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Preparation method of pseudo-ginseng extract for toothpaste

A technology of extract and notoginseng, which is applied in the field of preparation of notoginseng extract for toothpaste, can solve the problems of low content of active ingredients, low extraction efficiency, high process cost, etc., and achieve the goal of improving symptoms, improving extraction efficiency and shortening extraction time Effect

Inactive Publication Date: 2017-09-08
广东康王日化有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Commonly used processes such as percolation, cold immersion, and water extraction and alcohol precipitation for the extraction of Panax notoginseng, but such extraction processes are time-consuming and have low extraction efficiency, resulting in high process costs and low content of active ingredients
In addition, traditional extraction methods use organic solvents as extractants, resulting in more solvent residues in the extracts contained in toothpaste.

Method used

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  • Preparation method of pseudo-ginseng extract for toothpaste

Examples

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Comparison scheme
Effect test

Embodiment 1

[0019] A preparation method of a notoginseng extract for toothpaste, comprising the following steps: (1) washing the notoginseng conforming to the 2015 edition of the Chinese Pharmacopoeia with water, drying it naturally, and drying it in a vacuum drying oven at 50°C for 12 hours, After being pulverized by a traditional Chinese medicine pulverizer, pass through an 80-mesh pharmacopoeia sieve; (2) Take a certain amount of betaine and glycerin and mix them in a molar ratio of 1:2, and heat them at 80°C and 300rpm for 1.5 hours to form a uniform and transparent Melting reagent; (3) Mix the deep eutectic reagent and 0.25g / ml dipotassium hydrogen phosphate salt solution at a mass volume ratio of 0.3 to form a two-phase aqueous phase, and add Panax notoginseng with a mass volume ratio of 0.04 to the two-water phase After powdering, ultrasonic power of 350W, microwave power of 150W, and 35°C were sonicated for 20 minutes, centrifuged at 3000rpm for 8 minutes, and the lower phase was t...

Embodiment 2

[0021] A preparation method of a notoginseng extract for toothpaste, comprising the following steps: (1) washing notoginseng conforming to the 2015 edition of the Chinese Pharmacopoeia with water, drying naturally, and drying in a vacuum oven at 50°C for 11 hours, After being pulverized by a traditional Chinese medicine pulverizer, pass through an 80-mesh pharmacopoeia sieve; (2) Take a certain amount of choline chloride and urea according to the molar ratio of 1:2, mix them, and heat them at 80°C and 400rpm for 2 hours to form a uniform and transparent Deep eutectic reagent; (3) Mix the deep eutectic reagent with 0.2g / ml sodium sulfate solution at a mass volume ratio of 0.3 to form a two-phase aqueous phase, and add Panax notoginseng powder with a mass volume ratio of 0.03 to the two-water phase After ultrasonic power of 400W, microwave power of 100W, ultrasonication for 25min at 30°C, centrifugation at 2500rpm for 10min, the lower phase was taken out after centrifugation to o...

Embodiment 3

[0023] A preparation method of a notoginseng extract for toothpaste, comprising the following steps: (1) washing the notoginseng conforming to the 2015 edition of the Chinese Pharmacopoeia with water, drying it naturally, and drying it in a vacuum drying oven at 50°C for 12 hours, After being pulverized by a traditional Chinese medicine pulverizer, pass through an 80-mesh pharmacopoeia sieve; (2) Take a certain amount of choline chloride, L-carnitine, lactic acid, and water in a molar ratio of 1:2:1, and then heat it at 80°C and 450rpm After 2 hours, a uniform and transparent deep eutectic reagent is formed; (3) The deep eutectic reagent is mixed with 0.4 g / ml sodium citrate solution at a mass volume ratio of 0.4 to form a two-phase water, and the two-water phase is added The Panax notoginseng powder with a mass volume ratio of 0.03 is ultrasonicated at 450W ultrasonic power, 150W microwave power, and 35°C for 20 minutes, then centrifuged at 3000rpm for 8min, and the lower phas...

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Abstract

The invention discloses a preparation method of a pseudo-ginseng extract for toothpaste. In the method, pseudo-ginseng crude medicines are crushed, an aqueous two-phase system formed by a natural eutectic reagent and a salt solution is used as an extraction agent, centrifugation is performed after being processed by microwave-ultrasound with ultrasonic power of 100-400W and microwave power of 100-200W at the temperature of 20-50 DEG C, a bottom phase taken out after centrifugation is the pseudo-ginseng extract for the toothpaste. By using the preparation method provided by the invention, an extract yield can be improved, and meanwhile extraction time can be significantly shortened. In addition, the eutectic reagent which is green, environment-friendly and good in physiological compatibility is used as the extraction agent, so that the condition that the extract does not include organic solvent is ensured, and the extract is reduced in irritation so as to be more accordant with the requirement of environment protection. By adding the pseudo-ginseng extract acquired according to the preparation method provided by the invention into the toothpaste, improvement effect of the toothpaste on symptoms such as dental ulcer, dental plaque, gingivitis and gingival bleeding can be significantly enhanced.

Description

technical field [0001] The invention relates to the technical field of fine chemicals, more specifically, the invention relates to a method for preparing a toothpaste extract of Panax notoginseng. Background technique [0002] Panax notoginseng is Araliaceae plant Panax notoginscng (Burk.) F. H. Chen's dry root, also known as Shanqi, Jinbuhuan, Tianqi and so on. Mainly produced in Yunnan, Guangxi and other places, wild or cultivated. Radix Notoginseng is sweet in nature, slightly bitter, warm. Mainly the liver, stomach, and large intestine meridian, it has the functions of "removing blood stasis, stopping bleeding, reducing swelling and relieving pain". In terms of its function, "Compendium of Materia Medica" records Panax notoginseng: "Stop bleeding, disperse blood, and relieve pain. For those who have wounds from golden blade arrows, sores from falling sticks, and bleeding that does not stop It also treats hematemesis, hemorrhage, bloody dysentery, metrorrhagia, menst...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61Q11/00A61P1/02A61P7/04
Inventor 柯训忠
Owner 广东康王日化有限公司
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