A kind of preparation method and application of burdock polysaccharide pyrolyzate

A technology of burdock polysaccharide and pyrolysate, which is applied in the field of preparation of burdock polysaccharide pyrolysate, can solve the problems of uneven structure, unstable activity and low activity of burdock polysaccharide, and achieves inhibition of α-glucosidase activity, structure and The effect of stable ingredients and high activity

Active Publication Date: 2020-06-09
博德生物技术(德州)有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problems of inhomogeneous structure, low purity, low activity and unstable activity of the existing burdock polysaccharide, the purpose of the present invention is to provide a preparation method and application of burdock polysaccharide pyrolyzate

Method used

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  • A kind of preparation method and application of burdock polysaccharide pyrolyzate
  • A kind of preparation method and application of burdock polysaccharide pyrolyzate
  • A kind of preparation method and application of burdock polysaccharide pyrolyzate

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preparation example Construction

[0035] A preparation method of burdock polysaccharide pyrolyzate, comprising the following steps:

[0036] ①Add burdock polysaccharide and water with a mass ratio of 1:1~100 into the reaction vessel, and pyrolyze it at a pyrolysis temperature of 100~260°C for 1~8 hours to obtain a mixed solution;

[0037] ②Centrifuge the mixture obtained in step ① at a speed of 1000~10000r / min for 1~5 minutes, take the supernatant and concentrate the volume to 0.5~0.1 times the original volume at 50~100°C to obtain a concentrate;

[0038] ③ Dialyzing the concentrated solution obtained in step ② with a dialysis bag with a molecular weight cut-off of 500-3000 for 1-3 days to obtain a retentate, and drying the retentate to obtain pyrolyzed burdock polysaccharide.

[0039] Preferably, the burdock polysaccharide is prepared according to the following steps:

[0040] ⑴Fresh burdock roots are washed and dried, peeled, sliced, add 2 to 5 times the weight of water, and extract twice at 75~85°C, the fi...

Embodiment 1

[0065] A preparation method of burdock polysaccharide pyrolyzate, comprising the following steps:

[0066] ①Add burdock polysaccharide and water with a mass ratio of 1:1 into the reaction vessel, and pyrolyze it at a pyrolysis temperature of 100°C for 8 hours to obtain a mixed solution;

[0067] ②Centrifuge the mixture obtained in step ① at a speed of 1000r / min for 5 minutes, take the supernatant and concentrate it at 50°C to 0.5 times its original volume to obtain a concentrate;

[0068] ③The concentrated solution obtained in step ② was dialyzed for 1 day with a dialysis bag with a molecular weight cut-off of 500 to obtain a retained solution, which was dried by rotary evaporation to obtain pyrolyzed burdock polysaccharide.

Embodiment 2

[0070] A preparation method of burdock polysaccharide pyrolyzate, comprising the following steps:

[0071] ① Add burdock polysaccharide and water with a mass ratio of 1:100 into the reaction vessel, and pyrolyze it at a pyrolysis temperature of 260°C for 1 hour to obtain a mixed solution;

[0072] ② Centrifuge the mixed solution obtained in step ① at a rotational speed of 10000r / min for 1 minute, take the supernatant and concentrate the volume to 0.1 times the original volume at 100°C to obtain a concentrated solution;

[0073] ③ The concentrated solution obtained in step ② was dialyzed for 3 days with a dialysis bag with a molecular weight cut-off of 3000 to obtain a retentate, which was dried by rotary evaporation to obtain pyrolyzed burdock polysaccharide.

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Abstract

The invention discloses a preparation method and application for a burdock polysaccharide pyrolysate. The preparation method comprises the following steps: adding burdock polysaccharide and water into a reactor, and carrying out pyrolysis at a pyrolysis temperature of 100 to 260 DEG C for 1 to 8 hours so as to obtain a mixed solution; centrifuging the mixed solution for 1 to 5 minutes, taking a supernatant and carrying out concentrating, then carrying out dialysis with a dialysis bag so as to obtain a retention solution, and drying the retention solution so as to obtain the burdock polysaccharide pyrolysate. The preparation method provided by the invention solves the problems of nonuniform structure, low purity, low activity and unstable activity of conventional burdock polysaccharide; the preparation process has less steps and easy operation and is likely to realize large-scale industrial production; the burdock polysaccharide pyrolysate obtained by using the preparation method provided by the invention can significantly inhibit the activity of alpha-glucosidase, significantly reduces the content of blood glucose in mammalian serum, does not generate adverse effects like hepatotoxicity, nephrotoxicity and frequent blood glucose fluctuation, has good curative effects, is non-toxic, and can be applied to hypoglycemic drugs for the needs of clinic treatment of diabetes.

Description

technical field [0001] The invention relates to the technical field of polysaccharides, in particular to a preparation method and application of burdock polysaccharide pyrolyzate. Background technique [0002] With the improvement of people's living standards, people are increasingly pursuing the nutritional value, health care and medicinal value of products. Burdock polysaccharides can be used not only as raw materials for medical and health products, but also for anti-fatigue, anti-aging and brain-building products. Medicines, but at present the burdock products in our country only stay at the simple primary processing level such as salting and shredding, the added value of the products is not high, and the medicinal efficacy of burdock polysaccharides cannot be fully exerted. [0003] In addition, type 2 diabetes has become a chronic disease that seriously threatens human health. Although the current clinically used chemical hypoglycemic drugs have the advantages of good...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/00A61P3/10
CPCC08B37/0003Y02P20/582
Inventor 张硕陈锵陈希瑞
Owner 博德生物技术(德州)有限公司
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