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Application of rhizoma chuanxiong essential oil in preparation of medicine for treating degenerative osteoarthropathy

A technology for osteoarthritis and Rhizoma Chuanxiong essential oil, applied in the field of application of Rhizoma Chuanxiong essential oil in the preparation of drugs for the treatment of degenerative osteoarthritis, can solve the problems of easy recurrence and large human body damage, and achieve good curative effect

Inactive Publication Date: 2017-07-25
四川九渊医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Degenerative osteoarthropathy currently has no particularly effective drugs for treatment, mainly through physical therapy to slow down the course of the disease; medication is mainly analgesic and anti-inflammatory, temporarily relieving the patient's pain; when the condition is very serious, surgery can be performed, but it will cause damage to the human body Very large and easy to relapse

Method used

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  • Application of rhizoma chuanxiong essential oil in preparation of medicine for treating degenerative osteoarthropathy
  • Application of rhizoma chuanxiong essential oil in preparation of medicine for treating degenerative osteoarthropathy
  • Application of rhizoma chuanxiong essential oil in preparation of medicine for treating degenerative osteoarthropathy

Examples

Experimental program
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Effect test

Embodiment 1

[0030] The initial essential oil of Chuanxiong was obtained through the following steps: crush 1Kg of Chuanxiong with a particle size of 5 mm, then mix it with 1Kg of deionized water, and wet the 1Kg of Chuanxiong for 13 hours. Continuously pass the water vapor at 150°C slowly through the wet Rhizoma Chuanxiong, and then condense the mixed steam passing through the wet Rhizoma Chuanxiong to obtain an oil-water mixture, and use a separatory funnel to separate the oil from water to obtain the essential oil of Rhizoma Chuanxiong. Since the components of the Chuanxiong essential oil extracted by the above method cannot be consistent with the precise values ​​required by the experimenter, pure ligustilide, pure cnidactone A and pure neocnilide were used in the examples. To adjust the extracted Chuanxiong essential oil, the adjusted Chuanxiong essential oil includes 10% ligustilide, 8% chuanxionglide A and 9% cnidactone, and the remaining components are other esters.

Embodiment 2

[0032] The initial essential oil of Chuanxiong was obtained through the following steps: crush 0.9Kg of Chuanxiong with a particle size of 6 mm, then mix it with 0.45Kg of deionized water, and wet the 0.9Kg of Chuanxiong for 7 hours. Continuously pass the water vapor at 170°C slowly through the wet Rhizoma Chuanxiong, and then condense the mixed steam passing through the wet Rhizoma Chuanxiong to obtain an oil-water mixture, and use a separatory funnel to separate the oil from water to obtain the essential oil of Rhizoma Chuanxiong. Since the components of the Chuanxiong essential oil extracted by the above method cannot be consistent with the precise values ​​required by the experimenter, pure ligustilide, pure cnidactone A and pure neocnilide were used in the examples. To adjust the extracted Chuanxiong essential oil, the adjusted Chuanxiong essential oil includes 13% ligustilide, 9% cnidactone A and 9% cnidactone, and the remaining components are other esters.

Embodiment 3

[0034]The initial essential oil of Chuanxiong was prepared by the following steps: 1.1Kg of Chuanxiong was pulverized to a particle size of 7mm, and then mixed with 0.33Kg of deionized water, and 1.1Kg of Chuanxiong was wetted for 20 hours. Continuously pass the water vapor at 200°C slowly through the wet Rhizoma Chuanxiong, and then condense the mixed steam passing through the wet Rhizoma Chuanxiong to obtain an oil-water mixture, and use a separatory funnel to separate the oil from water to obtain the essential oil of Rhizoma Chuanxiong. Since the components of the Chuanxiong essential oil extracted by the above method cannot be consistent with the precise values ​​required by the experimenter, pure ligustilide, pure cnidactone A and pure neocnilide were used in the examples. To adjust the extracted Chuanxiong essential oil, the adjusted Chuanxiong essential oil includes 15% ligustilide, 15% cnidactone A and 10% neocni lactone, and the remaining components are other esters. ...

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Abstract

The invention provides novel application of rhizoma chuanxiong essential oil in the pharmaceutical field, and particularly relates to application of the rhizoma chuanxiong essential oil in preparation of a medicine for treating degenerative osteoarthropathy. The rhizoma chuanxiong essential oil can effectively improve the physical and chemical properties of synovial fluid and improve symptoms, such as pain and swelling, of a patient. The rhizoma chuanxiong essential oil can effectively treat the degenerative osteoarthropathy, such as herniated disk, foraminal stenosis, meniscus injury and osteoproliferation. The rhizoma chuanxiong essential oil is convenient to prepare and use; the patient can use the rhizoma chuanxiong essential oil conveniently, and the rhizoma chuanxiong essential oil is low in toxic and side effect.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to the application of chuanxiong essential oil in the preparation of medicine for treating degenerative osteoarthrosis. Background technique [0002] Degenerative osteoarthritis, also known as osteoarthritis, degenerative arthritis, senile arthritis, and hypertrophic arthritis, is a degenerative disease caused by aging, obesity, strain, trauma, congenital abnormalities of joints, joint Degeneration of articular cartilage, joint margins and reactive hyperplasia of subchondral bone caused by many factors such as deformity. The disease is more common in middle-aged and elderly people, and it is more likely to occur in weight-bearing joints and joints with more activities (such as cervical spine, lumbar spine, knee joints, hip joints, etc.). Excessive weight bearing or use of these joints can promote degenerative changes. Clinical manifestations include slowly developing joint pain, tenderness...

Claims

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Application Information

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IPC IPC(8): A61K36/236A61P19/08A61P19/04C11B9/02
CPCA61K36/236C11B9/02C11B9/022C11B9/027
Inventor 曹远东
Owner 四川九渊医药科技有限公司
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