Oral hemostasis and repair material and preparation method thereof

A technology for repairing materials and oral cavity, which can be applied in pharmaceutical formula, prosthesis, drug delivery, etc. It can solve the problems of high biocompatibility and low immunogenicity, achieve good hemostatic performance, promote bone healing, and high safety Effect

Pending Publication Date: 2020-05-22
SHAANXI BIO REGENERATIVE MEDICINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The material has low immunogenicity, high biocompatibility, and is biodegradable, but it does not have the effect of repairing the damaged part after hemostasis after the extraction socket

Method used

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  • Oral hemostasis and repair material and preparation method thereof
  • Oral hemostasis and repair material and preparation method thereof
  • Oral hemostasis and repair material and preparation method thereof

Examples

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Comparison scheme
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Embodiment 1

[0027] The invention provides a oral cavity hemostatic and repair material, which is prepared from the following components in parts by weight: 40 parts of decalcified bone granules, 20 parts of carboxymethyl chitosan, vitamin E 40 parts of acetate.

[0028] In some embodiments, the parts by weight of the decalcified bone particles are 30 parts, 31 parts, 32 parts, 33 parts, 34 parts, 35 parts, 36 parts, 37 parts, 38 parts, 39 parts, 41 parts, 42 parts, 43 parts, 44 parts, 45 parts, 46 parts, 47 parts, 48 ​​parts, 49 parts or 50 parts; The parts by weight of described carboxymethyl chitosan are 10 parts, 11 parts, 12 parts, 13 parts parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts or 20 parts; the parts by weight of the vitamin E acetate are 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts parts, 26 parts, 27 parts, 28 parts, 29 parts, 30 parts, 31 parts, 32 parts, 33 parts, 34 parts, 35 parts, 36 parts, 37 parts, 38 parts, 39 parts, 40 parts, 41 pa...

Embodiment 2

[0031] The present embodiment provides the preparation method of oral hemostatic and repair material described in embodiment 1, comprising the following steps:

[0032] 1) After heating 40 parts of vitamin E acetate at 70°C, add 20 parts of carboxymethylcellulose sodium into the hot vitamin E acetate and mix evenly, then cool at room temperature to obtain hemostatic cement;

[0033] 2) Add 40 parts of decalcified bone granules to the above-mentioned hemostatic cement, blend and glue, and then obtain a porous structure, plastic, and degradable and absorbable oral hemostatic and repair material after molding, packaging, and sterilization.

[0034] The decalcified bone granules are prepared by the following method: bovine femur is pulverized into a natural bone powder with a particle size not greater than 600 μm, and ultrasonically cleaned with purified water for 3 times, each time for 10 minutes; The natural bone powder was soaked in 3 times the weight of absolute ethanol for 2 ho...

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Abstract

The present invention provides an oral hemostasis and repair material. The oral hemostasis and repair material is prepared by the following components in parts by weight: 30-50 parts of decalcified bone particles, 10-20 parts of carboxymethyl chitosan and 20-60 parts of vitamin E acetate. The decalcified bone particles in the oral hemostasis and repair material can be used as carriers of the oralhemostasis and repair material, a contained collagen structure has an induction effect on mineral deposition of bone substances of the wound, the decalcified bone particles are combined with growth factors and other bone graft materials, so that the oral hemostasis and repair material can effectively initiate and control a mineralization process and promote formation of new bones, thereby enhancing an effect of the oral hemostasis and repair material on induction of new bone regeneration at defect sites after tooth extraction.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to an oral cavity hemostatic and repair material and a preparation method thereof. Background technique [0002] Hemorrhage after tooth extraction is a common complication after tooth extraction, with an incidence rate between 0 and 26%. Most of them are caused by local factors. If not treated in time, it can lead to serious complications. Reasonable selection and application of local hemostatic materials to cover and / or fill the extraction socket are important measures for the treatment and prevention of post-extraction bleeding. Due to its special anatomical characteristics (the extraction socket is surrounded by the proper alveolar bone to form a bone wall), it is most effective to directly pressurize the extraction socket and / or use hemostatic materials to fill and / or cover the extraction socket How to prevent and manage bleeding after tooth extraction. Clinical...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/20A61L27/36A61L27/50A61L27/58
CPCA61L27/20A61L27/3608A61L27/3687A61L27/58A61L27/50A61L2400/04C08L5/08
Inventor 徐宝艳
Owner SHAANXI BIO REGENERATIVE MEDICINE CO LTD
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