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Drying method of fosfomycin calcium

A technology of calcium fosfomycin and drying method, which is applied in the directions of drying solid materials, drying solid materials without heating, and promoting the preliminary treatment of drying of solid materials, etc., and can solve the problems of large agglomerates and solids.

Active Publication Date: 2017-07-14
千辉药业(安徽)有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This preparation method adopts conventional drying method, and the shortcoming that it exists is: the agglomerate solid that makes is bigger

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment one: a kind of drying method of fosfomycin calcium

[0021] Use the wet product of fosfomycin calcium monohydrate as raw material, with a water content of 38%, put in 300kg of the wet product, first carry out coarse grinding, and put it into the dryer after passing through a Φ3.5mm sieve.

[0022] Dry for 30 minutes without rotation and without heating, and the vacuum degree is controlled at 20-30Kpa.

[0023] Enter step I drying, conditions (temperature 45±5°C; vacuum degree 20-30KPa; number of rotations: interval rotation; rotation time: 1 / 4 rotation; interval time: 30min; drying time: 16h).

[0024] Enter stepⅡdrying, conditions (temperature 60±5℃; rotation speed: 3rpm / min; vacuum degree: below 30KPa; drying time: 8~16h) goal: to make the product form fine clumps (size About Φ2~5cm).

[0025] Enter stepⅢ drying, conditions (temperature 60±5°C; rotation speed: 3rpm / min; vacuum degree: below 5KPa; drying time: above 8h), dry until the moisture value is 8.7...

Embodiment 2

[0027] Embodiment two: a kind of drying method of fosfomycin calcium

[0028] A method for drying fosfomycin calcium, comprising the following steps:

[0029] The first step: pulverize the wet product of fosfomycin calcium monohydrate;

[0030] The second step: put the pulverized fosfomycin calcium monohydrate wet product into the double cone dryer, and then control the vacuum degree in the double cone dryer to be 20 ~ 30Kpa;

[0031] The third step: control the vacuum degree in the double cone dryer to 20~30Kpa, the temperature is 45°C, and the double cone dryer is rotated at intervals;

[0032] Step 4: Control the vacuum degree in the double-cone dryer to be less than or equal to 30Kpa, the temperature is 45°C, and the drying time is 8-16 hours, so that fosfomycin calcium forms agglomerates with a diameter of 2-5cm;

[0033] Step 5: Control the vacuum degree in the double-cone dryer to be less than or equal to 5Kpa, the temperature is 60°C, and the drying time is greater t...

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PUM

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Abstract

A drying method of fosfomycin calcium comprises the following steps: step 1, crushing a fosfomycin calcium monohydrate wet product; step 2, feeding the crushed fosfomycin calcium monohydrate wet product into a double-cone dryer, and then controlling a vacuum degree in the double-cone dryer to be 20-30Kpa; step 3, controlling the vacuum degree in the double-cone dryer to be 20-30Kpa and temperature to be 40-50DEG C, enabling the double-cone dryer to rotate at intervals, and carrying out drying for 16h; step 4, controlling the vacuum degree in the double-cone dryer to be smaller than or equal to 30Kpa, temperature to be 55-65DEG C and drying time to be 8-16h so as to enable fosfomycin calcium crystals to form lumps with 2-5cm diameters; and step 5, controlling the vacuum degree in the double-cone dryer to be smaller than or equal to 5Kpa, temperature to be 55-65DEG C and drying time to be longer than or equal to 8h so as to enable the water content of the dried fosfomycin calcium crystals to be 8.7-12.0%. In the invention, the double-cone dryer is used for drying, and spinning extrusion is carried out on the fosfomycin calcium crystals in the drying process so as to obtain fine lump solids.

Description

technical field [0001] The invention belongs to the technical field of pharmacy and relates to a drying method of fosfomycin calcium. Background technique [0002] Fosfomycin is a broad-spectrum antibiotic. At present, there are four main varieties of fosfomycin, namely fosfomycin sodium salt, fosfomycin calcium salt, fosfomycin tromethamine salt, and fosfomycin benzylamine salt. The molecular structure of fosfomycin is similar to that of phosphoenolpyruvate, which can compete with the same transferase, hindering the synthesis of bacterial cell walls and leading to bacterial death. Mainly used for Gram-negative and positive bacterial infections. The product was discovered in Streptococcus in Spanish soil by Merck of the United States and CEPA in Spain in 1967; it was first put into industrial production in Spain in 1975, and then Italy and Germany also started industrial production. In 1980, Meiji's products were launched in Japan. Fosfomycin has strong antibacterial acti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): F26B1/00F26B5/04F26B25/22
CPCF26B1/005F26B5/04F26B25/22
Inventor 袁勇毛杰新川关井
Owner 千辉药业(安徽)有限责任公司
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