oil to R1 at a mass ratio of 1:0.5 to propolis, stir to dissolve it completely, and then recover ethanol by rotary evaporation until the liquid has no alcohol smell to obtain R2.

[0072] (3) Put R2 in hot water for warm bath, add propylene glycol according to the mass ratio of propolis to 1:2, stir well to completely dissolve propolis. The filtrate was cooled to room temperature, allowed to stand, and filtered to obtain the propolis aqueous solution M.

[0073] (4) Dry and evaporate the water to o...

Embodiment 3

[0098] Embodiment 3: the preparation of water-soluble propolis of the present invention

[0099] The implementation steps of this embodiment are as follows:

[0100] (1) Add 75% ethanol aqueous solution (g / ml) with a volume ratio of 1:5 to the propolis raw material, ultrasonically extract, filter, remove insoluble matter, repeat extraction of the residue three times, and combine the filtrates to obtain propolis extract R1.

[0101] (2) Add polyoxyethylene ether hydrogenated castor oil to R1 at a mass ratio of 1:1.5 to propolis, stir to dissolve it completely, and then recover ethanol by rotary evaporation until the liquid has no alcohol smell to obtain R2.

[0102] (3) Place R2 in hot water for warm bath, add propylene glycol according to the mass ratio of propolis to 1:5, stir well to completely dissolve propolis. The filtrate was cooled to room temperature, allowed to stand, and filtered to obtain the propolis aqueous solution M.

[0103] (4) Dry and evaporate the water to...

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Abstract

The invention provides a preparation method of water-soluble propolis. The preparation method includes the steps of: performing ultrasonic extraction to a propolis raw material with an ethanol water solution, adding a solubilizer, stirring and dissolving the raw material extract, recovering the ethanol until the liquid has no alcohol-like smell; and adding a cosolvent, stirring the liquid for dissolution, and filtering and drying the liquid to evaporate water off to prepare the water-soluble propolis. The method solves a defect of low water solubility of the propolis. The water-soluble propolis has no alcohol-like smell and odors, is free of loss on original active components in the propolis, and can be dissolved with water at any ratio. Compared with water-soluble propolis in the prior art, the water-soluble propolis is high in total flavones content, is free of ethanol, has no irritation effect and irritation smell, has good taste and has more target audiences, and can be applied to the fields of cosmetics, medicines, health care foods, etc.

Description

technical field [0001] The invention belongs to the field of preparation methods of bee products, and relates to a water-soluble propolis and a preparation method thereof. Background technique [0002] Propolis is a fragrant substance that bees collect plant resin and mix it with beeswax and other secretions. Propolis has a wide range of pharmacological activities, such as antibacterial, antioxidative, antiviral, anti-inflammatory, hepatoprotective and anticancer. As a functional ingredient, propolis has been widely used in food, medicine and health care products industries. At present, because propolis is alcohol-soluble, the application of propolis in food and medicine fields is limited. [0003] The water solubility of propolis is very poor. When using propolis, organic solvents and emulsifiers are mainly used to prepare propolis solutions, such as ethanol, polyethylene glycol, etc., or emulsified by Tween, soybean lecithin, lecithin, etc. Propolis ethanol aqueous solu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/644A61K8/98A23L21/20
CPCA61K35/644A23V2002/00A61K8/988A23V2200/14
Inventor 张翠平胡福良
Owner ZHEJIANG UNIV
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