Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of amoxicillin soluble powder and preparation method thereof

A technology of amoxicillin and amoxicillin trihydrate, which is applied in the field of amoxicillin soluble powder and its preparation, can solve the problems of loss of activity and rupture, and achieve the effect of not being easy to agglomerate

Active Publication Date: 2020-09-01
山东福美乐动物药业有限公司
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, amoxicillin is a semi-synthetic penicillin antibiotic belonging to the β-lactam structure, which is easily hydrolyzed by acid, alkali, water and penicillinase and loses its activity.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of amoxicillin soluble powder and preparation method thereof
  • A kind of amoxicillin soluble powder and preparation method thereof
  • A kind of amoxicillin soluble powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1 (preparation of 80% amoxicillin soluble powder)

[0030] Ingredients: Amoxicillin trihydrate 800g, polyethylene glycol 6000 150g, beta cyclodextrin 50g.

[0031] Preparation:

[0032] 1. Beta cyclodextrin pretreatment

[0033] In 500L of water, add 200kg of beta-cyclodextrin, heat to 90°C for clarification, and spray-dry, the air inlet temperature is 220°C, and the outlet air temperature is 90°C. Such beta-cyclodextrin mixed with amoxicillin can increase the solubility of amoxicillin, water-soluble, without floating matter and precipitation.

[0034] 2. Crushing:

[0035] Amoxicillin trihydrate, polyethylene glycol 6000 and beta-cyclodextrin treated in step 1) are respectively pulverized so that the passing rate of No. 2 sieve (24 mesh) is not lower than 99%.

[0036] 3. Mix

[0037] 1) Mix beta-cyclodextrin and PEG6000 in a mixer for 10 minutes to obtain a mixture;

[0038] 2) Add amoxicillin trihydrate equal to the volume of the first mixture and mi...

Embodiment 2

[0113] Embodiment 2 (80% amoxicillin soluble powder preparation)

[0114] Ingredients: Amoxicillin trihydrate 800g, polyethylene glycol 6000 145g, beta cyclodextrin 55g.

[0115] Preparation:

[0116] 1. Beta cyclodextrin pretreatment

[0117] In 500L of water, add 200kg of beta-cyclodextrin, heat to 90°C for clarification, and spray-dry, the air inlet temperature is 220°C, and the outlet air temperature is 90°C. Such beta-cyclodextrin mixed with amoxicillin can increase the solubility of amoxicillin, water-soluble, without floating matter and precipitation.

[0118] 2. Crushing:

[0119] Amoxicillin trihydrate, polyethylene glycol 6000 and beta-cyclodextrin treated in step 1) are respectively pulverized so that the passing rate of No. 2 sieve (24 mesh) is not lower than 99%.

[0120] 3. Mix

[0121] 1) Mix beta-cyclodextrin and PEG6000 in a mixer for 10 minutes to obtain a mixture;

[0122] 2) Add amoxicillin trihydrate equal to the volume of the first mixture and mix i...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses soluble amoxicillin powder and a preparation method thereof. According to the method, amoxicillin serving as a main raw material is mixed with polyethylene glycol 6000 and beta-cyclodextrin subjected to heating dissolution and spray drying pretreatment with an equivalent successively-increasing dilution method, and the neutral soluble amoxicillin powder with the water solubility meeting requirements is obtained. The product is subjected to long-term sample inspection at the temperature of 25 DEG C and the relative humidity of 60% + / -10% for 36 months, and inspection indexes have no remarkable change. Adopted auxiliary materials are simple and easy to obtain, the preparation method is simple, and the product is soluble, good in stability and suitable for industrial production.

Description

technical field [0001] The invention relates to amoxicillin soluble powder and a preparation method thereof, belonging to the technical field of veterinary drug preparations. Background technique [0002] Amoxicillin is the most commonly used penicillin-like broad-spectrum β-lactam antibiotic. Amoxicillin has a strong bactericidal effect and a strong ability to penetrate cell walls. After oral administration of the drug, the lactam group in the molecule is immediately hydrolyzed to form a peptide bond, which quickly combines with the transpeptidase in the bacteria to inactivate it, cutting off the only way for the bacteria to rely on the transpeptidase to synthesize glycopeptides to build the cell wall, so that Bacteria quickly become spheroids and rupture and dissolve, and the bacteria eventually burst and die due to cell wall damage and continuous water penetration. It has a greater bactericidal effect on most pathogenic G+ and G- bacteria (including cocci and bacilli). ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K31/43A61K47/61A61K47/10A61P31/04
CPCA61K9/146A61K31/43
Inventor 工备杨连花
Owner 山东福美乐动物药业有限公司