Effervescent tablet production method

A production method and technology of effervescent tablets, applied in the field of effervescent tablets, can solve problems such as inability to disintegrate, and achieve the effects of facilitating disintegration, improving stability, and increasing specific surface area

Inactive Publication Date: 2017-08-04
TIANJIN HORUS CANDK PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The ingredients contain acids and bases. Generally, acids and bases will not react in the absence of water. However, a small amount of water will inevitably be introduced during the granulation and tableting process, resulting in ionization reactions between acids and bases. disintegrate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] A production method of an effervescent tablet, comprising the procedures of granulation, tablet compression and internal packaging.

[0016] The innovation point of the present invention is:

[0017] A drying program was added between the tableting and internal packaging procedures, and the drying was carried out using reduced-pressure drying equipment with a controlled drying pressure of -0.7 to -0.8Mpa, a drying temperature of 45°C, and a drying time of 24 hours.

[0018] Specific steps are as follows:

Embodiment 2

[0020] The difference from Example 1 is that the drying temperature is 50°C.

Embodiment 3

[0022] The difference from Example 1 is that the drying temperature is 55°C.

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PUM

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Abstract

The invention relates to an effervescent tablet production method, comprising pelletizing, tabletting, and a wrapping procedure, and a drying procedure added between the tabletting and the wrapping procedure. A decompression drying device is used in the drying, drying pressure is controlled to be -0.7 Mpa to -0.8 Mpa, temperature is adjusted to be 45-55 DEG C, and drying for 24-72 h. In the method, effervescent tablet is further dried after tabletting formation, so as to eliminate moisture in a tablet, prevent acid-base reaction, and improve stability of long-time storage of tablets.

Description

technical field [0001] The invention belongs to the field of effervescent tablets, relates to a production process of effervescent tablets, in particular to a production method of effervescent tablets. Background technique [0002] An effervescent tablet is a tablet that contains an effervescent disintegrant. So-called effervescent disintegrating agent is usually the mixture of organic acid and sodium carbonate, sodium bicarbonate (baking soda); effervescent tablet itself is dry and does not contain moisture, and the two materials in the effervescent disintegrating agent are not ionized and cannot react; but When the effervescent tablet is put into water, the two substances undergo an acid-base reaction to generate a large amount of carbon dioxide, causing the tablet to disintegrate and melt rapidly. [0003] Usually, the production process of effervescent tablets includes the following procedures in sequence: batching, granulation, tabletting, and packaging. The ingredien...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61J3/10
CPCA61J3/10
Inventor 王建强许培立王春磊
Owner TIANJIN HORUS CANDK PHARMA CO LTD
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