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Preparation method of hydroxyapatite micropatterning surface having antibacterial property

A technology of hydroxyapatite and micropatterns, which is applied in the fields of bionic engineering and biomedical engineering material preparation, can solve the problems of difficult eradication of biofilms, achieve the effects of reducing body burden, good biocompatibility, and avoiding drug allergic reactions

Inactive Publication Date: 2017-09-08
TIANJIN UNIV
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Problems solved by technology

However, it is very challenging. Since the infection of orthopedic implants is mainly attributed to the formation of biofilm on its surface, and once the biofilm is formed, it is extremely difficult to eradicate, so how to effectively prevent the formation of biofilm on the surface of orthopedic implants is a major issue in biomedicine. One of the unresolved problems in the world

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  • Preparation method of hydroxyapatite micropatterning surface having antibacterial property

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Embodiment

[0026] Embodiment: A method for preparing a hydroxyapatite micropatterned surface with antibacterial properties, the steps of the method are as follows:

[0027] Step (1): Prepare a framework with a micro / nano-scale topological structure on a silicon substrate. The micro / nano-scale refers to the scale range from ten microns to ten nanometers. The micro / nano-scale topological structure includes: micro / nano-scale Columnar arrays, protrusion arrays, pit arrays or groove arrays;

[0028] In the step (1), the framework of the micro / nano-scale topological structure is prepared on the silicon material substrate by photolithography, and the specific process steps are as follows:

[0029] S1. Photomask design: Use L-Edit (Tanner Research, Inc.) software to design photomasks corresponding to micro / nanoscale columnar arrays, protrusion arrays, pit arrays or groove arrays;

[0030] S2. Growth of silicon dioxide film layer by thermal oxidation method: use "wet oxidation method" to oxidize...

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Abstract

The invention discloses a preparation method of a hydroxyapatite micropatterning surface having an antibacterial property. The preparation method comprises the following main steps: firstly preparing a framework with a micro / nano-scale topological structure on a silicon material substrate; then preparing a hydroxyapatite target; then preparing a hydroxyapatite ultra-thin coating; finally thermally treating to obtain the hydroxyapatite micropatterning surface. The prepared micropatterning surface provides a non-medication strategy capable of producing the antibacterial property purely through the physical pattern and the size effect without the aid of chemical ingredients or medicine ingredients, as the antibacterial property is produced without the aid of medicines like antibiotics, the drug allergic reaction of a patient is effectively avoided, and the body burden of the patient is greatly alleviated.

Description

technical field [0001] The invention belongs to the technical field of bionic engineering and biomedical engineering material preparation, and in particular relates to a method for preparing a hydroxyapatite micropatterned surface with antibacterial properties. Background technique [0002] In recent years, the problem of population aging has become increasingly prominent, and orthopedic diseases such as hip joint disease, knee joint disease and intervertebral disease have increasingly plagued the daily life of middle-aged and elderly people. In view of the ever-increasing health care needs of the people, more and more families and society have paid more and more attention to orthopedic implant surgery such as artificial joint replacement surgery. However, there is still a certain proportion of postoperative infection in this type of operation, and infection can cause complete failure of the operation, and even serious consequences such as death of the patient. Therefore, i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/32A61L27/50A61L27/02
CPCA61L27/32A61L27/025A61L27/50A61L2420/02
Inventor 葛翔鲁雄王科锋任富增邓晓帆王瑾杨蕾刘伟峰尚腾飞丁永会杨梦
Owner TIANJIN UNIV
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