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Water-soluble lipstick for treating lip crack and preparation method thereof

A water-soluble lip balm technology, applied in the field of biomedicine, can solve problems such as lack of protection, wound deterioration, and high price, and achieve the effect of accelerating wound healing, good therapeutic effect, and wide application to the crowd

Inactive Publication Date: 2017-08-04
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, through market research and research, it has been found that more than 95% of the lipsticks commonly sold on the market are solid lipsticks, which contain a large amount of lipids. Wound aggravation caused by lip balm, especially when it is easy to squeeze and tear the affected area during application
In addition, excessive use of lip balm will make the lips feel heavy and greasy, hinder the normal breathing of the lip skin, and make it difficult to recover from angular cheilitis
[0004] Liquid lipsticks on the market are almost exclusively used for lip gloss makeup, have no therapeutic properties at all, and are expensive

Method used

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  • Water-soluble lipstick for treating lip crack and preparation method thereof

Examples

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Effect test

preparation example Construction

[0050] The preparation method of the above-mentioned water-soluble lipstick for the treatment of chapped lips comprises the steps:

[0051] (1) Take phosphate buffer solution and place it in a sterile container;

[0052](2) Take recombinant human epidermal growth factor, add it to the phosphate buffer solution in step (1), stir and dissolve;

[0053] (3) Take medical chitosan, add it to the mixture in step (2), stir and dissolve;

[0054] (4) Take polylysine, add it to the mixture in step (3), stir and dissolve;

[0055] (5) Take sodium hyaluronate, add it to the mixture in step (4), stir and dissolve;

[0056] (6) Add sodium hydroxide solution to the mixed solution in step (5), stir and mix until the pH value of the mixed solution is 7.0~7.5;

[0057] (7) Use phosphate solution to dilute the mixed solution obtained in step (6), stir and mix;

[0058] (8) Divide the aqueous solution obtained in step (7) into sterile glass bottles and seal them to obtain a water-soluble lip...

Embodiment 1

[0061] S101. Take 50ml of phosphate buffer solution and place it in a sterile container;

[0062] S102. Take 3000 IU of recombinant human epidermal growth factor, add it to the phosphate buffer solution in step S101, stir and dissolve;

[0063] S103. Take 500 mg of medical chitosan, add it to the mixed solution in step S102, stir and dissolve;

[0064] S104. Take 100 mg of polylysine, add it to the mixed solution in step S103, stir and dissolve;

[0065] S105. Take 550 mg of sodium hyaluronate, add it to the mixed solution in step S104, stir and dissolve;

[0066] S106. Add a sodium hydroxide solution with a concentration of 0.1 mol / L to the mixed solution in step S105, stir and mix until the pH of the mixed solution is 7.2;

[0067] S107. Use a phosphate solution to dilute the mixed solution obtained in step S106 to 100 ml, stir and mix;

[0068] S108. Dispensing the aqueous solution obtained in step S107 into sterile glass bottles and sealing them to obtain the water-solu...

Embodiment 2

[0070] According to the preparation process and process of Example 1, samples G2 and G3 were prepared. Among them, the components and proportions of G2 and G3 are shown in Table 1 below.

[0071] Table 1: Recipes for the preparation of G2 and G3

[0072]

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Abstract

The invention provides a water-soluble lipstick for treating lip crack and a preparation method thereof. Every 100 ml of water-soluble lipstick is prepared from, 100-10000 IU recombined human epidermal growth factor, 100-1000 mg of medical chitosan, 100-1000 mg of sodium hyaluronate, 10-200 mg of polylysine, sodium hydroxide solution with pH value adjusted to 7.0-7.5 and concentration of 0.1 mol / L, and phosphate buffer for fixing capacity of mixture of above components to 100 ml. The water-soluble lipstick takes medical chitosan and recombined human epidermal growth factor (hEGF) as the main raw materials; different from the traditional solid lipstick and grease type lipstick, the lipstick can effectively treat moderate and severe lip crack, and the water-soluble lipstick excludes oil grease, is irradiation-free and absorbable.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a water-soluble lipstick for treating chapped lips and a preparation method thereof. Background technique [0002] Chapped lips are a common disease in spring, autumn and winter, which is mainly due to the dry weather, large temperature changes and decreased human body resistance in spring, autumn and winter. Chapped lips and bleeding are actually suffering from angular cheilitis, which is a common oral disease. Spring, autumn and winter are the high incidence seasons of angular cheilitis. In severe cases, mouth opening is easy to bleed, and even eating and speaking are affected. [0003] The healing cycle of chapped lips is generally about one week. During this week, in addition to supplementing vitamins and water, the most common method for patients is to use lip balm to smear their lips. However, through market research and research, it has been found that more than 95% o...

Claims

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Application Information

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IPC IPC(8): A61K38/18A61K9/08A61P17/02A61P29/00A61K31/722A61K31/728A61K31/785
Inventor 王成牛冯展波徐大伟陈唯唯
Owner NANTONG UNIVERSITY