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A kind of preparation method of fast-expandable ultra-porous composite hemostatic material

A technology of hemostatic materials and composite materials, which can be used in medical formulations, surgical adhesives, operations, etc., and can solve problems such as lack of expansion properties

Active Publication Date: 2020-06-30
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nevertheless, composites of mesoporous bioactive glass and chitosan do not possess swelling properties, so this material cannot stop bleeding in a swelling-blocking manner

Method used

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  • A kind of preparation method of fast-expandable ultra-porous composite hemostatic material
  • A kind of preparation method of fast-expandable ultra-porous composite hemostatic material

Examples

Experimental program
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Effect test

Embodiment 1

[0022] Example 1 Preparation of a rapidly expandable superporous composite hemostatic material

[0023] A) Mix 3.0 grams of water, 0.1 grams of figure 1 10nm pore size shown, containing SiO 2 , CaO, P 2 o 5 and Ag 2 O's mesoporous reactive glass powder, 0.05 g chitosan, 0.2 g foaming agent sodium bicarbonate and different polyacrylamide monomers including 0.2 g acrylamide, 0.033 g N,N-methylene-bisacrylamide , 0.010 gram of ammonium persulfate and 0.015 gram of tetramethylethylenediamine are mixed to form a mixture M;

[0024] B) stirring the mixture M to generate bubbles, and then placing it in an environment with a temperature of 400° C. and a humidity of 90% for 12 hours to obtain a composite material composed of mesoporous active glass powder, chitosan and polyacrylamide;

[0025] C) The composite material composed of mesoporous active glass powder, chitosan and polyacrylamide was soaked in absolute ethanol at 40°C for 40 hours, then put into a vacuum desiccator to dr...

Embodiment 2

[0027] Embodiment 2 arterial hemostasis embodiment

[0028] Sixteen healthy adult SD rats, weighing 190±15 grams, were provided by the Experimental Animal Center of Chengdu High-tech Zone. They were randomly divided into 4 groups with 4 rats in each group. The first group was pure mesoporous bioactive glass powder, and the second group It is Celox chitosan quick-acting hemostatic powder, the third group is mesoporous bioglass-chitosan porous composite hemostatic material, and the fourth group is mesoporous bioglass-chitosan-polyacrylamide composite superporous hemostatic material. Rats were intraperitoneally injected with pentobarbital sodium 40 mg / kg, and fixed on the operating table on their backs after anesthesia. The common carotid artery was peeled off ~ 2 cm, the proximal end was clamped, the other end was tied with a degradable surgical thread, an incision was made transversely along the artery, and a catheter was inserted from the incision and fixed. Open the hemostat...

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Abstract

The invention relates to an ultra-porous composite hemostatic material capable of expanding rapidly, and a preparation method and application thereof. According to the preparation method for the ultra-porous composite hemostatic material, mesoporous active glass, chitosan, a foaming agent and different polyacrylamide monomers are mixed at first and then subjected to initiation to form bubbles and polyacrylamide, and an ultra-porous structure containing three components, i.e., mesoporous active glass, chitosan and polyacrylamide, is eventually obtained. The ultra-porous composite hemostatic material can rapidly expand and rapidly promote blood coagulation and has good antibacterial properties and biocompatibility. The ultra-porous composite hemostatic material can rapidly stop arterial hemorrhage ad has better effect compared with hemostatic materials made of single mesoporous active glass or chitosan or made of dual components consisting of mesoporous active glass and chitosan.

Description

technical field [0001] The invention relates to a composite hemostatic material and its preparation technology, in particular to a rapidly expandable superporous composite hemostatic material, a composition method and application of the superporous composite hemostatic material, and belongs to the field of biomedical materials. Background technique [0002] In daily life, it is very important to quickly stop bleeding caused by various reasons. Especially for those patients with massive arterial hemorrhage, early control of arterial hemorrhage becomes the best strategy to reduce the death of patients. For arterial bleeding, an ideal hemostatic material should be able to rapidly expand and coagulate blood quickly, so that the damaged artery can be quickly blocked and coagulate quickly to form a thrombus, thereby preventing blood loss. At the same time, the material should also have good biocompatibility and antibacterial properties. This will avoid infection or rejection in ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/08A61L24/06A61L24/02A61L24/00
CPCA61L24/001A61L24/0036A61L24/02A61L24/06A61L24/08A61L2400/04C08L5/08C08L33/26
Inventor 洪友良郭波
Owner SICHUAN UNIV
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