Berberine-carried carboxymethyl Beta-cyclodextrin functional montmorillonite drug releasing system
A technology of carboxymethyl cyclodextrin and cyclodextrin, applied in the field of plant active ingredient berberine, can solve the problems of affecting the release and absorption of active ingredient berberine, easy aggregation and precipitation of montmorillonite particles, etc. The effect of improving utilization, drug loading and drug release
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Embodiment 1
[0047] Example 1 Preparation of carboxymethyl β-cyclodextrin functionalized montmorillonite material
[0048] Preparation of Carboxymethylcyclodextrin (CMCD)
[0049] Weigh 9.3g of sodium hydroxide into a round bottom flask, add 37mL of deionized water and place in an ice-water bath and stir until completely dissolved. Add 10g of β-cyclodextrin and stir to dissolve. Prepare 27mL of 16.3% monochloroacetic acid aqueous solution and set aside. Place the above-mentioned round-bottomed flask in a constant temperature water bath at 60°C, slowly add an aqueous solution of chloroacetic acid (completely added within 20 minutes) dropwise, and after reacting for 5 hours, pour the reaction solution into a large beaker, and drop while stirring after cooling. Add concentrated hydrochloric acid until the pH test paper detects that it is neutral. Add a large amount of anhydrous methanol to the beaker, stir rapidly, and a white precipitate can be seen. Suction filtration, collect the white...
Embodiment 2
[0062] Embodiment 2 The establishment of berberine hydrochloride ultraviolet spectrophotometry content determination method
[0063] Determination of Ultraviolet Absorption Wavelength of Berberine Hydrochloride (BBH)
[0064] Accurately weigh 18 mg of berberine hydrochloride standard product dried at 105°C to constant weight, dissolve it completely with ultrapure water, and then set the volume in a 25 mL volumetric flask to obtain a berberine hydrochloride stock solution. Precisely draw 1 mL of berberine hydrochloride stock solution into a 25 mL volumetric flask to make up to volume, and finally prepare a berberine hydrochloride solution with a concentration of 29 μg / mL. The absorbance was measured by scanning in the range of 200-600 nm with a UV-Vis spectrophotometer. The results showed that berberine hydrochloride had maximum absorption at three wavelengths of 228, 263, and 345nm. In order to avoid the possible interference of impurities near the low wavelength of 200nm, th...
Embodiment 3
[0073] Example 3 CMCD-APTES-MMT Supramolecular Network Material Drug Loading Performance Examination Experiment
[0074] Calculate the drug loading rate of CMCD-APTES-MMT according to the following formula:
[0075]
[0076] Effect of drug loading time on drug loading rate
[0077] Weigh 50mg of berberine hydrochloride into a round bottom flask, add 100mL of ultrapure water and heat to dissolve, weigh 100mg of CMCD-APTES-MMT and evenly disperse in the above drug solution, keep stirring, and at the selected time point: 0.5, 1, 2 , 3, 4, 5, and 6 hours, precisely draw the suspension, centrifuge at 12,000 rpm for 5 minutes, collect the supernatant, and filter the supernatant with a 0.45 μm microporous membrane to remove suspended particles. The content of free berberine hydrochloride in the supernatant was determined by ultraviolet spectrophotometry at a wavelength of 345nm. All samples were tested in triplicate in parallel. Depend on Figure 5 It can be seen that the drug...
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