Negative-pressure transdermal drug delivery device
A transdermal drug delivery and negative pressure technology, applied in the direction of drug devices, other medical devices, etc., can solve the problem that the transdermal penetration speed is difficult to meet the long-term stable treatment and other problems
Pending Publication Date: 2017-08-08
柴雪青
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Problems solved by technology
Due to the barrier effect of the skin, the transdermal penetration rate of most drugs, even those with low doses and high efficacy, cannot meet the needs of long-term stable treatment
Method used
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[0024] Example, prepare a Dahuoluodan (produced by Beijing Tongrentang (Group) Co., Ltd., China), dissolve it with rice wine, and then apply it to the compound drug dressing, load the negative pressure transdermal drug delivery device on the skin of the leg, and turn on Negative pressure, the vacuum degree in the negative pressure transdermal device reaches 0.05mpa. After 5 minutes, the drug penetrates into the legs, and the curative effect is felt in the legs after 10 minutes. The drug is stopped in 15 minutes. After the negative pressure transdermal administration Within 72 hours, the legs feel good, the walking is strong, the curative effect is remarkable, and there is no discomfort feeling, and the effect of negative pressure transdermal administration is better than that of oral administration.
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The invention provides a negative-pressure transdermal drug delivery device and aims to solve the problems that a conventional transdermal drug delivery device injures skin in the use process and is low in transdermal drug delivery curative effect. The technical key points are that a composite drug-loaded dressing containing a drug is loaded into the negative-pressure transdermal drug delivery device, a meshy elastic member fixed at the edge of the inner wall is arranged in the position, in contact with the skin, of the negative-pressure transdermal drug delivery device, and a semi-circular member allowing air to pass is arranged in the internal middle of the negative-pressure transdermal drug delivery device. After negative pressure is pumped into the negative-pressure transdermal drug delivery device, the surface area of the skin per unit area is increased, the skin tissue space is enlarged, and further, the drug transdermal impedance is reduced. Along with increase of the negative pressure, the meshy elastic member and the semi-circular member in the negative-pressure transdermal drug delivery device limits swelling of the skin and tissues, a reversed pushing action force is formed on the skin in negative pressure due to action of resistance, so that the drug can be easily loaded into the skin and enters a human body through the space-enlarged skin and tissues, and after relief of the negative pressure, the human body skin tissues recover while the drug remains in the human body.
Description
technical field [0001] The technology belongs to a drug delivery device in the field of transdermal drug delivery. Background technique [0002] The concept of "transdermal technology" comes from the United States in 1974. The so-called transdermal technology (trandermal therapeutic systems, TTS) is a new way of non-invasive drug delivery, which refers to drug delivery on the surface of the skin, so that the drug can pass through all layers of the skin. The method of entering the human body and circulatory system to produce systemic or local therapeutic effects is an important breakthrough in the traditional concept of skin medicine, and the research in this new field is very active at present. [0003] Compared with other drug delivery methods, the transdermal drug delivery technology has its unique advantages. The advantages are as follows: First, the transdermal drug delivery will not cause "first-pass effect" to the human liver and damage the liver function, and will not...
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IPC IPC(8): A61M37/00
CPCA61M37/00A61M2037/0007
Inventor 柴佳良柴雪青
Owner 柴雪青
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