Bone loss protection agent for astronaut and preparation method of bone loss protection agent

A technology for astronaut bone and protective agent, which is applied in bone diseases, pharmaceutical formulations, medical preparations with inactive ingredients, etc. , the effect of improving bioavailability

Active Publication Date: 2017-08-04
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problem of bone loss of astronauts during space flight and overcome the shortcomings of existing protective agents t

Method used

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  • Bone loss protection agent for astronaut and preparation method of bone loss protection agent
  • Bone loss protection agent for astronaut and preparation method of bone loss protection agent
  • Bone loss protection agent for astronaut and preparation method of bone loss protection agent

Examples

Experimental program
Comparison scheme
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Example Embodiment

[0020] Example 1:

[0021] This embodiment provides an astronaut bone loss protective agent and a preparation method thereof. The astronaut bone loss protective agent uses pine polyphenols and black fungus acid polysaccharides as effective ingredients, wherein: pine polyphenols and black fungus acid polysaccharides The mass ratio is 1:10, and the specific preparation steps are as follows:

[0022] 1. Add pine polyphenols and black fungus acid polysaccharides to the PBS solution with pH 8 in a mass ratio of 1:10, and mix well;

[0023] 2. Add polylysine to the mixed solution of step 1, control the mass ratio of polylysine and pine polyphenol to 1:10, and place the mixed solution in an air bath shaker at a temperature of 50°C , React for 6 hours under the condition of rotation speed of 200 revolutions / min, centrifuge, and sediment is the astronaut bone loss protective agent.

Example Embodiment

[0024] Example 2:

[0025] This embodiment provides an astronaut bone loss protective agent and a preparation method thereof. The astronaut bone loss protective agent uses pine polyphenols and black fungus acid polysaccharides as effective ingredients, wherein: pine polyphenols and black fungus acid polysaccharides The mass ratio is 1:5, and the specific preparation steps are as follows:

[0026] 1. Add pine polyphenols and black fungus acid polysaccharides to the PBS solution with pH 7 at a mass ratio of 1:5, and mix well;

[0027] 2. Add polylysine to the mixed solution of step 1, control the mass ratio of polylysine and pine polyphenol to 1:1, and place the mixed solution in an air bath shaker at a temperature of 30°C , React for 4 hours at a speed of 100 revolutions per minute, centrifuge, and the precipitate is the astronaut bone loss protective agent.

Example Embodiment

[0028] Example 3:

[0029] This embodiment provides an astronaut bone loss protective agent and a preparation method thereof. The astronaut bone loss protective agent uses pine polyphenols and black fungus acid polysaccharides as effective ingredients, wherein: pine polyphenols and black fungus acid polysaccharides The mass ratio is 1:8, and the specific preparation steps are as follows:

[0030] 1. Add pine polyphenols and black fungus acid polysaccharides to the PBS solution with pH 7 at a mass ratio of 1:8, and mix well;

[0031] 2. Add polylysine to the mixed solution of step 1, control the mass ratio of polylysine and pine polyphenol to 1:5, and place the mixed solution in an air bath shaker at a temperature of 45°C , React for 5 hours under the condition of rotation speed of 150 rpm, centrifuge, and precipitate is the astronaut bone loss protective agent.

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Abstract

The invention discloses a bone loss protection agent for an astronaut and a preparation method of the bone loss protection agent. The bone loss protection agent comprises effective components pine polyphenol and black fungus acidic polysaccharose, wherein the mass ratio of the pine polyphenol to the black fungus acidic polysaccharose is 1:(5-10). The method comprises the following specific preparation steps of (1) adding the pine polyphenol and the black fungus acidic polysaccharose to a PBS solution of which the pH is 7-8 and mixing evenly; and (2) adding polylysine to the mixed solution in the step (1) for molecular self-assembly and centrifuging and precipitating to obtain the bone loss protection agent for the astronaut. By adopting a molecular self-assembly technology, the pine polyphenol with a preventive treatment effect on bone boss induced by weightlessness, extracted from a natural plant red pine cone scale is taken as a main component, and is coated with the black fungus acidic polysaccharose to form nanoparticles, thereby protecting the active components and improving the bioavailability.

Description

technical field [0001] The invention relates to a bone loss protective agent and a preparation method thereof, in particular to a special bone loss protective agent for astronauts with anti-space bone loss activity. Background technique [0002] Among the pathological changes in the human body caused by space, the bone loss caused by the microgravity effect has attracted the attention of various countries because of the high risk of fracture and high risk of death caused by the overweight environment of the human body returning to the earth. Currently, the equipment developed to prevent bone loss caused by the space environment is weak, and chemical drugs and hormones have serious side effects. Therefore, finding a non-toxic and powerful bone loss preventive agent has become a solution to the problem of the human body adapting to the microgravity environment. one of the ways. [0003] In recent years, natural products have received extensive attention due to their rich reso...

Claims

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Application Information

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IPC IPC(8): A61K36/15A61K31/715A61K47/34A61P19/08A61P19/10
CPCA61K31/715A61K36/15A61K47/34
Inventor 王振宇陈斌刁岩
Owner HARBIN INST OF TECH
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