Pharmaceutical composition prepared on basis of accompanying principle and application thereof to drug treatment

A composition and drug technology, applied in the field of traditional Chinese medicine, can solve the problems of unspecified main active ingredients and chemical components of traditional Chinese medicine preparations

Active Publication Date: 2017-09-05
林嗣松 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The Chinese invention patent with application number 201410388420.1 discloses a pure Chinese medicine preparation for detoxification, which has a good effect on detoxification and analgesia, but it does not specify the main active ingredients and specific chemical ingredients contained in the Chinese medicine preparation

Method used

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  • Pharmaceutical composition prepared on basis of accompanying principle and application thereof to drug treatment
  • Pharmaceutical composition prepared on basis of accompanying principle and application thereof to drug treatment
  • Pharmaceutical composition prepared on basis of accompanying principle and application thereof to drug treatment

Examples

Experimental program
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Effect test

Embodiment 1

[0034] The preparation of embodiment 1 component A extract

example 1

[0036] (1) Take 1.0kg of Aconitum aconitum and 10g of Ligusticum chuanxiong, grind to 10-200 mesh, mix well, and obtain the material;

[0037] (2) Spray an appropriate amount of ammonia water (about 15-20mL) into the material obtained in step (1), seal and infiltrate for 10-20 minutes, add absolute ethanol (about 3.0kg), and ultrasonically extract at room temperature for 30 minutes , the ultrasonic frequency is 30kHz, filters, and the filtrate is concentrated under reduced pressure and reclaims ethanol to obtain the crude extract (about 200g);

[0038] (3) adding mass fraction in the crude extract that step (2) obtains is that 1% hydrochloric acid adjusts pH to 2-5, then adds ammoniacal liquor and adjusts pH to 9-11, then extracts 3 times with chloroform, merges organic phase, subtracts Concentrate under reduced pressure to obtain a concentrate, and vacuum-dry at 50° C. for 12 hours to obtain an extract of component A (about 120 g, referred to as product A1, and the main compo...

example 2

[0040] (1) Take 1.0 kg of Aconitum aconitum and 5.0 kg of Rhizoma Chuanxiong, grind to 10-200 mesh, mix well, and obtain the material;

[0041] (2) Spray an appropriate amount of ammonia water (about 100mL) into the material obtained in step (1), seal and infiltrate for 20-30 minutes, add absolute ethanol (about 48kg), soak and extract at 60°C for 6 hours, filter , the filtrate was concentrated under reduced pressure and recovered ethanol to obtain the crude extract (about 240g);

[0042] (3) adding mass fraction to the crude extract obtained in step (2) is 3% hydrochloric acid to adjust the pH to 2-5, then add ammonia water to adjust the pH to 9-11, then extract 5 times with ethyl acetate, and combine the organic phases , concentrating under reduced pressure to get the concentrate, vacuum drying at room temperature for 24 hours to get component A extract (about 135g, referred to as product A2, the HPLC collection of illustrative plates of product A2 is basically consistent wi...

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Abstract

The invention relates to a pharmaceutical composition prepared on the basis of an accompanying principle and application thereof to drug treatment. On the basis of a plant extract accompanying principle, the pharmaceutical composition is prepared from a component A, a component B, a component C and a component D, wherein the component A is prepared from extracts of 1 to 10 parts by weight of aconitum sinomontanum nakai and 0.1 to 5 parts by weight of rhizoma chuanxiong; the component B is prepared from extracts of 1 to 15 parts by weight of rhizoma corydalis and 1 to 20 parts by weight of radix panacis quinquefolii; the component C is prepared from extracts of 1 to 10 parts by weight of sarcandra glabra and 1 to 10 parts by weight of liquorice root; the component D is prepared from 0.01 to 0.5 part by weight of calculus bovis and 0.01 to 0.5 part by weight of vitamin B6.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a pharmaceutical composition prepared based on the accompanying principle and its application in detoxification. Background technique [0002] Drugs not only endanger the physical and mental health of the addicts themselves, but also endanger the happiness and tranquility of the family. The drug problem has become an important factor threatening social security and social stability. At present, there are mainly two kinds of detoxification methods commonly used: one is the artificial physiological forced detoxification method, such as the bucket drainage method implemented in Thailand, the forced march treatment method in India, and the forced labor law in China, etc.; the second is drug detoxification. Drug detoxification methods generally use opioid receptor agonists or antagonists. Physiological forced hard detoxification method makes patients suffer fr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/714A61P25/36A61K31/4415A61K35/413
CPCA61K31/4415A61K35/413A61K36/185A61K36/236A61K36/258A61K36/484A61K36/66A61K36/714A61K2236/33A61K2236/333A61K2236/55A61K2300/00
Inventor 林嗣松王四旺
Owner 林嗣松
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