Polypeptide for removing iron and free radicals in brain and preparation method and application thereof

A technology for free radicals and iron reduction, applied in the field of preparation of peptides for reducing iron and removing free radicals in the brain, can solve the problems of ineffective treatment, reducing free radicals, unclear causes of disease, etc., achieving significant therapeutic effects and reducing free radicals. base, the effect of protecting brain tissue

Inactive Publication Date: 2017-08-08
GUILIN MEDICAL UNIVERSITY
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Problems solved by technology

[0002] Alzheimer's Disease (Alzheimer's Disease, Alzheimer's disease) is a kind of neurodegenerative disease, because a large number of necrosis of neurons, causes brain atrophy, thus can cause loss of memory, mental disorder, language disorder and personality variation; The family brings great troubles and burdens, the cause of the disease is still unclear, and there is still no effective treatment
[0003] Studies have shown that the brain iron content of Alzheimer's patients is about 35% higher than that of normal brains. During the process of metabolic life activities, organisms will continuously generate some oxidative active substances, such as H 2 o 2 etc., can be compared with Fe 2+ The ions react to generate free radicals, and the generated free radicals can further interact with biological macromolecules in the body, destroying lipids and proteins in tissues and cells, resulting in cell damage and tissue necrosis; therefore, removing redun

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  • Polypeptide for removing iron and free radicals in brain and preparation method and application thereof
  • Polypeptide for removing iron and free radicals in brain and preparation method and application thereof
  • Polypeptide for removing iron and free radicals in brain and preparation method and application thereof

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Embodiment 1

[0025] An embodiment of the present invention provides a method for preparing a polypeptide for reducing iron and removing free radicals in the brain, the method comprising:

[0026] Combining the iron-binding amino acids in the polypeptide Aβ42 according to a predetermined number of repetitions to obtain the polypeptide; wherein, the iron-binding amino acids include: histidine (abbreviated as H), phenylalanine (abbreviated as A), tyrosine acid (referred to as Y), glutamic acid (referred to as E), aspartic acid (referred to as D).

[0027] In the above-mentioned examples, because the optimal polypeptide length of the current polypeptide synthesis process is about 45 amino acids, the length of the polypeptide sequence repeated 5 times in (HAYED) plus the previous sequence of 5 amino acids is a total of 30 amino acids, which is guaranteed to reach On the premise of better beneficial effects, the polypeptide synthesis process is relatively easy to implement; therefore, as a prefe...

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Abstract

The present invention provides comprises a polypeptide for removing iron and free radicals in brain and a preparation method and application thereof, the preparation method comprises combination of amino acids capable of binding iron in polypeptide A beta 42 according to predetermined times of repetition to obtain the polypeptide. The polypeptide obtained by the method has larger solubility, can effectively chelate iron ions in cerebrospinal fluid of patients with Alzheimer's disease, and can effectively reduce the free radicals.

Description

technical field [0001] The invention relates to the technical field of polypeptide synthesis, in particular to a polypeptide for reducing iron and removing free radicals in the brain, a preparation method and an application. Background technique [0002] Alzheimer's Disease (Alzheimer's Disease, Alzheimer's disease) is a kind of neurodegenerative disease, because a large number of necrosis of neurons, causes brain atrophy, thus can cause loss of memory, mental disorder, language disorder and personality variation; The family brings great troubles and burdens, the cause of the disease is still unclear, and there is still no effective treatment. [0003] Studies have shown that the brain iron content of Alzheimer's patients is about 35% higher than that of normal brains. During the process of metabolic life activities, organisms will continuously generate some oxidative active substances, such as H 2 o 2 etc., can be compared with Fe 2+ The ions react to generate free radic...

Claims

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Application Information

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IPC IPC(8): C07K14/47A61K38/17A61P25/28
CPCA61K38/00C07K14/4711
Inventor 邹珍友蔡静范奕好赵强黄洁姜月李林陈丽冠郑洪杰吴登强吴寒冰陈超群
Owner GUILIN MEDICAL UNIVERSITY
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